Now showing items 1-5 of 5

    • A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart 

      Ye, Junmei; Llorian, Miriam; Cardona, Maria; Rongvaux, Anthony; Moubarak, Rana S.; Comella i Carnicé, Joan Xavier; Bassel-Duby, Rhonda; Flavell, Richard A.; Olson, Eric N.; Smith, Christopher W. J.; Sanchis, Daniel (Company of Biologists Ltd., 2013)
      Polypyrimidine tract binding protein (PTB) regulates pre-mRNA splicing, having special relevance for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is ...
    • AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia 

      Yang, Shuai; Zhao, Xinmei; Xu, Hui; Chen, Fan; Xu, Yitao; Li, Zhe; Sanchis, Daniel; Jin, Liang; Zhang, Yubin; Ye, Junmei (MDPI, 2017)
      The AKT (protein kinase B, PKB) family has been shown to participate in diverse cellular processes, including apoptosis. Previous studies demonstrated that protein kinase B2 (AKT2 − / − ) mice heart was sensitized to ...
    • EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes 

      Zhang, Jisheng; Ye, Junmei; Altafaj, Albert; Cardona Colom, Maria; Bahi i Pla, Núria; Llovera i Tomàs, Marta; Cañas, Xavier; Cook, Stuart A.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Public Library of Science (PLoS), 2011)
      Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic ...
    • Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function 

      McDermott Roe, Chris; Ye, Junmei; Ahmed, Rizwan; Sun, Xi-Ming; Serafín, Anna; Ware, James; Bottolo, Leonardo; Muckett, Phil; Cañas, Xavier; Zhang, Jisheng; Rowe, Glenn C.; Buchan, Rachel; Lu, Han; Braithwaite, Adam; Mancini, Massimiliano; Hauton, David; Martí, Ramon; García Arumí, Elena; Hubner, Norbert; Jacob, Howard; Serikawa, Tadao; Zidek, Vaclav; Papousek, Frantisek; Kolar, Frantisek; Cardona Colom, Maria; Ruiz Meana, Marisol; García Dorado, David; Comella i Carnicé, Joan Xavier; Felkin, Leanne E.; Barton, Paul J. R.; Zoltan Arany; Pravenec, Michal; Petretto, Enrico; Sanchis, Daniel; Cook, Stuart A. (Macmillan Publishers Limited, 2011)
      Left ventricular mass (LVM) is a highly heritable trait1 and an independent risk factor for all-cause mortality2. So far, genome-wide association studies have not identified the genetic factors that underlie LVM variation3, ...
    • Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway 

      Ye, Junmei; Cardona, Maria; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Elsevier, 2012)
      The Myocyte Enhancer Factor-2 (MEF2) family of transcription factors regulates gene expression during cardiomyocyte differentiation and adaptation of the myocardium to stress. MEF2 activity is enhanced by increasing its ...