Browsing Articles publicats (IRBLleida) by Title
Now showing items 51-70 of 1060
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Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients
(European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)Background: Chronic kidney disease (CKD) patients have a high burden of atheromatous cardiovascular disease (ASCVD) not fully explained by traditional lipid parameters. Lipoprotein composition and subclass particle number ... -
Advanced lipoprotein profle disturbances in type 1 diabetes mellitus: a focus on LDL particles
(BioMed Central, 2020)Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profle in T1DM individuals, and analysed ... -
Adverse effects of a SOD1-peptide immunotherapy on SOD1(G93A) mouse slow model of amyotrophic lateral sclerosi
(Elsevier, 2015-12-01)Previous reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). ... -
Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age
(MDPI, 2021-11-20)Lipids are closely associated with brain structure and function. However, the potential changes in the lipidome induced by aging remain to be elucidated. In this study, we used chromatographic techniques and a mass ... -
Age-related macular degeneration in the aspect of chronic low-grade inflammation (Pathophysiological ParaInflammation)
(Hindawi Publishing Corporation, 2014)The products of oxidative stress trigger chronic low-grade inflammation (pathophysiological parainflammation) process in AMD patients. In early AMD, soft drusen contain many mediators of chronic low-grade inflammation such ... -
Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
(Wiley Open Access, 2018)Fibroblast growth factor 21 (FGF21) has been proposed to be an antiaging hormone on the basis of experimental studies in rodent models. However, circulating FGF21 levels are increased with aging in rodents and humans. ... -
AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia
(MDPI, 2017)The AKT (protein kinase B, PKB) family has been shown to participate in diverse cellular processes, including apoptosis. Previous studies demonstrated that protein kinase B2 (AKT2 − / − ) mice heart was sensitized to ... -
Alopecias cicatriciales
(Elsevier, 2012)Las alopecias cicatriciales constituyen un grupo de trastornos que dan lugar a una pérdida permanente de cabello como consecuencia de diversos procesos. En este artículo nos centraremos en las alopecias cicatriciales ... -
El alta voluntaria y la fuga en los servicios de urgencias: un reto con implicaciones éticas y médico-legales
(Sociedad Española de Medicina de Urgencias y Emergencias (SEMES), 2018) -
Alterations in one-carbon metabolism in celiac disease
(MDPI, 2020-12-01)Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ... -
Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy
(Oxford University Press, 2015)X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ... -
Altered intracellular calcium homeostasis and endoplasmic reticulum redox state in Saccharomyces cerevisiae cells lacking Grx6 glutaredoxin
(American Society for Cell Biology, 2015)Glutaredoxin 6 (Grx6) of Saccharomyces cerevisiae is an integral thiol oxidoreductase protein of the endoplasmic reticulum/Golgi vesicles. Its absence alters the redox equilibrium of the reticulum lumen toward a more ... -
Ambulatory monitoring in the diagnosis and management of obstructive sleep apnoea syndrome
(European Respiratory Society, 2013)Obstructive sleep apnoea (OSA) is a highly prevalent disorder associated with complications such as arterial hypertension, cardiovascular diseases and traffic accidents. The resources allocated for OSA are insufficient ... -
Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst
(Elsevier, 2011)We studied the effects of Amphotericin B (AmB) on Cryptococcus neoformans using different viability methods (CFUs enumeration, XTT assay and propidium iodide permeability). After 1 h of incubation, there were no viable ... -
An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain
(BioMed Central, 2013)Background: The aim of this study was to evaluate the calibration and discriminatory power of three predictive models of breast cancer risk. Methods: We included 13,760 women who were first-time participants in the ... -
An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death
(American Society for Biochemistry and Molecular Biology, 2015)Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling ... -
An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation
(Wiley, 2014)We have developed an assay based on rice embryogenic callus for rapid functional characterization of metabolic genes. We validated the assay using a selection of well-characterized genes with known functions in the carotenoid ... -
An inducible knockout mouse to model the cellautonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
(Company of Biologists, 2013)PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple ... -
An international consensus definition of the wish to hasten death and its related factors
(Public Library of Science, 2016)Background: The desire for hastened death or wish to hasten death (WTHD) that is experienced by some patients with advanced illness is a complex phenomenon for which no widely accepted definition exists. This lack of a ... -
An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation in Nuclear Respiratory Factor 1 (Nrf1) Altering the DNA Methylation State and Correct Embryonic Development
(MDPI, 2021)We have established a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify novel genes playing a role in epigenetic regulation in mammals. We hypothesize that the ENU mutagenesis screen will lead to the ...