Now showing items 591-610 of 906

    • Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxindeficient yeast 

      Alsina Obiols, David; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2018)
      Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in ...
    • Nivel de conocimiento de la enfermedad de Alzheimer en cuidadores y población general 

      Jorge, C.; Cetó, M.; Arias, A.; Blasco, E.; Gil, M. P.; López, R.; Dakterzada, Farida; Purroy Garcia, Francisco; Piñol Ripoll, Gerard (Elsevier, 2019-05-11)
      Introducción El conocimiento de la enfermedad de Alzheimer es fundamental para el diagnóstico precoz y para reducir la sobrecarga del cuidador. El objetivo fue evaluar el grado de conocimiento de la enfermedad de Alzheimer ...
    • Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Pamplona Gras, Reinald (MDPI, 2013)
      Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes ...
    • Non-invasive imaging techniques and assessment of carotid vasa vasorum neovascularization: promises and pitfalls 

      Pereira, Tania; Betriu i Bars, M. Àngels; Alves, Rui (Elsevier, 2018)
      Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization ...
    • Notch signaling pathway is activated in motoneurons of spinal muscular atrophy 

      Cardona-Rossinyol, Andrea; Garcera, Ana; Torres-Benito, Laura; Soler i Tatché, Rosa Ma.; Tabares, Lucía; Lladó, Jerònia; Olmos, Gabriel; Caraballo-Miralles, Víctor (MDPI, 2013)
      Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. Notch signaling is a cell-cell communication ...
    • Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxins 

      Molina Navarro, Maria Micaela; Bellí i Martínez, Gemma; Torre Ruiz, M. A. de la; Rodríguez Manzanaque, Maria Teresa; Herrero Perpiñán, Enrique (The American Society for Biochemistry and Molecular Biology, 2004)
      Glutaredoxins are thiol oxidoreductases that regulate protein redox state. In Saccharomyces cerevisiae, Grx1 and Grx2 are cytosolic dithiol glutaredoxins, whereas Grx3, Grx4, and Grx5 are monothiol glutaredoxins. ...
    • Nursing knowledge of and attitude in cardiopulmonary arrest: cross-sectional survey analysis 

      Tíscar González, Verónica; Blanco Blanco, Joan; Gea Sánchez, Montserrat; Rodriguez-Molinuevo, Ascensión; Moreno-Casbas, Maria Teresa (PeerJ, 2019)
      Background Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to ...
    • Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model 

      Berciano, Maria T.; Puente-Bedia, Alba; Medina‑Samamé, Almundena; Rodriguez-Rey, José C.; Calderó i Pardo, Jordi; Lafarga, Miguel; Tapia, Olga (Nature Publishing Group, 2020)
      Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease characterized by degeneration of spinal cord alpha motor neurons (αMNs). SMA is caused by the homozygous deletion or mutation of the ...
    • Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma 

      Cubillos‑Zapata, Carolina; Martínez‑García, Miguel Ángel; Díaz‑García, Elena; Jaureguizar, Ana; Campos‑Rodríguez, Francisco; Sánchez de la Torre, Manuel; Nagore, Eduardo; Martorell‑Calatayud, Antonio; Hernández Blasco, Luis; Pastor, Esther; Abad-Capa, Jorge; Montserrat, Josep Maria; Cabriada‑Nuño, Valentín; Cano‑Pumarega, Irene; Corral-Peñafiel, Jaime; Arias, Eva; Mediano, Olga; Somoza, María; Dalmau-Arias, Joan; Almendros, Isaac; Farré, Ramon; López‑Collazo, Eduardo; Gozal, David; García Río, Francisco (Nature Research, 2020)
      Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases ...
    • Obesity changes the human gut mycobiome 

      Portero Otín, Manuel; Pamplona Gras, Reinald; Jové Font, Mariona; Rodríguez, M. Mar; Pérez, Daniel; Chaves, Felipe Javier; Esteve, Eduardo; Marin-Garcia, Pablo; Xifra, Gemma; Vendrell, Joan; Ricart, Wifredo; Chacón, Matilde R.; Fernández Real, José Manuel (Nature Publishing Group, 2015)
      The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in ...
    • Obesity, a Diet-Induced Inflammatory Disease 

      Lecube Torelló, Albert; López Cano, Carolina (MDPI, 2019)
    • Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways 

      Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Contreras-Rodríguez, Oren; Burokas, Aurelijus; Ortega Sánchez, Juan Antonio; Blasco Solà, Gerard; Coll, Claudia; Biarnés, Carles; Castells Nobau, Anna; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Barretina Ginesta, Jordi; Gich Fullà, Jordi; Pérez Brocal, Vicente; Moya, Andrés; Fernández Real, Xavier; Ramió Torrentà, Lluís; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Maldonado, Rafael; Fernández Real, José Manuel (BMJ Publishing GroupBritish Society of Gastroenterology, 2021-01)
      Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We ...
    • Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a Spanish chronic kidney disease cohort: baseline data from the NEFRONA study 

      Arroyo, David; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Vidal Amat, Teresa; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (BioMed Central, 2014)
      Background: Cardiovascular events (CVE) are more prevalent in chronic kidney disease (CKD) than in general population, being the main cause of morbimortality. Specific risk factors related to CKD have been suggested, because ...
    • Obstructive Sleep Apnea: Emerging Treatments Targeting the Genioglossus Muscle 

      Mediano, Olga; Romero-Peralta, Sofia; Resano, Pilar; Cano-Pumarega, Irene; Sánchez de la Torre, Manuel; Castillo-García, María; Martínez-Sánchez, Ana Belén; Ortigado, Ana; García-Río, Francisco (MDPI, 2019)
      Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway obstruction caused by a loss of upper airway dilator muscle tone during sleep and an inadequate compensatory response by these muscles ...
    • Obstructive sleep apnea: in search of precision 

      Sánchez de la Torre, Manuel; Gozal, David (Taylor & Francis, 2017)
      Introduction: Obstructive sleep apnea (OSA) is a highly prevalent condition that is viewed as a major global health concern, while affecting approximately 10% of the middle-aged population. OSA is a chronic disease that ...
    • Occupational Precariousness of Nursing Staff in Catalonia's Public and Private Nursing Homes 

      Fité Serra, Ana Mari; Gea Sánchez, Montserrat; Alconada Romero, Álvaro; Mateos, José Tomás; Blanco Blanco, Joan; Barallat Gimeno, Eva; Roca Llobet, Judith; Muntaner, Carles (MDPI, 2019-12-05)
      Abstract: Nursing sta who provide care in the nursing homes of Catalonia have more precarious work conditions, including more demanding schedules and work overload, than those in other areas of care. This situation entails ...
    • Ocular Inflammation 

      Huerva, Valentín; Ascaso, Francisco J.; Grzybowski, Andrzej (Hindawi Publishing Corporation, 2015)
    • Olfactory and amygdalar structures of the chicken ventral pallium based on the combinatorial expression patterns of LIM and other developmental regulatory genes 

      Abellán Ródenas, Antonio; Legaz, Isabel; Vernier, Baptiste; Rétaux, Sylvie; Medina Hernández, Loreta Mª (Wiley, 2009)
      We compared the combinatorial expression patterns of several LIM domain-containing regulatory genes in the ventrolateral pallium of mouse and chicken, in order to identify the homologues of the ventral pallial amygdala ...
    • Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues 

      Maiques Carlos, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius Calderó, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)
      In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ...
    • Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae 

      Bellí i Martínez, Gemma; Garí Marsol, Eloi; Aldea, Martí; Herrero Perpiñán, Enrique (Blackwell Science, 2001)
      Moderate hyperosmotic stress on Saccharomyces cerevisiae cells produces a temporary delay at the G1 stage of the cell cycle. This is accompanied by transitory downregulation of CLN1, CLN2 and CLB5 transcript levels, ...