Now showing items 675-694 of 1089

    • Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency 

      Fico, Annalisa; Chevigny, Antoine De; Egea Navarro, Joaquim; Bösl, Michael R.; Cremer, Harold; Maina, Flavio; Dono, Rosanna (Wiley, 2012)
      Self-renewal and differentiation of stem cell depend on a dynamic interplay of cell-extrinsic and -intrinsic regulators. However, how stem cells perceive the right amount of signal and at the right time to undergo a ...
    • Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae 

      Pedroso, Nuno; Matias, Ana C.; Cyrne, Luísa; Antunes, Fernando; Borges, Carlos; Malhó, Rui; de Almeida, Rodrigo F.M.; Herrero Perpiñán, Enrique; Marinho, H. Susana (Elsevier, 2009)
      In Saccharomyces cerevisiae, the rate of hydrogen peroxide (H2O2) diffusion through the plasma membrane decreases during adaptation to H2O2 by a still unknown mechanism. Here, adaptation to H2O2 was observed to modulate ...
    • Modulatory effects of psychopathy on Wisconsin Card Sorting Test performance in male offenders with Antisocial Personality Disorder 

      Pera Guardiola, Vanessa; Batalla, Iolanda; Bosque, Javier; Kosson, David; Pifarré Paredero, Josep; Hernández-Ribas, Rosa; Goldberg, Ximena; Contreras-Rodríguez, Oren; Menchón, José M.; Soriano-Mas, Carles; Cardoner, N. (Narcís) (Elsevier, 2016)
      Neuropsychological deficits in executive functions (EF) have been linked to antisocial behavior and considered to be cardinal to the onset and persistence of severe antisocial and aggressive behavior. However, when psychopathy ...
    • Molecular and structural antioxidant defenses against oxidative stressin animals 

      Pamplona Gras, Reinald; Costantini, David (American Physiological Society, 2011)
      In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural ...
    • Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma 

      Leskelä, Susanna; Pérez-Mies, Belén; Rosa-Rosa, Juan Manuel; Cristobal, Eva; Biscuola, Michele; Palacios-Berraquero, María L.; Ong, SuFey; Matias-Guiu, Xavier; Palacios, José (MDPI, 2019)
      Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive, high-grade, metaplastic carcinoma. At the morphological level, ...
    • Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups 

      Bosse, Tjalling; Nout, Remi; McAlpine, Jessica N.; McConechy, Melissa; Britton, Heidi; Hussein, Yaser; Gonzalez, Carlene; Ganesan, Raji; Steele, Jane C.; Harrison, Beth T.; Oliva, Esther; Vidal, August; Matias-Guiu, Xavier; Abu-Rustum, Nadeem R.; Levine, Douglas A.; Gilks, C. Blake; Soslow, Robert A. (Wolters Kluwer Health, 2018)
      Our aim was to investigate whether molecular classification can be used to refine prognosis in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs were classified into 4 subgroups: p53 abnormal, based on ...
    • Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity 

      Jové Font, Mariona; Tibau, Joan; Serrano Casasola, José Carlos Enrique; Berdún Hernández, Rebeca; Rodríguez Palmero, María; Font-i-Furnols, Maria; Cassanyé, Anna; Rodriguez Mortera, Reyna; Sol, Joaquim; Rassendren, Helene; Fàbrega, Emma; Crescenti, Anna; Castell, Anna; Sabater, Mónica; Ortega, Francisco J.; Martín Garí, Meritxell; Quintanilla Aguado, Raquel; Puigjaner, Joaquim; Moreno, José Antonio; Prat, Joan; Arola i Ferrer, Lluís; Fernández Real, José Manuel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2020-09-01)
      As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed ...
    • Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer 

      Alonso-Alconada, Lorena; Muinelo-Romay, Laura; Madissoo, Kadri; Díaz-López, Antonio; Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Hapangama, Dharani; Coenegrachts, Lieve; Cano, Amparo; Gil-Moreno, Antonio; Chiva, Luís; Cueva, Juan; Vieito, María; Ortega Izquierdo, Maria Eugenia; Mariscal, Javier; Colás, Eva; Castellví, Josep; Cusido, Maite; Dolcet Roca, Xavier; Nijman, Hans W.; Bosse, Tjalling; Green, John A.; Romano, Andrea; Reventós, Jaume; López-López, Rafael; Salvesen, Helga B.; Amant, Frederic; Matias-Guiu, Xavier; Moreno-Bueno, Gema; Abal, Miguel (Biomed Central, 2014)
      Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ...
    • Molecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA) results in upstaging of a quarter of patients in a prospective, European, multicentre study. 

      Croner, R. S.; Geppert, C. I.; Bader, F. G.; Nitsche, U.; Späth, C.; Rosenberg, R.; Zettl, A.; Matias-Guiu, Xavier; Tarragona Foradada, Jordi; Güller, U.; Stürzl, M.; Zuber, M. (Cancer Research, 2014)
      Background: Current histopathological staging procedures in colon carcinomas depend on midline division of the lymph nodes with one section of haematoxylin & eosin (H&E) staining only. By this method, tumour deposits outside ...
    • Molecularly determined total tumour load in lymph nodes of stage I–II colon cancer patients correlates with high-risk factors. A multicentre prospective study 

      Aldecoa, Iban; Atares, Begoña; Tarragona Foradada, Jordi; Bernet, Laia; Sardon, Jose Domingo; Pereda, Teresa; Villar, Carlos; Mendez, M. Carmen; Gonzalez-Obeso, Elvira; Elorriaga, Kepa; Lopez Alonso, Guadalupe; Zamora, Javier; Planell, Nuria; Palacios, José; Castells, Antoni; Matias-Guiu, Xavier; Cuatrecasas, Miriam (Springer, 2016)
      Stage I–II (pN0) colorectal cancer patients are surgically treated although up to 25 % will eventually die from disease recurrence. Lymph node (LN) status is an independent prognostic factor in colorectal cancer (CRC), and ...
    • Monitoring anti-PLA2R antibody titres to predict the likelihood of spontaneous remission of membranous nephropathy 

      Jatem Escalante, Elias; Martín Conde, María Luisa; Gracia-Lavedan, Esther; Benítez, Iván; González, Jorge; Colàs Campàs, Laura; Garcia Carrasco, Alicia; Martínez Martínez, Cristina; Segarra Medrano, Alfons (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)
      Background: In anti-phospholipase A2 receptor (PLA2R) membranous nephropathy (MN) there is controversy whether spontaneous remission (SR) can be predicted using a single titre or by assessing the dynamic changes in anti-PLA2R ...
    • Monitoring patients on chronic treatment with antidepressants between 2003 and 2011: analysis of factors associated with compliance 

      Serna Arnaiz, Catalina; Real, Jordi; Cruz Esteve, María Inés; Galván, Leonardo; Martin, Elisabet (BioMed Central, 2015)
      Background: Clinical practice guidelines consider the use of antidepressants as one of the standard treatments for anxiety disorders, due to the significant improvements obtained in quality of life and functional disability. ...
    • More talk than action: Gender and ethnic diversity in leading public health universities 

      Khan, Mishal Sameer; Lakha, Fatim; Tan, Melisa Mei Jin; Singh, Shweta R.; Quek, Rina Yu Chin; Han, Emeline; Tan, See Mieng; Haldane, Victoria; Gea Sánchez, Montserrat; Legido-Quigley, Helena (Elsevier, 2019)
      Improving the career progression of women and ethnic minorities in public health universities has been a longstanding challenge, which we believe might be addressed by including staff diversity data in university rankings. ...
    • Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice 

      Blasco Carmona, Alba; Gras Artells, Sílvia; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Pereira, Suzette L.; Navarro, Xavier; Rueda, Ricardo; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Wiley, 2020-07-20)
      Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed ...
    • Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress 

      Petkova, Mima Ivanova; Pujol Carrión, Núria; Arroyo, Javier; Garcia-Cantalejo, J.; Torre Ruiz, M. A. de la (American Society for Biochemistry and Molecular Biology, 2010)
      Mtl1 is a member of the cell wall integrity (CWI) pathway of Saccharomyces cerevisiae, which functions as a cell wall sensor for oxidative stress. Genome-wide transcriptional analysis revealed a cluster of genes that were ...
    • Multi-center real-world comparison of the fully automated Idylla™ microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer 

      Velasco Sánchez, Ana; Tokat, Fatma; Bonde, Jesper; Trim, Nicola; Bauer, Elisabeth; Meeney, Adam; de Leng, Wendy; Chong, George; Dalstein, Véronique; Kis, Lorand L.; Lorentzen, Jon A.; Tomić, Snjezana; Thwaites, Keeley; Putzová, Martina; Birnbaum, Astrid; Qazi, Romena; Primmer, Vanessa; Dockhorn-Dworniczak, Barbara; Hernández-Losa, Javier; Soares, Fernando A.; Gertler, Asaf A.; Kalman, Michal; Wong, Chris; Carraro, Dirce M.; Sousa, Ana C.; Reis, Rui M.; Fox, Stephen B.; Fassan, Matteo; Brevet, Marie; Merkelbach Bruse, Sabine; Colling, Richard; Soilleux, Elizabeth; Teo, Ryan Yee Wei; D'Haene, Nicky; Nolet, Serge; Ristimäki, Ari; Väisänen, Timo; Chapusot, Caroline; Soruri, Afsaneh; Unger, Tina; Wecgowiec, Johanna; Biscuola, Michele; Frattini, Milo; Long, Anna; Campregher, Paulo V.; Matias-Guiu, Xavier (Springer-Verlag, 2021)
      Microsatellite instability (MSI) is present in 15–20% of primary colorectal cancers. MSI status is assessed to detect Lynchsyndrome, guide adjuvant chemotherapy, determine prognosis, and use as a companion test for checkpoint ...
    • Multidisciplinary virtual management of pulmonary nodules 

      Polanco, Dinora; González, Jessica; Gracia-Lavedan, Esther; Pinilla, Lucía; Plana, R.; Molina, M.; Pardina Solano, Marina Asunción; Barbé Illa, Ferran (Elsevier; Sociedade Portuguesa de Pneumologia, 2022)
      Introduction and objectives: Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the ...
    • Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs 

      Franco-Serrano, Luis; Huerta, Mario; Hernández, Sergio; Cedano, Juan; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Amela, Isaac; Querol, Enrique (Springer Verlag, 2018)
      Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ...
    • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

      Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
      Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
    • Multiple telencephalic and extratelencephalic embryonic domains contribute neurons to the medial extended amygdala 

      Bupesh, Munisamy; Legaz, Isabel; Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2011)
      Dysfunctions in emotional control and social behavior are behind human neuropsychiatric disorders, some of which are associated with an alteration of amygdalar development. The medial extended amygdala is a key telencephalic ...