Now showing items 99-118 of 906

    • Benign and malignant nodular thyroid disease in acromegaly. Is a routine thyroid ultrasound evaluation advisable? 

      Reverter, Jordi L.; Fajardo, Carmen; Resmini, Eugenia; Salinas, Isabel; Mora, Mireia; Llatjós, Mariona; Sesmilo, Gemma; Rius, Ferran; Halperin, Irene; Webb, Susan M.; Ricart, Veronica; Riesgo, Pedro; Mauricio Puente, Dídac; Puig-Domingo, Manuel (Public Library of Science (PLoS), 2014)
      Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this ...
    • Bevacizumab plus preoperative chemotherapy in operable HER2 negative breast cancer: biomarkers and pathologic response 

      Sánchez Rovira, Pedro; Seguí, M. A.; Llombart, A.; Aranda, Enrique; Antón, Antonio; Sánchez, A.; Lomas, M.; Jaén, A.; Fernández, M.; Porras, I.; Dalmau, E.; Morales Murillo, Serafín; Haba-Rodríguez, J. de la (Springer, 2013)
      Purpose: The primary aim of this trial was to assess the rate of pathologic complete responses (pCR) of doxorubicin/cyclophosphamide (AC) followed by bevacizumab/docetaxel (BT), as neoadjuvant therapy for breast cancer ...
    • Biblio-MetReS for user-friendly mining of genes and biological processes in scientific documents 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Alves, Rui; Solsona Tehàs, Francesc (PeerJ, 2014)
      One way to initiate the reconstruction of molecular circuits is by using automated text-mining techniques. Developing more efficient methods for such reconstruction is a topic of active research, and those methods are ...
    • Biblio-MetReS: A bibliometric network reconstruction application and server 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Valls Marsal, Joan; Faus i Torà, Xavier; Alves, Rui; Solsona Tehàs, Francesc (BioMed Central, 2011)
      Background: Reconstruction of genes and/or protein networks from automated analysis of the literature is one of the current targets of text mining in biomedical research. Some user-friendly tools already perform this ...
    • Bin-CE: A comprehensive web application to decide upon the best set of outcomes to be combined in a binary composite endpoint 

      Marsal Mora, Josep Ramon; Ferreira-González, Ignacio; Ribera, Aida; Oristrell, Gerard; Pijoan, Jose Ignacio; García-Dorado, David (Public Library of Science, 2018)
      The estimation of the Sample Size Requirement (SSR) when using a binary composite endpoint (i.e. two or more outcomes combined in a unique primary endpoint) is not trivial. Besides information about the rate of events for ...
    • Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin 

      Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2003)
      Grx5 is a yeast mitochondrial protein involved in iron- sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins. No member of this family has been biochemically charac- terized ...
    • Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness 

      Ruiz‑Plazas, Xavier; Rodríguez‑Gallego, Esther; Alves, Marta; Altuna Coy, Antonio; Lozano‑Bartolomé, Javier; Portero Otín, Manuel; García‑Fontgivell, Joan Francesc; Martínez‑González, Salomé; Segarra, José; Chacón, Matilde R. (BMC (part of Springer Nature), 2019)
      Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ...
    • Biofortification of crops with nutrients: factors affecting utilization and storage 

      Díaz Gómez, Joana; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
      Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
    • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

      Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
      X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
    • Biomarkers of aging in Drosophila 

      Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
      Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae 

      Matias, Ana C.; Marinho, H. Susana; Cyrne, Luísa; Herrero Perpiñán, Enrique; Antunes, Fernando (Elsevier, 2011)
      Taking into account published contradictory results concerning the regulation of fatty acid synthase (Fas) by H2O2, we carried out a systematic study where two methods of H2O2 delivery (steady-state and bolus addition) ...
    • Biweekly cetuximab in combination with FOLFOX-4 in the first-line treatment of wild-type KRAS metastatic colorectal cancer: final results of a phase II, open-label, clinical trial (OPTIMIX-ACROSS Study) 

      Fernandez-Plana, Julen; Pericay, Carles; Quintero, Guillermo; Alonso, Vicente; Salud Salvia, Maria Antonieta; Mendez, Miguel; Salgado, Mercedes; Saigi, Eugeni; Cirera, Luis (BMC, 2014)
      Background: This phase II study aims to evaluate the efficacy and safety of biweekly cetuximab in combination with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) as first-line treatment of metastatic wild-type KRAS ...
    • Brain structural correlates of emotion recognition in psychopaths 

      Pera Guardiola, Vanessa; Contreras-Rodríguez, Oren; Batalla, Iolanda; Kosson, David; Menchón, José M.; Pifarré Paredero, Josep; Bosque, Javier; Cardoner, N. (Narcís); Soriano-Mas, Carles (Public Library of Science, 2016)
      Individuals with psychopathy present deficits in the recognition of facial emotional expressions. However, the nature and extent of these alterations are not fully understood. Furthermore, available data on the functional ...
    • BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells 

      Grotsky, David A.; González-Suárez, Ignacio; Novell Álvarez, Anna; Neumann, Martin; Yaddanapudi, Sree C.; Croke, Monica; Martínez Alonso, Montserrat; Redwood, Abena B.; Ortega-Martinez, Sylvia; Feng, Zhihui; Lerma, Enrique; Ramon y Cajal, Teresa; Zhang, Junran; Matias-Guiu, Xavier; Dusso Rosso, Adriana; Gonzalo, Susana (The Rockefeller University Press, 2013)
      Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript ...
    • Breakdown in the brain network subserving moral judgment in criminal psychopathy 

      Pujol Salud, Jesús; Batalla, Iolanda; Contreras-Rodríguez, Oren; Harrison, Ben J.; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Real, Eva; Bosa, Laura; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Oxford University Press, 2012)
      Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in normal population, and has suggested the inappropriate network use in criminal psychopathy. We ...
    • Breast cancer incidence and overdiagnosis in Catalonia (Spain) 

      Martínez Alonso, Montserrat; Vilaprinyo Terré, Ester; Marcos-Gragera, Rafael; Rué i Monné, Montserrat (BioMed Central, 2010)
      Introduction: Early detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to ...
    • Brote de gastroenteritis por el consumo de agua de suministro público causado por Shigella sonnei 

      Godoy i García, Pere; Bartolomé, Rosa; Torres Puig-gros, Joan; Espinet, Lina; Escobar, Amàlia; Nuin Orrio, Carmen; Domínguez, Ángela (Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS)Elsevier, 2011)
      Objetivos: Investigar un brote de gastroenteritis que afectó a la población de València d’Àneu (Lleida). Métodos: Estudio de cohortes sobre el consumo de agua de la red, de agua embotellada y de agua de manantiales. La ...
    • Budget impact analysis of switching to digital mammography in a population-based breast cancer screening program: a discrete event simulation model 

      Comas, Mercè; Arrospide, Arantzazu; Mar, Javier; Sala i Serra, Maria; Vilaprinyo Terré, Ester; Hernández, Cristina; Cots, Francesc; Martínez, Juan; Castells, Xavier (Public Library of Science, 2014)
      Objective: To assess the budgetary impact of switching from screen-film mammography to full-field digital mammography in a population-based breast cancer screening program. Methods: A discrete-event simulation model was ...
    • Burnout and job satisfaction among nurses in three Spanish regions 

      Acea-López, Lorena; Pastor-Bravo, María del Mar; Rubinat, Esther; Bellon, Filip; Blanco Blanco, Joan; Gea Sánchez, Montserrat; Briones Vozmediano, Erica Tula (Wiley, 2021-05-15)
      Aims: To determine the levels of job satisfaction and burnout syndrome and related factors among nurses in three Spanish regions. Background: The nursing profession involves high work stress due to emotional involvement, ...