Now showing items 553-572 of 935

    • Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential 

      Prieto, Ignacio; Rubio Alarcón, Carmen; García-Gómez, Raquel; Berdún Hernández, Rebeca; Urgel, Tamara; Portero Otín, Manuel; Pamplona Gras, Reinald; Martínez-Ruiz, Antonio; Ruiz-Sanz, José Ignacio; Ruiz-Larrea, M. Begoña; Jové Font, Mariona; Cerdán, Sebastián; Monsalve, María (Elsevier, 2020-01-01)
      PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...
    • Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1 

      Moreno Cermeño, Armando J.; Alsina Obiols, David; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Elsevier, 2013)
      Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ...
    • Metabolomic and lipidomic profiling identifies the role of the RNA editing pathway in endometrial carcinogenesis 

      Altadill, Tatiana; Dowdy, Tyrone M.; Gill, Kirandeep; Reques, Armando; Menon, Smrithi S.; Moiola, Cristian P.; Lopez-Gil, Carlos; Coll, Eva; Matias-Guiu, Xavier; Cabrera, Silvia; Garcia, Angel; Reventos, Jaume; W. Byers, Stephen; Gil-Moreno, Antonio; Cheema, Amrita K.; Colás, Eva (Nature Publishing Group, 2017)
      Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
    • Metabolomics predicts stroke recurrence after transient ischemic attack 

      Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)
      Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
    • La metabolómica en el ictus isquémico, nuevos biomarcadores diagnósticos y pronósticos 

      Mauri-Capdevila, Gerard; Jové Font, Mariona; Suárez-Luis, Idalmis; Portero Otín, Manuel; Purroy Garcia, Francisco (Viguera Editores, 2013)
      El estudio de biomarcadores relacionados con el ictus isquémico está adquiriendo una mayor importancia en vistas de conocer mejor los cambios fisiopatológicos de la enfermedad cerebrovascular y facilitar un diagnóstico ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
    • Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women 

      Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Pamplona Gras, Reinald; Victor, Victor M.; Jové Font, Mariona (Nature Publishing Group, 2019-11-05)
      Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ...
    • Method for Improving EEG Based Emotion Recognition by Combining It with Synchronized Biometric and Eye Tracking Technologies in a Non-invasive and Low Cost Way 

      López Gil, Juan Miguel; Virgili Gomà, Jordi; Gil Iranzo, Rosa María; García González, Roberto; Guilera Lladós, Teresa; Batalla, Iolanda; Soler González, Jorge (Frontiers in Computational Neurosciencie, 2016)
      Technical advances, particularly the integration of wearable and embedded sensors, facilitate tracking of physiological responses in a less intrusive way. Currently, there are many devices that allow gathering biometric ...
    • Methods for and results from the study of design principles in molecular systems 

      Salvadó López, Baldiri; Karathia, Hiren; Usié Chimenos, Anabel; Vilaprinyo Terré, Ester; Omholt, Stig; Sorribas Tello, Albert; Alves, Rui (Elsevier, 2011)
      Most aspects of molecular biology can be understood in terms of biological design principles. These principles can be loosely defined as qualitative and quantitative features that emerge in evolution and recur more ...
    • Microangiopathy of common carotid vasa vasorum in type 1 diabetes mellitus 

      Rubinat, Esther; Ortega, Emilio; Traveset Maeso, Alicia; Arcidiacono, Maria V.; Alonso, Núria; Betriu i Bars, M. Àngels; Granado Casas, Minerva; Hernández García, Marta; Soldevila, Jordi; Puig-Domingo, Manuel; Jurjo Campo, Carmen; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (Elsevier, 2015-06-01)
      Objective: We hypothesize that in type 1 diabetes vasa vasorum (VV) are affected by microangiopathic changes. For this purpose, we assessed the status of the VV signal in patients with type 1 diabetes. Methods: The VV ...
    • Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury 

      Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Tarabal Mostazo, Olga; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley, 2021-01-02)
      Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, ...
    • Migrated t lymphocytes into malignant pleural effusions: an indicator of good prognosis in lung adenocarcinoma patients 

      Nieto, Juan C.; Zamora, Carlos; Porcel Pérez, José Manuel; Mulet, Maria; Pajares, Virginia; Muñoz-Fernandez, Ana M.; Calvo, Nuria; Espinosa, Iñigo; Pascual-García, Mónica; Bielsa Martín, Silvia; Vidal, Silvia (Nature Publishing Group, 2019)
      The presence of leukocyte subpopulations in malignant pleural effusions (MPEs) can have a different impact on tumor cell proliferation and vascular leakiness, their analysis can help to understand the metastatic microenvironment. ...
    • Mineral metabolism factors predict accelerated progression of common carotid intima-media thickness in chronic kidney disease: the NEFRONA study 

      Abajo, María; Betriu i Bars, M. Àngels; Arroyo, David; Gracia, Marta; Pino, María Dolores del; Martínez, Isabel; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Oxford University Press, 2017-08-27)
      BACK GROUND: The leading cause of premature death in chronic kidney disease (CKD) is cardiovascular disease (CVD), but risk assessment in renal patients is challenging. The aim of the study was to analyse the factors that ...
    • Minimization of biosynthetic costs in adaptive gene expression responses of yeast to environmental changes 

      Vilaprinyo Terré, Ester; Alves, Rui; Sorribas Tello, Albert (Public Library of Science (PLoS), 2010)
      Yeast successfully adapts to an environmental stress by altering physiology and fine-tuning metabolism. This fine-tuning is achieved through regulation of both gene expression and protein activity, and it is shaped by ...
    • Mitochondria and ageing 

      Leeuwenburgh, Christiaan; Pamplona Gras, Reinald; Sanz, Alberto (Hindawi Publishing Corporation, 2011)
    • Mitochondrial ATP-Synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology 

      Terni, Beatrice; Boada Pallàs, Jordi; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2010)
      Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Several proteins have been identified as targets of oxidative damage in AD dementia (usually ...
    • Mitochondrial calcium signaling and neurodegenerative diseases 

      Britti, Elena; Delaspre, Fabien; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press, 2018-11-16)
      Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium ...
    • Mitochondrial DNA damage and animal longevity: insights from comparative studies 

      Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2011)
      Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur, even under physiological ...
    • Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice 

      Hiona, Asimina; Sanz, Alberto; Kujoth, Gregory C.; Pamplona Gras, Reinald; Seo, Arnold Y.; Hofer, Tim; Someya, Shinichi; Miyakawa, Takuya; Nakayama, Chie; Samhan-Arias, Alejandro K.; Servais, Stephane; Barger, Jamie L.; Portero Otín, Manuel; Tanokura, Masaru; Prolla, Tomas A.; Leeuwenburgh, Christiaan (Public Library of Science (PLoS), 2010)
      Background: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no ...