Now showing items 510-529 of 906

    • Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters 

      Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Arola i Ferrer, Lluís; Caimari, Antoni; Bas, Josep M. del; Crescenti, Anna; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford Journals, 2013)
      Aims Atherosclerosis is the main pathological process contributing to cardiovascular disease, with diet being the most important factor involved. Although the lipidome of atheromatous plaque has been studied previously, ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome 

      Jové Font, Mariona; Pradas Barriga, Irene; Naudí i Farré, Alba; Rovira-Llopis, Susana; Bañuls, Celia; Rocha, Milagros; Portero Otín, Manuel; Hernández-Mijares, Antonio; Victor, Victor M.; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors ...
    • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

      Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
      The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...
    • Liquid biopsy by NGS: differential presence of exons (DPE) in cell-free DNA reveals different patterns in metastatic and nonmetastatic colorectal cancer 

      Olmedillas-López, Susana; García-Olmo, Dolores C.; García-Arranz, Mariano; Peiró-Pastor, Ramón; Aguado, Begoña; García-Olmo, Damián (Wiley Open Access, 2018)
      Next-generation sequencing (NGS) has been proposed as a suitable tool for liquid biopsy in colorectal cancer (CRC), although most studies to date have focused almost exclusively on sequencing of panels of potential clinically ...
    • Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair 

      Salvany, Sara; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Hernández, Sara; Santafé Martínez, Manel; Soto-Bernardini, María Clara; Calderó i Pardo, Jordi; Schwab, Markus H.; Esquerda Colell, Josep (Federation of American Societies for Experimental Biology, 2019)
      C-type synaptic boutons (C-boutons) provide cholinergic afferent input to spinal cord motor neurons (MNs), which display an endoplasmic reticulum (ER)–related subsurface cistern (SSC) adjacent to their postsynaptic membrane. ...
    • Localization of peroxisome proliferator-activated receptor alpha (PPARa) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus 

      Rivera, Patricia; Arrabal, Sergio; Vargas, Antonio; Blanco Calvo, Eduardo; Serrano, Antonia; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers Media S.A., 2014-03-17)
      The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARα receptors, and their presence requires the activation of a specific phospholipase D ...
    • Location-dependent effects of trauma on oxidative stress in humans 

      Servià Goixart, Lluís; Serrano Casasola, José Carlos Enrique; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (Public Library of Science, 2018)
      Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. ...
    • Long lifespans have evolved with long and monounsaturated fatty acids in birds 

      Galván, Ismael; Naudí i Farré, Alba; Erritzøe, Johannes; Møller, Anders P.; Barja, Gustavo; Pamplona Gras, Reinald (Society for the Study of EvolutionWiley, 2015)
      The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we ...
    • Long-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Study 

      Navarro-Soriano, Cristina; Martínez-García, Miguel Angel; Torres, Gerard; Barbé Illa, Ferran; Sánchez de la Torre, Manuel; Caballero-Eraso, Candela; Lloberes, Patricia; Díaz Cambriles, Trinidad; Somoza, María; Masa, Juan F.; González, Mónica; Mañas, Eva; de la Pena, Mónica; García-Río, Francisco; Montserrat, Josep Maria; Muriel, Alfonso; Oscullo, Grace; García-Ortega, Alberto; Posadas, Tomás; Campos-Rodríguez, Francisco; Spanish Sleep Network (Elsevier, 2020)
      Background: There is some controversy about the effect of continuous positive airway pressure (CPAP) on the incidence of cardiovascular events (CVE). However, the incidence of CVE among patients with both obstructive sleep ...
    • Long-term Noninvasive Ventilation in Obesity Hypoventilation Syndrome Without Severe OSA: The Pickwick Randomized Controlled Trial 

      Masa, Juan F.; Benítez, Iván; Sánchez-Quiroga, Maria Á.; Gomez de Terreros, Francisco J.; Corral-Peñafiel, Jaime; Romero, Auxiliadora; Caballero-Eraso, Candela; Alonso-Álvarez, Maria L.; Ordax-Carbajo, Estrella; Gomez-Garcia, Teresa; González, Mónica; López-Martín, Soledad; Marin, José M.; Martí, Sergi; Díaz Cambriles, Trinidad; Chiner, Eusebi; Egea, Carlos; Barca, Javier; Vázquez-Polo, Francisco Javier; Negrín, Miguel Ángel; Martel-Escobar, María; Barbé Illa, Ferran; Mokhlesi, Babak; Spanish Sleep Network (Elsevier, 2020-04-25)
      Background: Noninvasive ventilation (NIV) is an effective form of treatment in obesity hypoventilation syndrome (OHS) with severe obstructive sleep apnea (OSA). However, there is paucity of evidence in OHS patients without ...
    • Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance 

      Fourcade, Stéphane; Morató, Laia; Parameswaran, Janani; Ruiz, Montserrat; Ruiz-Cortés, Tatiana; Jové Font, Mariona; Naudí i Farré, Alba; Martínez, Paloma; Dierssen, Mara; Ferrer, Isidre; Villarroya, Francesc; Pamplona Gras, Reinald; Vaquero, Alejandro; Portero Otín, Manuel; Pujol, Aurora (Wiley, 2017)
      Sirtuin 2 (SIRT2) is a member of a family of NAD+-dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and ...
    • Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Sanchez, Isabel; Gómez, José; Naudí i Farré, Alba; Barja, Gustavo; Pamplona Gras, Reinald (Elsevier, 2020-07-01)
      Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to ...
    • Low-Carbohydrate diet for the treatment of gestational Diabetes Mellitus 

      Moreno Castilla, Cristina; Hernandez, Marta; Bergua, Mercè; Álvarez, Maria C.; Arce, Maria A.; Rodríguez, Karen; Martínez Alonso, Montserrat; Iglesias Durán, Montserrat; Mateu, Magdalena; Santos, Maria D.; Pacheco, Linda R.; Blasco, Yolanda; Martín, Eva; Balsells, Núria; Aranda, Núria; Mauricio Puente, Dídac (American Diabetes Association, 2013)
      OBJECTIVE: Medical nutrition therapy based on the control of the amount and distribution of carbohydrates (CHO) is the initial treatment for gestational diabetes mellitus (GDM), but there is a need for randomized controlled ...
    • Low-Dose Spironolactone-Pioglitazone-Metformin Normalizes Circulating Fetuin-A Concentrations in Adolescent Girls with Polycystic Ovary Syndrome 

      Díaz, Marta; Gallego-Escuredo, José M.; López-Bermejo, Abel; de Zegher, Francis; Villarroya, Francesc; Ibáñez, Lourdes (Hindawi, 2018)
      Background: Fetuin-A is a glycoprotein produced in the liver and related to metabolic syndrome; fetuin-A secretion is divergently regulated in different pathological conditions. In girls with polycystic ovary syndrome ...
    • Lower hemoglobin concentration is associated with retinal ischemia and the severity of diabetic retinopathy in type 2 diabetes 

      Traveset Maeso, Alicia; Rubinat, Esther; Ortega, Emilio; Alcubierre Calvo, Núria; Vazquez, Beatriz; Hernández García, Marta; Jurjo Campo, Carmen; Espinet, Ramon; Ezpeleta, Juan Antonio; Mauricio Puente, Dídac (Hindawi Publishing Corporation, 2016)
      Aims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM). Methods. ...
    • Machine learning techniques for mortality prediction in critical traumatic patients: anatomic and physiologic variables from the RETRAUCI study 

      Servià Goixart, Lluís; Montserrat, Neus; Badia Castello, Mariona; Llompart-Pou, Juan Antonio; Barea-Mendoza, Jesús Abelardo; Chico-Fernández, Mario; Sánchez-Casado, Marcelino; Jiménez, José Manuel; Mayor, Dolores María; Trujillano Cabello, Javier (BMC, 2020-10-20)
      Interest in models for calculating the risk of death in traumatic patients admitted to ICUs remains high. These models use variables derived from the deviation of physiological parameters and/or the severity of anatomical ...
    • Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins 

      Irazusta, Verónica Patricia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2008)
      Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ...
    • Malignant pleural effusion: from bench to bedside 

      Psallidas, Ioannis; Kalomenidis, Ioannis; Porcel Pérez, José Manuel; Robinson, Bruce W.; Stathopoulos, Georgios T. (European Respiratory Society, 2016)
      Malignant pleural effusion (MPE) is a common but serious condition that is related with poor quality of life, morbidity and mortality. Its incidence and associated healthcare costs are rising and its management remains ...
    • Managing an online survey about influenza vaccination in primary healthcare workers 

      Toledo, Diana; Aerny, Nicole; Soldevila, Núria; Baricot, Maretva; Godoy i García, Pere; Castilla, Jesús; García-Gutiérrez, Susana; Torner Gràcia, Núria; Astray, Jenaro; Mayoral, José María; Tamames, Sonia; González-Candelas, Fernando; Martín, Vicente; Díaz, José; Domínguez García, Àngela (MDPI, 2015)
      Online surveys are increasingly used due to their speed and efficiency. The aim of this study was to analyze factors that may have contributed to the quality and speed of response of an online survey on influenza vaccination ...