Browsing Articles publicats (IRBLleida) by Author "Narcís, Oriol J."

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Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA

Narcís, Oriol J.; Tapia, Olga; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Nature Research, 2018)

Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective ...
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus

Tapia, Olga; Narcís, Oriol J.; Riancho, Javier; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Elsevier, 2017)

Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ...