Now showing items 1-3 of 3

    • Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination 

      De Piccoli, Giacomo; Cortes Ledesma, Felipe; Ira, Gregory; Torres Rosell, Jordi; Uhle, Stefan; Farmer, Sarah; Hwang, Ji-Young; Machín, Félix; Ceschia, Audrey; McAleenan, Alexandra; Cordon Preciado, Violeta; Clemente Blanco, Andrés; Vilella Mitjana, Felipe; Ullal, Pranav; Jarmuz, Adam; Leitao, Beatriz; Bressan, Debra; Dotiwala, Farokh; Papusha, Alma; Zhao, Xiaolan; Myung, Kyungjae; Haber, James E.; Aguilera, Andrés; Aragón, Luis (Nature, 2006)
      DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the ...
    • Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase 

      Machín, Félix; Torres Rosell, Jordi; Jarmuz, Adam; Aragón, Luis (The Rockefeller University Press, 2005)
      Mitotic cell division involves the equal segregation of all chromosomes during anaphase. The presence of ribosomal DNA (rDNA) repeats on the right arm of chromosome XII makes it the longest in the budding yeast genome. ...
    • Transcription of ribosomal genes can cause nondisjunction 

      Machín, Félix; Torres Rosell, Jordi; Piccoli, Giacomo De; Carballo, Jesús A.; Cha, Rita S.; Jarmuz, Adam; Aragón, Luis (The Rockefeller University Press, 2006)
      Mitotic disjunction of the repetitive ribosomal DNA (rDNA) involves specialized segregation mechanisms dependent on the conserved phosphatase Cdc14. The reason behind this requirement is unknown. We show that rDNA ...