Now showing items 79-98 of 910

    • Association of BST-2 Gene Variants With HIV Disease Progression Underscores the Role of BST-2 in HIV Type 1 Infection 

      Laplana Lafaja, Marina; Caruz, Antonio; Pineda, Juan Antonio; Puig, Teresa; Fibla Palazón, Joan (Oxford University Press, 2013-02-01)
      We tested bone marrow stromal cell antigen 2 (BST-2) gene variants rs3217318, a 19-base-pair insertion/deletion polymorphism in the promoter region, and rs10415893, a tag single-nucleotide polymorphism in the 3′ untranslated ...
    • Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort 

      Valls, Joan; Cambray Carner, Serafí; Pérez-Guallar, Carles; Bozić Stanojević, Milica; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Betriu i Bars, M. Àngels; Rodríguez, Isabel; Valdivielso Revilla, José Manuel (Frontiers Media, 2019)
      Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, ...
    • Association of complement receptor 2 polymorphisms withinnate resistance to HIV-1 infection 

      Herrero, Rocío; Real, Luis M.; Rivero-Juárez, Antonio; Pineda, Juan Antonio; Camacho, Ángela; Macías, Juan; Laplana Lafaja, Marina; Konieczny, Piotr; Márquez, Francisco J.; Souto, Juan Carlos; Soria, José Manuel; Saulle, Irma; Lo Caputo, Sergio; Biasin, Mara; Rivero, Antonio; Fibla Palazón, Joan; Caruz, Antonio (Springer Nature, 2015-03)
      HIV-1 induces activation of complement through the classical and lectin pathways. However, the virus incorporates several membrane-bound or soluble regulators of complement activation (RCA) that inactivate complement. HIV-1 ...
    • Association of FGF-2 Concentrations with Atheroma Progression in Chronic Kidney Disease Patients 

      Bozić Stanojević, Milica; Betriu i Bars, M. Àngels; Bermúdez López, Marcelino; Ortiz, Alberto; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (American Society of Nephrology, 2018)
      Background and objectives: Atherosclerosis is highly prevalent in CKD. The rate of progression of atherosclerosis is associated with cardiovascular events. Fibroblast growth factor 2 (FGF-2) is a member of the FGF family ...
    • Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study 

      Alcubierre Calvo, Núria; Navarrete Muñoz, Eva María; Rubinat, Esther; Falguera, Mireia; Valls Marsal, Joan; Traveset Maeso, Alicia; Vilanova, María-Belén; Marsal Mora, Josep Ramon; Hernández, Marta; Granado Casas, Minerva; Martínez González, María Dolores; Jurjo Campo, Carmen; Franch-Nadal, Josep; Vioque, Jesus; Mauricio Puente, Dídac (BioMed Central, 2016)
      Background: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. Methods: ...
    • Association of serum phosphorus with subclinical atherosclerosis in chronic kidney disease. Sex makes a difference 

      Martín, Marisa; Valls Marsal, Joan; Betriu i Bars, M. Àngels; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Elsevier, 2015-02-28)
      Abstract BACKGROUND: Cardiovascular disease is the leading cause of mortality in chronic kidney disease (CKD). Serum phosphate has been associated to cardiovascular disease in the general population and this effect seems ...
    • ATPase-dependent control of the Mms21 SUMO ligase during DNA repair 

      Bermúdez López, Marcelino; Pociño Merino, Irene; Sánchez, Humberto; Bueno, Andrés; Guasch, Clàudia; Almedawar, Seba; Brú i Virgili, Sergi; Garí Marsol, Eloi; Wyman, Claire; Reverter Cendrós, David; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Plos Biology, 2015-03-12)
      Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus ...
    • Auditing the management of vaccine-preventable disease outbreaks: the need for a tool 

      Torner Gràcia, Núria; Carnicer-Pont, Dolors; Castilla, Jesús; Cayla, Joan; Godoy i García, Pere; Domínguez García, Àngela; Epidemiological Surveillance Working Group of Catalonia and Navarre (Public Library of Science, 2011)
      Public health activities, especially infectious disease control, depend on effective teamwork. We present the results of a pilot audit questionnaire aimed at assessing the quality of public health services in the management ...
    • Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation 

      Mattiolo, Paolo; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2015-12)
      Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and ...
    • Autophagy in the physiological endometrium and cancer 

      Devis, Laura; Eritja Sánchez, Núria; Davis, Meredith L.; Matias-Guiu, Xavier; Llobet Navàs, David (Taylor & Francis, 2020-05-13)
      Autophagy is a highly conserved catabolic process and a major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. An increasing body of evidence has unveiled autophagy as an indispensable ...
    • Autophagy modulators regulate survival motor neuron protein stability in motoneurons 

      Periyakaruppiah, Ambika; Fuente Ruiz, Sandra de la; Arumugam, Saravanan; Bahi i Pla, Núria; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2016)
      SpinalMuscular Atrophy (SMA), a neurodegenerative disorder primarily affecting motoneurons (MNs), is caused by the loss of the Survival Motor Neuron 1 (SMN1) gene and reduced levels of full-length survival motor neuron (SMN) ...
    • Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer 

      Eritja Sánchez, Núria; Chen, Bo-Juen; Rodríguez Barrueco, Ruth; Santacana Espasa, Maria; Gatius Calderó, Sònia; Vidal, August; Martí, Maria Dolores; Ponce, Jordi; Bergadà Bertran, Laura; Yeramian Hakim, Andree; Encinas Martín, Mario; Ribera i Calvet, Joan; Reventós, Jaume; Boyd, Jeff; Villanueva, Alberto; Matias-Guiu, Xavier; Dolcet Roca, Xavier; Llobet Navàs, David (Taylor & Francis, 2017)
      Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ...
    • B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse 

      Carrascal, Jorge; Carrillo, Jorge; Arpa i Puigdemont, Berta; Egia-Mendikute, Leire; Rosell Mases, Estela; Pujol Autonell, Irma; Planas, Raquel; Mora Giral, Concepció; Mauricio Puente, Dídac; Ampudia, Rosa Maria; Vives Pi, Marta; Verdaguer Autonell, Joan (Wiley online library, 2016)
      Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the ...
    • B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes 

      Egia-Mendikute, Leire; Arpa i Puigdemont, Berta; Rosell Mases, Estela; Corral-Pujol, Marta; Carrascal, Jorge; Carrillo, Jorge; Mora Giral, Concepció; Chapman, Harold; Panosa, Anaïs; Vives Pi, Marta; Stratmann, Thomas; Serreze, David; Verdaguer Autonell, Joan (Frontiers Media, 2019)
      Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ...
    • B-Type Natriuretic Peptides Help in Cardioembolic Stroke Diagnosis: Pooled Data Meta-Analysis. 

      Llombart Sebastià, Víctor; Antolin-Fontes, Albert; Bustamante Rangel, Alejandro; Giralt Casellas, Dolors; Rost, Natalia S.; Furie, Karen; Shibazaki, Kensaku; Biteker, Murat; Castillo, José; Rodríguez-Yáñez, Manuel; Fonseca, Ana Caterina; Watanabe, Tetsu; Purroy Garcia, Francisco; Zhixin, Wu; Etgen, Thorleif; Hosomi, Naohisa; Kerman, Scott Reza Jafarian; Sharma, Jagdish C.; Knauer, Carolin; Santamarina Pérez, Estevo; Giannakoulas, George; García Berrocoso, Teresa; Montaner Villalonga, Joan (American Heart Association, 2015-03-12)
      Background and Purpose. Determining the underlying cause of stroke is important to optimize secondary prevention treatment. Increased blood levels of natriuretic peptides (B-type natriuretic peptide/N-terminal pro-BNP ...
    • Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells 

      Varano della Vergiliana, Julius F.; Lansley, Sally M.; Porcel Pérez, José Manuel; Bielsa Martín, Silvia; Brown, Jeremy S.; Creaney, Jenette; Temple, Suzanna E. L.; Waterer, Grant W.; Gary Lee, Y. C. (Public Library of Science, 2013)
      Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response ...
    • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

      Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
      β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
    • BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis 

      Garrofé Ochoa, Xènia; Melero Fernández de Mera, Raquel M; Fernández Gómez, Francisco J.; Ribas i Fortuny, Judit; Jordán Bueso, Joaquín; Boix Torras, Jacint (American Association for Cancer Research, 2008)
      In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ...
    • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

      Armero, Carmen; Forné Izquierdo, Carles; Rué i Monné, Montserrat; Forte, Anabel; Perpiñán, Hèctor; Gómez, Guadalupe; Baré, Marisa (Wiley, 2016)
      We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...
    • Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast 

      Ferrezuelo, Francisco; Aldea, Martí; Futcher, Bruce (Landes Bioscience, 2009)
      During the cell division cycle of the yeast Saccharomyces cerevisiae, the G1-to-S transition depends upon the activation of two transcription factors (SBF and MBF), which are responsible for the cell cycle-regulated ...