Now showing items 1-4 of 4

    • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

      Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarrés, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
      Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
    • Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility 

      Fernández, Rosa M. H.; Ruiz Miró, Maria; Dolcet Roca, Xavier; Aldea, Martí; Garí Marsol, Eloi (Nature, 2011)
      Alterations in the levels of adhesion and motility of cells are critical events in the development of metastasis. Cyclin D1 (CycD1) is one of the most frequently amplified oncogenes in many types of cancers and it is ...
    • Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms 

      Pérez Fusté, Noel; Ferrezuelo, Francisco; Garí Marsol, Eloi (Taylor & Francis, 2016-06-27)
      Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. ...
    • Cytoplasmic Cyclin D1 regulates glioblastoma dissemination 

      Cemeli, Tània; Guasch Vallés, Marta; Nàger Grifo, Mireia; Felip, Isidre; Cambray Carner, Serafí; Santacana Espasa, Maria; Gatius Calderó, Sònia; Pedraza González, Neus; Dolcet Roca, Xavier; Ferrezuelo, Francisco; Schuhmacher, Alberto J.; Herreros Danés, Judit; Garí Marsol, Eloi (Wiley, 2019)
      Glioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The CyclinD1 (Ccnd1)/Cdk4-RB1 axis is frequently altered in GBM, leading to over-proliferation by RB1 ...