Now showing items 911-930 of 960

    • Transcriptomic responses of Phanerochaete chrysosporium to oak acetonic extracts: focus on a new glutathione transferase. 

      Thuillier, Anne; Chibani, Kamel; Bellí i Martínez, Gemma; Herrero Perpiñán, Enrique; Dumarçay, Stéphane; Gérardin, Philippe; Kohler, Annegret; Deroy, Aurélie; Dhalleine, Tiphaine; Bchini, Raphael; Jacquot, Jean Pierre; Gelhaye, Eric; Morel-Rouhier, Mélanie (American Society for Microbiology, 2014)
      The first steps of wood degradation by fungi lead to the release of toxic compounds known as extractives. To better understand how lignolytic fungi cope with the toxicity of these molecules, a transcriptomic analysis of ...
    • Transdermal rotigotine improves sleep fragmentation in parkinson’s disease: results of the multicenter, prospective SLEEP-FRAM study 

      Pagonabarraga, Javier; Piñol Ripoll, Gerard; Cardozo, Adriana; Sanz, Pilar; Puente, Víctor; Otermín, Pilar; Legarda, Inés; Delgado, Tania; Serrano, Carmen; Balaguer, Ernest; Aguirregomozcorta, María; Álvarez, Ramiro; Kulisevsky, Jaime J. (Hindawi Publishing Corporation, 2015)
      Sleep disturbances occur frequently in patients with Parkinson’s disease (PD). The aim of this study was to investigate the effects of rotigotine on sleep fluctuations in a sample of PD patients with self-reported complaints ...
    • Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway 

      Ye, Junmei; Cardona, Maria; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Elsevier, 2012)
      The Myocyte Enhancer Factor-2 (MEF2) family of transcription factors regulates gene expression during cardiomyocyte differentiation and adaptation of the myocardium to stress. MEF2 activity is enhanced by increasing its ...
    • Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers 

      Izquierdo, Cristina; Zarama Ortiz, Angela; Presa, Maximiliano; Malo, Sara; Montoya, Anna; Garabatos, Nahir; Mora Giral, Concepció; Verdaguer Autonell, Joan; Stratmann, Thomas (Nature Publishing Group, 2018)
      Type 1 diabetes can be overcome by regulatory T cells (Treg) in NOD mice yet an efficient method to generate and maintain antigen-specific Treg is difficult to come by. Here, we devised a combination therapy of peptide/MHC ...
    • Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality 

      Casas-Méndez, Luis Fernando; Abadías, María José; Yuguero Torres, Oriol; Bardés Robles, Ignasi; Barbé Illa, Ferran; Batlle Garcia, Jordi de (Public Library of Science, 2018)
      Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless ...
    • Trends and patterns in the use of computed tomography in children and young adults in Catalonia — results from the EPI-CT study 

      Bosch de Basea, Magda; Salotti, Jane A.; Pearce, Mark S.; Muchart, Jordi; Riera, Luis; Barber, Ignasi; Pedraza, Salvador; Pardina Solano, Marina Asunción; Capdevila, Antoni; Espinosa, Ana; Cardis, Elisabeth (Springer, 2016)
      Background Although there are undeniable diagnostic benefits of CT scanning, its increasing use in paediatric radiology has become a topic of concern regarding patient radioprotection. Objective To assess the rate of CT ...
    • Trends in detection of invasive cancer and ductal carcinoma in situ at biennial screening mammography in Spain: a retrospective cohort study 

      Román Expósito, Marta; Rué i Monné, Montserrat; Ascunce, Nieves; Baré, Marisa; Baroja, Araceli; Vega, Mariola de la; Galcerán, Jaume; Natal, Carmen; Salas, Dolores; Sánchez-Jacob, Mercedes; Zubizarreta, Raquel; Castells, Xavier (Public Library of Science, 2013)
      Background: Breast cancer incidence has decreased in the last decade, while the incidence of ductal carcinoma in situ (DCIS) has increased substantially in the western world. The phenomenon has been attributed to the ...
    • Trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs in the health region of Lleida from 2002 to 2015 

      Torres Bondia, Francisco Ignacio; Batlle Garcia, Jordi de; Galván, Leonardo; Buti, Miquel; Barbé Illa, Ferran; Piñol Ripoll, Gerard (Biomed Central, 2020-06-01)
      Background: The high prevalence and long-term use of benzodiazepines (BZDs) treatment are debated topics because of the risk they can cause to the patients. Despite the current information on the risk-benefit balance of ...
    • Tumor phenotype and breast density in distinct categories of interval cancer: results of population-based mammography screening in Spain 

      Domingo, Laia; Salas, Dolores; Zubizarreta, Raquel; Baré, Marisa; Sarriugarte, Garbiñe; Barata, Teresa; Ibáñez, Josefa; Blanch, Jordi; Puig-Vives, Montserrat; Fernández, Ana Belén; Castells, Xavier; Sala i Serra, Maria; Interval Cancer Study Group (BioMed Central, 2014)
      Introduction: Interval cancers are tumors arising after a negative screening episode and before the next screening invitation. They can be classified into true interval cancers, false-negatives, minimal-sign cancers, and ...
    • Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients 

      Eritja Sánchez, Núria; Jové Font, Mariona; Eldevik Fasmer, Kristine; Gatius Calderó, Sònia; Portero Otín, Manuel; Trovik, Jone; Krakstad, Camilla; Sol, Joaquim; Pamplona Gras, Reinald; Haldorsen, Ingfrid S.; Matias-Guiu, Xavier (Impact Journals, 2017)
      Purpose: We aimed to study the potential influence of tumour blood flow –obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours. Methods: Liquid ...
    • Two component systems: physiological effect of a third component 

      Salvadó López, Baldiri; Vilaprinyo Terré, Ester; Karathia, Hiren; Sorribas Tello, Albert; Alves, Rui (Public Library of Science, 2012)
      Signal transduction systems mediate the response and adaptation of organisms to environmental changes. In prokaryotes, this signal transduction is often done through Two Component Systems (TCS). These TCS are phosphotransfer ...
    • Type 1 diabetic subjects with diabetic retinopathy show an unfavorable pattern of fat intake 

      Granado Casas, Minerva; Ramírez-Morros, Anna; Martín, Mariona; Real, Jordi; Alonso, Núria; Valldeperas, Xavier; Traveset Maeso, Alicia; Rubinat, Esther; Alcubierre Calvo, Núria; Hernández García, Marta; Puig-Domingo, Manuel; Lecube Torelló, Albert; Castelblanco Echavarría, Esmeralda; Mauricio Puente, Dídac (MDPI, 2018-08-29)
      Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetes management and its diabetic complications. Our ...
    • Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy 

      Alonso, Núria; Traveset Maeso, Alicia; Rubinat, Esther; Ortega, Emilio; Alcubierre Calvo, Núria; Sanahuja Montesinos, Jordi; Hernández García, Marta; Betriu i Bars, M. Àngels; Jurjo Campo, Carmen; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (BioMed Central, 2015)
      Background: Cardiovascular disease (CVD) is the leading cause of mortality among subjects with type 2 diabetes (T2D), and diabetic retinopathy (DR) has been associated with an increased risk for CVD. The present study was ...
    • Type-Dependent Oxidative Damage Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage 

      Martínez, Anna; Carmona, Margarita; Portero Otín, Manuel; Naudí i Farré, Alba; Pamplona Gras, Reinald; Ferrer, Isidre (Oxford University Press, 2008)
      Oxidative injury and stress responses are common features of many neurodegenerative diseases. To assess oxidative stress responses in frontotemporal lobar degeneration (FTLD), we identified increased 4-hydroxynonenal ...
    • Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling 

      Georgieva, Maya V.; Pablo Llavall, Yolanda de; Sanchis, Daniel; Comella i Carnicé, Joan Xavier; Llovera i Tomàs, Marta (Wiley, 2011)
      The nerve growth factor receptor TrkA (tropomyosin-related kinase receptor) participates in the survival and differentiation of several neuronal populations. The C-terminal tail of TrkA contains a PPXY motif, the binding ...
    • Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes 

      Castelblanco Echavarría, Esmeralda; Betriu i Bars, M. Àngels; Hernández García, Marta; Granado Casas, Minerva; Ortega, Emilio; Soldevila, Berta; Ramírez-Morros, Anna; Franch-Nadal, Josep; Puig-Domingo, Manuel; Fernández i Giráldez, Elvira; Avogaro, Angelo; Alonso, Núria; Mauricio Puente, Dídac (MDPI, 2019-03-28)
      The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of ...
    • Unilateral milia-type intradermal tophi associated with underlying urate subcutaneous deposition: an uncommon cutaneous presentation of gout 

      Aguayo Ortiz, Rafael; Baradad Brusau, Manuel; Soria, Xavier; Abal Diaz, Leandro; Sanmartín Novell, Verònica; Egido Garcia, Ramon Maria; Gallel Vicente, María del Pilar; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (Wiley online library, 2013)
      Tophi develop during the most advanced clinical stage of gout, and are usually located on or around the joints. However, unusual skin features caused by intradermal and/or subcutaneous deposition of tophaceous material ...
    • Univariate Parametric Survival Analysis using GS-distributions 

      Sorribas Tello, Albert; Muiño, José M.; Rué i Monné, Montserrat; Fibla Palazón, Joan (Institut d'Estadística de Catalunya (Idescat), 2006)
      The GS-distribution is a family of distributions that provide an accurate representation of any unimodal univariate continuous distribution. In this contribution we explore the utility of this family as a general model in ...
    • Up-Regulation of Specific Bioactive Lipids in Celiac Disease 

      Martín Masot, Rafael; Galo-Licona, José Daniel; Mota Martorell, Natàlia; Sol, Joaquim; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2021)
      Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome of CD subjects have been documented. ...
    • Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19 

      Buxeda, Anna; Arias Cabrales, Carlos; Pérez Sáez, María José; Cacho, Judit; Cabello Pelegrin, Sheila; Melilli, Edoardo; Aladrén, María José; Galeano, Cristina; Lorenzo, Inmaculada; Mazuecos, Auxiliadora; Saura, Isabel María; Franco, Antonio; Ruiz Fuentes, María del Carmen; Sánchez Cámara, Luis Alberto; Siverio, Orlando; Martín Conde, María Luisa; González García, Elena; López, Verónica; Martin Moreno, Paloma Leticia; Moina, Iñigo; Moral Berrio, Esperanza; Moreso, Francesc; Portolés, José María; Santana Estupiñán, Raquel; Zárraga, Sofía; Canal, Cristina; Sánchez Álvarez, Emilio; Pascual, Julio; Crespo, Marta (Elsevier, 2021)
      Introduction:Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time torecovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acutekidney injury have ...