Now showing items 1-5 of 5

    • Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility 

      Fernández, Rosa M. H.; Ruiz Miró, Maria; Dolcet Roca, Xavier; Aldea, Martí; Garí Marsol, Eloi (Nature, 2011)
      Alterations in the levels of adhesion and motility of cells are critical events in the development of metastasis. Cyclin D1 (CycD1) is one of the most frequently amplified oncogenes in many types of cancers and it is ...
    • Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis 

      Moran, Sebastian; Martínez Cardús, Anna; Sayols, Sergi; Musulén, Eva; Balañá, Carme; Estival Gonzalez, Anna; Moutinho, Cátia; Heyn, Holger; Diaz Lagares, Angel; Castro de Moura, Manuel; Stella, Giulia M.; Comoglio, Paolo M.; Ruiz Miró, Maria; Pazo Cid, Roberto; Antón, Antonio; Lopez Lopez, Rafael; Soler, Gemma; Longo, Federico; Guerra, Isabel; Fernandez, Sara; Assenov, Yassen; Plass, Christoph; Morales, Rafael; Carles, Joan; Bowtell, David; Mileshkin, Linda; Sia, Daniela; Tothill, Richard; Tabernero, Josep; Llovet, Josep M.; Esteller, Manel; Matias-Guiu, Xavier (Elsevier, 2016)
      Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary tumour and development of a tailored site-specific therapy could improve the survival ...
    • EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer 

      Roman-Canal, Berta; Tarragona Foradada, Jordi; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; Sierra, José Enrique; Rufas, Maria; González, Esperanza; Porcel Pérez, José Manuel; Gil-Moreno, Antonio; Falcon-Perez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colás, Eva (BioMed Central, 2019)
      Background: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, ...
    • EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer 

      Roman-Canal, Berta; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; González, Esperanza; Ojanguren, Amaia; Recuero, José Luis; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Porcel Pérez, José Manuel; Matias-Guiu, Xavier; Colás, Eva (Nature Research, 2019)
      Lung cancer is the leading cause of cancer-related deaths among men and women in the world, accounting for the 25% of cancer mortality. Early diagnosis is an unmet clinical issue. In this work, we focused to develop a ...
    • Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: discovery and validation studies 

      Hellner, Karin; Miranda, Fabrizio; Fotso Chedom, Donatien; Herrero Gonzalez, Sandra; Hayden, Daniel M.; Tearle, Rick; Artibani, Mara; KaramiNejadRanjbar, Mohammad; Williams, Ruth; Gaitskell, Kezia; Elorbany, Samar; Xu, Ruoyan; Laios, Alex; Buiga, Petronela; Ahmed, Karim; Dhar, Sunanda; Yu Zhang, Rebecca; Campo, Leticia; Myers, Kevin A.; Lozano, María; Ruiz Miró, Maria; Gatius Calderó, Sònia; Mota, Alba; Moreno Bueno, Gema; Matias-Guiu, Xavier; Benítez, Javier; Witty, Lorna; McVean, Gil; Leedham, Simon; Tomlinson, Ian; Drmanac, Radoje; Cazier, Jean Baptiste; Klein, Robert; Dunne, Kevin; Bast Jr, Robert C.; Kennedy, Stephen H.; Hassan, Bassim; Lise, Stefano; Garcia, María José; Peters, Brock A.; Yau, Christopher; Sauka-Spengler, Tatjana; Ashour Ahmed, Ahmed (Elsevier, 2016)
      Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify ...