Now showing items 740-759 of 906

    • Sit4 is required for proper modulation of the biological functions mediated by Pkc1 and the cell integrity pathway in Saccharomyces cerevisiae 

      Torre Ruiz, M. A. de la; Torres Rosell, Jordi; Ariño Carmona, Joaquín; Herrero Perpiñán, Enrique (The American Society for Biochemistry and Molecular Biology, 2002)
      Maintenance of cellular integrity in Saccharomyces cerevisiae is carried out by the activation of the protein kinase C-mediated mitogen-activated protein kinase (PKC1-MAPK) pathway. Here we report that correct down-regulation ...
    • Situación de la investigación en el cribado de cáncer de mama en España: implicaciones para la prevención 

      Sala i Serra, Maria; Salas, Dolores; Zubizarreta, Raquel; Ascunce, Nieves; Rué i Monné, Montserrat; Castells, Xavier (Elsevier, 2012)
      Objetivo: La finalización del despliegue de los programas de detección precoz de cáncer de mama en todas las comunidades autónomas de España ha facilitado el inicio de una investigación conjunta, con información procedente ...
    • SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L 

      Coccia, Elena; Planells Ferrer, Laura; Badillos-Rodríguez, Raquel; Pascual, Marta; Segura Ginard, Miguel Francisco; Fernández-Hernández, Rita; López-Soriano, Joaquín; Garí Marsol, Eloi; Soriano, Eduardo; Barneda-Zahonero, Bruna; Moubarak, Rana S.; Pérez-García, M. Jose; Comella i Carnicé, Joan Xavier (Springer Nature, 2020)
      The long isoform of Fas apoptosis inhibitory molecule (FAIM-L) is a neuron-specific death receptor antagonist that modulates apoptotic cell death and mechanisms of neuronal plasticity. FAIM-L exerts its antiapoptotic action ...
    • Sixty years old is the breakpoint of human frontal cortex aging 

      Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natàlia; Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
      Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...
    • Síndrome de Ross: una causa infrecuente neurológica de trastorno de la sudoración 

      Balcells Terés, Anna; Sanahuja Montesinos, Jordi; Guitard Sein-Echaluce, Ma. Luisa; Albertí, Antonia; Ortiz, Ariadna; Barcenilla Gaite, Fernando (Viguera Editores, 2014-10-01)
      El síndrome de Ross es una rara entidad de disfunción degenerativa del sistema nervioso autónomo, que se caracteriza por la tríada de pupila tónica de Adie, arreflexia osteotendinosa y hipohidrosis/anhidrosis segmentaria. ...
    • Skin autofluorescence and subclinical atherosclerosis in mild to moderate chronic kidney disease: a case-control study 

      Sánchez Peña, Enric; Betriu i Bars, M. Àngels; Arroyo, David; López Cano, Carolina; Hernández, Marta; Rius, Ferran; Fernández i Giráldez, Elvira; Lecube Torelló, Albert (Public Library of Science, 2017)
      Advanced glycation end-products (AGEs) are increased and predict mortality in patients with chronic kidney disease (CKD) who are undergoing hemodialysis, irrespective of the presence of type 2 diabetes. However, little ...
    • Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project 

      Sánchez Peña, Enric; Betriu i Bars, M. Àngels; Yeramian Hakim, Andree; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Sánchez de la Torre, Manuel; Pamplona Gras, Reinald; Miquel, Eva; Kerkeni, M.; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (Japan Atherosclerosis Society, 2019)
      AIM: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in ...
    • Sleep Apnea and Hypertension: Are there gender differences? The Vitoria Sleep Cohort 

      Cano-Pumarega, Irene; Barbé Illa, Ferran; Esteban, Andrés; Martínez Alonso, Montserrat; Egea, Carlos; Durán-Cantolla, Joaquín; Spanish Sleep Network (American College of Chest Physicians, 2017-03-11)
      Background Evidence from longitudinal studies has reported contradictory results regarding the association between obstructive sleep apnea (OSA) and hypertension. In a previous analysis of the Vitoria Sleep Cohort, we ...
    • Small-Molecule Inhibitors (SMIs) as an Effective Therapeutic Strategy for Endometrial Cancer 

      Megino-Luque, Cristina; Moiola, Cristian P.; Molins-Escuder, Clara; López-Gil, Carlos; Gil-Moreno, Antonio; Matias-Guiu, Xavier; Colás, Eva; Eritja Sánchez, Núria (MDPI, 2020-09-24)
      Endometrial cancer (EC) is the sixth most common cancer in women. A continued number of low-risk EC patients at diagnosis, as well as patients diagnosed with advanced-stage disease, will experience an aggressive disease. ...
    • Smc5/6, an atypical SMC complex with two RING-type subunits 

      Solé-Soler, Roger; Torres Rosell, Jordi (Portland Press, 2020-10-30)
      Smc5/6, an atypical SMC complex with two RING-type subunits Roger Solé-Soler ; Jordi Torres-Rosell Crossmark: Check for Updates Biochem Soc Trans (2020) 48 (5): 2159-2171. https://doi.org/10.1042/BST20200389 Article history ...
    • Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination 

      De Piccoli, Giacomo; Cortes Ledesma, Felipe; Ira, Gregory; Torres Rosell, Jordi; Uhle, Stefan; Farmer, Sarah; Hwang, Ji-Young; Machín, Félix; Ceschia, Audrey; McAleenan, Alexandra; Cordon Preciado, Violeta; Clemente Blanco, Andrés; Vilella Mitjana, Felipe; Ullal, Pranav; Jarmuz, Adam; Leitao, Beatriz; Bressan, Debra; Dotiwala, Farokh; Papusha, Alma; Zhao, Xiaolan; Myung, Kyungjae; Haber, James E.; Aguilera, Andrés; Aragón, Luis (Nature, 2006)
      DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the ...
    • Smn-deficiency increases the intrinsic excitability of motoneurons 

      Arumugam, Saravanan; Garcera, Ana; Soler i Tatché, Rosa Ma.; Tabares, Lucía (Frontiers Media, 2017)
      During development, motoneurons experience significant changes in their size and in the number and strength of connections that they receive, which requires adaptive changes in their passive and active electrical properties. ...
    • Social environment mediates cancer progression in Drosophila 

      Dawson, Erika H.; Bailly, Tiphaine P. M.; Dos Santos, Julie; Moreno, Céline; Devilliers, Maëlle; Maroni, Brigitte; Sueur, Cédric; Casali, Andreu; Ujvari, Beata; Thomas, Frederic; Montagne, Jacques; Mery, Frederic (Springer Nature, 2018)
      The influence of oncogenic phenomena on the ecology and evolution of animal species is becoming an important research topic. Similar to host–pathogen interactions, cancer negatively affects host fitness, which should ...
    • Social factors related to the clinical severity of influenza cases in Spain during the A (H1N1) 2009 virus pandemic 

      Mayoral, José María; Alonso, Jordi; Garín, Olatz; Herrador, Zaida; Astray, Jenaro; Baricot, Maretva; Castilla, Jesús; Cantón, Rafael; Castro, Ady; Delgado-Rodríguez, Miguel; Ferri, Alicia; Godoy i García, Pere; Gónzález-Candelas, Fernando; Martín, Vicente; Pumarola, Tomás; Quintana, José María; Soldevila, Núria; Tamames, Sonia; Domínguez García, Àngela; CIBERESP Cases and Controls in Pandemic Influenza Working Group (BioMed Central, 2013)
      Background: During the 2009 influenza pandemic, a change in the type of patients most often affected by influenza was observed. The objective of this study was to assess the role of individual and social determinants ...
    • Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009–2010 

      González-Candelas, Fernando; Astray, Jenaro; Alonso, Jordi; Castro, Ady; Cantón, Rafael; Galán, Juan Carlos; Garín, Olatz; Sáez, Marc; Soldevila, Núria; Baricot, Maretva; Castilla, Jesús; Godoy i García, Pere; Delgado-Rodríguez, Miguel; Martín, Vicente; Mayoral, José María; Pumarola, Tomás; Quintana, José María; Tamames, Sonia; Domínguez García, Àngela; CIBERESP Cases and Controls in Pandemic Influenza Working Group (Public Library of Science, 2012)
      The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza ...
    • Soluble TWEAK and atheromatosis progression in patients with chronic kidney disease 

      Fernández-Laso, V.; Méndez-Barbero, N.; Valdivielso Revilla, José Manuel; Betriu i Bars, M. Àngels; Fernández i Giráldez, Elvira; Egido, Jesús; Martín-Ventura, JL.; Blanco-Colio, LM. (Elsevier, 2017-03-31)
      BACKGROUND AND AIMS: Circulating soluble TNF-like weak inducer of apoptosis (sTWEAK) concentrations are related to the presence of chronic kidney disease (CKD) and cardiovascular disease (CVD). However, there are no data ...
    • Soluble TWEAK and Major Adverse Cardiovascular Events in Patients with CKD 

      Fernández-Laso, V.; Sastre, Cristina; Valdivielso Revilla, José Manuel; Betriu i Bars, M. Àngels; Fernández i Giráldez, Elvira; Egido, Jesús; Martín-Ventura, JL.; Blanco-Colio, LM. (American Society of Nephrology, 2016-03)
      Abstract BACKGROUND AND OBJECTIVES: Soluble TNF-like weak inducer of apoptosis (sTWEAK) is a proinflammatory cytokine belonging to the TNF superfamily. sTWEAK concentrations have been associated with the presence of CKD ...
    • ¿Son las alteraciones neuropsicológicas de los trastornos de la conducta alimentaria endofenotipos de la enfermedad? Revisión y estado actual del tema 

      Idini, Ester; Márquez Medina, Diego; Pifarré Paredero, Josep; Buj Álvarez, Imma; Castán Campanera, Ester (Viguera Editores, 2012)
      Estudios recientes reflejan que las alteraciones de la función cognitiva ejecutiva pueden ser endofenotipos de trastornos de la conducta alimentaria.
    • Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1 

      García-Morales, Victoria; Rodríguez-Bey, Guillermo; Gómez-Pérez, Laura; Domínguez-Vías, Germán; González-Forero, David; Portillo, Federico; Campos-Caro, Antonio; Gento-Caro, Ángela; Issaoui, Noura; Soler i Tatché, Rosa Ma.; Garcera, Ana; Moreno-López, Bernardo (Nature Publishing Group, 2019-08-22)
      Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium ...
    • Spanish People with Type 2 Diabetes Show an Improved Adherence to the Mediterranean Diet 

      Alcubierre Calvo, Núria; Granado Casas, Minerva; Real, Jordi; Perpiñán, Hèctor; Rubinat, Esther; Falguera, Mireia; Castelblanco Echavarría, Esmeralda; Franch-Nadal, Josep; Mauricio Puente, Dídac (MDPI, 2020)
      The aim of this study was to assess the dietary pattern (i.e., Mediterranean Diet (MedDiet) and healthy eating) in people with type 2 diabetes (T2D) compared with those without diabetes. In addition, we explored clinical ...