Now showing items 1-20 of 81

    • 2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels 

      Yeramian Hakim, Andree; Veà Jódar, Àlvar; Benítez, Sandra; Ribera i Calvet, Joan; Domingo, Mónica; Santacana Espasa, Maria; Martínez Alonso, Montserrat; Maiques Carlos, Oscar; Valls Marsal, Joan; Dolcet Roca, Xavier; Vilella, Ramón; Cabiscol Català, Elisa; Matias-Guiu, Xavier; Marti, Rosa M. (Wiley online library, 2016)
      Heat shock proteins (HSPs), are molecular chaperones that assist the proper folding of nascent proteins. This study aims to evaluate the antitumour effects of the hsp90 inhibitor NVP-AUY922 in melanoma, both in vitro ...
    • 2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary 

      Losa, F.; Iglesias, L.; Pané, M.; Sanz, J.; Nieto, B.; Fusté, V.; de la Cruz‑Merino, L.; Concha, Á.; Balañá, Carme; Matias-Guiu, Xavier (Springer, 2018)
      Cancer of unknown primary (CUP) is defned as a heterogeneous group of tumours that present with metastasis, and in which attempts to identify the original site have failed. They difer from other primary tumours in their ...
    • A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium 

      Eritja Sánchez, Núria; Felip, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; Navaridas Fernández de Bobadilla, Raúl; Santacana Espasa, Maria; Llobet Navàs, David; Yoshimura, Akihiko; Nomura, Masatoshi; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Publishing Group, 2017-05-19)
      The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ...
    • Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study 

      Visser, Nicole C.M.; van der Putten, Louis J. M.; van Egerschot, Alex; van de Vijver, Koen; Santacana Espasa, Maria; Bronsert, Peter; Hirschfeld, Marc; Colás, Eva; Colás, Eva; Gil-Moreno, Antonio; Garcia, Angel; Mancebo, Gemma; Alameda, Fransesc; Krakstad, Camilla; Tangen, Ingvild L.; Huvila, Jutta; Schrauwen, Stefanie; Koskas, Martin; Walker, Francine; Weinberger, Vit; Minar, Lubos; Hausnerova, Jitka; Snijders, Marc P. L. M.; van den Berg-van Erp, Saskia; Matias-Guiu, Xavier; Trovik, Jone; Amant, Frederic; Massuger, Leon F. A. G.; Bulten, Johan; Pijnenborg, Johanna M. A. (Elsevier, 2019)
      Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding ...
    • An inducible knockout mouse to model the cellautonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias 

      Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Dosil, Maria Alba; Santacana Espasa, Maria; Pallares, Judit; Gatius Calderó, Sònia; Bergadà Bertran, Laura; Maiques Carlos, Oscar; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Company of Biologists, 2013)
      PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple ...
    • Antioxidants impair anti-tumoral effects of Vorinostat, but not anti-neoplastic effects of Vorinostat and caspase-8 downregulation 

      Bergadà Bertran, Laura; Yeramian Hakim, Andree; Sorolla Bardají, Anabel; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Public Library of Science, 2014)
      We have recently demonstrated that histone deacetylase inhibitor, Vorinostat, applied as a single therapy or in combination with caspase-8 downregulation exhibits high anti-tumoral activity on endometrial carcinoma cell ...
    • ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma 

      Megino-Luque, Cristina; Sisó, Pol; Mota Martorell, Natàlia; Navaridas Fernández de Bobadilla, Raúl; de la Rosa, Inés; Urdanibia, Izaskun; Albertí Valls, Manel; Santacana Espasa, Maria; Pinyol, Miquel; Bonifaci, Núria; Macià Armengol, Anna; Llobet Navàs, David; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Eritja Sánchez, Núria (Federation of European Biochemical Societies; John Wiley & Sons, 2022)
      AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ...
    • Autophagy in the physiological endometrium and cancer 

      Devis, Laura; Eritja Sánchez, Núria; Davis, Meredith L.; Matias-Guiu, Xavier; Llobet Navàs, David (Taylor & Francis, 2020-05-13)
      Autophagy is a highly conserved catabolic process and a major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. An increasing body of evidence has unveiled autophagy as an indispensable ...
    • Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer 

      Eritja Sánchez, Núria; Chen, Bo-Juen; Rodríguez Barrueco, Ruth; Santacana Espasa, Maria; Gatius Calderó, Sònia; Vidal, August; Martí, Maria Dolores; Ponce, Jordi; Bergadà Bertran, Laura; Yeramian Hakim, Andree; Encinas Martín, Mario; Ribera i Calvet, Joan; Reventós, Jaume; Boyd, Jeff; Villanueva, Alberto; Matias-Guiu, Xavier; Dolcet Roca, Xavier; Llobet Navàs, David (Taylor & Francis, 2017)
      Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ...
    • Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer 

      Alonso-Alconada, Lorena; de la Fuente, Alexandre; Santacana Espasa, Maria; Ferreiros, Alba; Lopez Lopez, Rafael; Matias-Guiu, Xavier; Abal, Miguel (The Company of Biologists, 2020)
      Metastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for ...
    • BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics 

      Soria, Xavier; Vilardell, Felip; Maiques Carlos, Oscar; Barceló Gómez, Carla; Sisó, Pol; de la Rosa, Inés; Velasco Sánchez, Ana; Cuevas Sánchez, Dolors; Santacana Espasa, Maria; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Rodrigo, Alberto; Macià Armengol, Anna; Martí Laborda, Rosa Ma. (MDPI, 2021)
      Background: Cutaneous melanoma shows high variability regarding clinicopathological presentation, evolution and prognosis. Methods: Next generation sequencing was performed to analyze hotspot mutations in different areas ...
    • BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells 

      Grotsky, David A.; González-Suárez, Ignacio; Novell Álvarez, Anna; Neumann, Martin; Yaddanapudi, Sree C.; Croke, Monica; Martínez Alonso, Montserrat; Redwood, Abena B.; Ortega-Martinez, Sylvia; Feng, Zhihui; Lerma, Enrique; Ramon y Cajal, Teresa; Zhang, Junran; Matias-Guiu, Xavier; Dusso Rosso, Adriana; Gonzalo, Susana (The Rockefeller University Press, 2013)
      Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript ...
    • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

      Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarrés, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
      Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
    • Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma 

      Sanegre, Sabina; Eritja Sánchez, Núria; De Andrea, Carlos; Diaz-Martin, Juan; Diaz-Lagares, Ángel; Jácome, María Amalia; Salguero-Aranda, Carmen; García Ros, David; Davidson, Ben; Lopez, Rafel; Melero, Ignacio; Navarro, Samuel; Ramon y Cajal, Santiago; Alava, Enrique de; Matias-Guiu, Xavier; Noguera, Rosa (Frontiers Media, 2021)
      The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular ...
    • Clinical performance evaluation of the Idylla™ EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cance 

      Delgado-García, Mercedes; Weynand, Birgit; Gómez-Izquierdo, Lourdes; Hernández, María José; Blanco, Ángela María; Varela, Mar; Matias-Guiu, Xavier; Nadal, Ernest; Márquez-Lobo, Bélgica; Alarcão, Ana; de Álava, Enrique; Biscuola, Michele (BMC, 2020)
      Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy ...
    • Clinicopathological and molecular characterisation of "multiple-classifier" endometrial carcinomas 

      León-Castillo, Alicia; Gilvazquez, Ester; Nout, Remi; Smit, Vincent THBM; McAlpine, Jessica N.; McConechy, Melissa; Kommoss, Stefan; Brucker, Sara Y.; Carlson, Joseph W.; Epstein, Elisabeth; Rau, Tilman T.; Soslow, Robert A.; Ganesan, Raji; Matias-Guiu, Xavier; Oliva, Esther; Harrison, Beth T.; Church, David N.; Gilks, C. Blake; Bosse, Tjalling (Wiley, 2019)
      Endometrial carcinoma (EC) molecular classification based on four molecular subclasses identified in The Cancer Genome Atlas (TCGA) has gained relevance in recent years due to its prognostic utility and potential to predict ...
    • Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes 

      Moukarzel, Lea A.; Cruz Paula, Arnaud Da; Ferrando, Lorenzo; Hoang, Timothy; Martins Sebastiao, Ana Paula; Pareja, Fresia; Park, Kay J.; Jungbluth, Achim A; Capellà, Gabriel; Pineda, Marta; Levin, Jeffrey D.; Abu-Rustum, Nadeem R.; Ellenson, Lora H.; Vidal Bel, August; Reis-Filho, Jorge S.; Matias-Guiu, Xavier; Cadoo, Karen; Stadler, Zsofia K.; Weigelt, Britta (Springer Nature; United States and Canadian Academy of Pathology (USCAP), 2021)
      Sporadic synchronous endometrial (ECs) and ovarian cancers (OCs), although clinically considered to be independent primaries, have been shown to be clonally related and likely constitute metastases from each other. We ...
    • Complete Loss of EPCAM Immunoexpression Identifies EPCAM Deletion Carriers in MSH2-Negative Colorectal Neoplasia 

      Cuatrecasas, Miriam; Gorostiaga, Iñigo; Riera, Cristina; Saperas, Esteban; Llort, Gemma; Costa, Irmgard; Matias-Guiu, Xavier; Carrato, Cristina; Navarro, Matilde; Pineda, Marta; Dueñas, Núria; Brunet, Joan; Marco, Vicente; Trias, Isabel; Busteros, José Ignacio; Mateu, Gemma; Balaguer, Francesc; Fernández Figueras, María Teresa; Esteller, Manel; Musulén, Eva (MDPI, 2020)
      The use of epithelial cell adhesion molecule (EPCAM) immunohistochemistry (IHC) is not included in the colorectal cancer (CRC) screening algorithm to detect Lynch syndrome (LS) patients. The aim of the present study was ...
    • Comprehensive constitutional genetic and epigenetic characterization of lynch-like individuals 

      Damaso, Estela; Gonzalez Acosta, Maribel; Vargas Parra, Gardenia; Navarro, Matilde; Balmana, Judith; Ramon y Cajal, Teresa; Tuset, Noemi; Thompson, Bryony A.; Marín, Fàtima; Fernández, Anna; Gómez, Carolina; Velasco, Àngela; Solanes, Ares; Iglesias, Sílvia; Urgel, Gisela; López, Consol; del Valle, Jesús; Campos, Olga; Santacana Espasa, Maria; Matias-Guiu, Xavier; Lázaro, Conxi; Valle, Laura; Brunet, Joan; Pineda, Marta; Capellà, Gabriel (MDPI, 2020)
      The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive ...
    • Concordance study between one-step nucleic acid amplification and morphologic techniques to detect lymph node metastasis in papillary carcinoma of the thyroid 

      del Carmen, Sofía; Gatius Calderó, Sònia; Franch Arcas, Guzmán; Baena-Fustegueras, Juan A; Gonzalez, Oscar; Zafon, Carles; Cuevas Sánchez, Dolors; Valls Marsal, Joan; Pérez, Angustias; Martinez, Mercedes; Ros López, Susana; García Macías, Carmen; Iglesias, Carmela; Matias-Guiu, Xavier; de Álava, Enrique (Elsevier, 2016)
      Tumor resection in papillary thyroid carcinoma (PTC) is often accompanied by lymph node (LN) removal of the central and lateral cervical compartments. One-step nucleic acid amplification (OSNA) is a polymerase chain ...