Now showing items 1-9 of 9

    • Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation 

      Eritja Sánchez, Núria; Navaridas Fernández de Bobadilla, Raúl; Ruiz Mitjana,Anna; Vidal Sabanés, Maria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (MDPI, 2021-10-05)
      TGF-β has a dichotomous function, acting as tumor suppressor in premalignant cells but as a tumor promoter for cancerous cells. These contradictory functions of TGF-β are caused by different cellular contexts, including ...
    • Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice 

      Cicvaric, Ana; Yang, Jiaye; Bulat, Tanja; Zambon, Alice; Dominguez-Rodriguez, Manuel; Kühn, Rebekka; Sadowicz, Michael G.; Siwert, Anjana; Egea Navarro, Joaquim; Pollak, Daniela D.; Moeslinger, Thomas; Monje, Francisco J. (Nature Publishing Group, 2018)
      The Fibronectin Leucine-Rich Transmembrane protein 2 (FLRT2) has been implicated in several hormone -and sex-dependent physiological and pathological processes (including chondrogenesis, menarche and breast cancer); is ...
    • FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons 

      Yamagishi, Satoru; Hampel, Falko; Hata, Katsuhiko; Toro, Daniel del; Schwark, Manuela; Kvachnina, Elena; Bastmeyer, Martin; Yamashita, Toshihide; Tarabykin, Victor; Klein, Rüdiger; Egea Navarro, Joaquim (EMBO Press, 2011)
      Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of ...
    • FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons 

      Leyva-Díaz, Eduardo; Toro, Daniel del; Menal Castellote, Maria José; Cambray Carner, Serafí; Susín, Rafael; Tessier-Lavigne, Marc; Klein, Rüdiger; Egea Navarro, Joaquim; López-Bendito, Guillermina (Elsevier, 2014)
      Background: Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical ...
    • Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development 

      Akita, Tenpei; Kumada, Tatsuro; Yoshihara, Sei-ichi; Egea Navarro, Joaquim; Yamagishi, Satoru (Springer, 2015)
      Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and ...
    • Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency 

      Fico, Annalisa; Chevigny, Antoine De; Egea Navarro, Joaquim; Bösl, Michael R.; Cremer, Harold; Maina, Flavio; Dono, Rosanna (Wiley, 2012)
      Self-renewal and differentiation of stem cell depend on a dynamic interplay of cell-extrinsic and -intrinsic regulators. However, how stem cells perceive the right amount of signal and at the right time to undergo a ...
    • Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA 

      Javier-Torrent, Míriam; Marco, Sergio; Rocandio, Daniel; Pons-Vizcarra, Maria; Janes, Peter W; Lackmann, Martin; Egea Navarro, Joaquim; Saura, Carlos A (eLife Sciences Publications, 2019)
      EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the ...
    • proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing 

      Fleitas Pérez, Catherine; Piñol Ripoll, Gerard; Marfull Oromí, Pau; Rocandio, Daniel; Ferrer, Isidre; Rampon, Claire; Egea Navarro, Joaquim; Espinet Mestre, Carme (BMC, 2018)
      Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential for the survival and differentiation of ...
    • Sprouty1 controls genitourinary development via its N-terminal tyrosine 

      Vaquero, Marta; Cuesta, Sara; Anerillas, Carlos; Altés, Gisela; Ribera i Calvet, Joan; Basson, M. Albert; Licht, Jonathan D.; Egea Navarro, Joaquim; Encinas Martín, Mario (American Society of Nephrology, 2019-08-01)
      Background: Congenital anomalies of the kidney and urinary tract (CAKUT) is a group of diseases that include a broad spectrum of developmental defects of the genitourinary system. Mouse models indicate that perturbations ...