Now showing items 404-423 of 935

    • Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment 

      Britti, Elena; Delaspre, Fabien; Feldman, Anat; Osborne, Melissa; Greif, Hagar; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley Open Access, 2018)
      Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to reduce the deleterious effects of ...
    • FRAX tool, the WHO algorithm to predict osteoporotic fractures: the first analysis of its discriminative and predictive ability in the Spanish FRIDEX cohort 

      Azagra, Rafael; Roca, Genís; Encabo, Gloria; Aguyé, Amada; Zwart, Marta; Güell, Sílvia; Puchol, Núria; Gene, Emili; Casado, Enrique; Sancho, Pilar; Solà, Silvia; Torán, Pere; Iglesias, Milagros; Gisbert, Maria Carmen; López-Expósito, Francesc; Pujol Salud, Jesús; Fernandez-Hermida, Yolanda; Puente, Ana; Rosàs, Mireia; Bou, Vicente; Antón, Juan José; Lansdberg, Gustavo; Martín-Sánchez, Juan Carlos; Díez-Pérez, Adolf; Prieto-Alhambra, Daniel (BioMed Central, 2012)
      Background: The WHO has recently published the FRAX tool to determine the absolute risk of osteoporotic fracture at 10 years. This tool has not yet been validated in Spain. Methods/design: A prospective observational ...
    • From seabed to bedside: a review on promising marine anticancer compounds 

      Wang, Edina; Sorolla Bardají, Maria Alba; Gopal Krishnan, Priya Darshini; Sorolla, Anabel (MDPI, 2020)
      The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. ...
    • Functional Connectivity Bias in the Prefrontal Cortex of Psychopaths 

      Contreras-Rodríguez, Oren; Pujol Salud, Jesús; Batalla, Iolanda; Harrison, Ben J.; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Macià, Dídac; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Elsevier, 2015)
      BACKGROUND: Psychopathy is characterized by a distinctive interpersonal style that combines callousunemotional traits with inflexible and antisocial behavior. Traditional emotion-based perspectives link emotional impairment ...
    • Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory 

      García-Casas, Ana; García-Olmo, Dolores C.; García-Olmo, Damián (Baishideng Publishing Group, 2017)
      Metastasis is the major cause of mortality in cancer disease and still constitutes one of the most controversial mechanism, not yet fully understood. What is almost beyond doubt is that circulatory system is crucial for ...
    • Ganancia de peso durante el confinamiento por la COVID-19; encuesta de la Sociedad Española de Obesidad 

      López de la Torre, Martín; Bellido, Diego; Monereo, Susana; Lecube Torelló, Albert; Sánchez Peña, Enric; Tinahones, Francisco José (Sociedad Española de Cirugía de Obesidad y Metabólica y Sociedad Española para el Estudio de la Obesidad, 2020-11-01)
      La obesidad, después de la edad, es el principal factor de mal pronóstico durante la infección por la COVID-19. El confinamiento al que la población española ha sido expuesta durante varias semanas puede ser una causa de ...
    • GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1 

      Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A.; Real, Francisco X.; Iacobuzio-Donahue, Christine A. (Public Library of Science, 2011)
      Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
    • Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; Garí Marsol, Eloi; Barja, Gustavo; Pamplona Gras, Reinald (Springer, 2020-08-01)
      Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ...
    • Genetic and experimental evidence supports the continuum of the central extended amygdala and a mutiple embryonic origin of its principal neurons 

      Bupesh, Munisamy; Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2011)
      The central extended amygdala is the major output center for telencephalic control of ingestion, fear responses, stress, and anxiety. In spite of the abundant data supporting the similarity in neurochemistry, connections, and ...
    • Genetic associations of the vitamin D and antiviral pathways with natural resistance to HIV-1 infection are influenced by interpopulation variability 

      Aguilar-Jiménez, Wbeimar; Zapata, Wildeman; Rivero-Juárez, Antonio; Pineda, Juan Antonio; Laplana Lafaja, Marina; Taborda, Natalia A.; Biasin, Mara; Clerici, Mario; Caruz, Antonio; Fibla Palazón, Joan; Rugeles, Maía T. (Elsevier, 2019)
      Vitamin D (VitD) may modulate anti-HIV-1 responses modifying the risk to acquire the HIV-1-infection. We performed a nested case-control exploratory study involving 413 individuals; HIV-1-exposed seropositives (cases) and ...
    • Genetic identification of the central nucleus and other components of the central extended amygdala in chicken during development 

      Vicario Andrade, Alba; Abellán Ródenas, Antonio; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media S.A., 2014-09-10)
      In mammals, the central extended amygdala shows a highly complex organization, and is essential for animal survival due to its implication in fear responses. However, many aspects of its evolution are still unknown, and ...
    • Genetic structure of the Spanish population 

      Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; Rivero, M. Carmen; Salinas, Ana; Ramírez-Lorca, Reposo; Morón, Francisco J.; Royo Sánchez-Palencia, José Luis; Moreno-Rey, Concha; Velasco, Juan; Carrasco, José M.; Molero, Eva; Ochoa, Carolina; Ochoa, María Dolores; Gutiérrez, Marta; Reina, Mercedes; Pascual, Rocío; Romo-Astorga, Alejandro; Susillo-González, Juan Luis; Vázquez, Enrique; Real, Luis M.; Ruiz, Agustín; Serrano-Ríos, Manuel (BioMed Central, 2010-05-25)
      Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. ...
    • Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study 

      Ciudin, Andreea; Fidilio, Enzamaria; Ortiz, Angel; Pich, Sara; Salas, Eduardo; Mesa, Jordi; Hernández, Cristina; Simó-Servat, Olga; Lecube Torelló, Albert (MDPI, 2019)
      Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of ...
    • Genetic variability in geographic populations of the natterjack toad (Bufo calamita) 

      Oromí Farrús, Neus; Richter-Boix, A; Sanuy i Castells, Delfí; Fibla Palazón, Joan (Wiley Open Access, 2012)
      Across altitudinal and latitudinal gradients, the proportion of suitable habitats varies, influencing the individual dispersal that ultimately can produce differentiation among populations. The natterjack toad (Bufo ...
    • Genoarchitecture of the extended amygdala in zebra finch, and expression of FoxP2 in cell corridors of different genetic profile 

      Vicario Andrade, Alba; Mendoza, Ezequiel; Abellán Ródenas, Antonio; Scharff, Constance; Medina Hernández, Loreta Mª (Springer Verlag, 2016)
      We used a battery of genes encoding transcription factors (Pax6, Islet1, Nkx2.1, Lhx6, Lhx5, Lhx9, FoxP2) and neuropeptides to study the extended amygdala in developing zebra finches. We identified different components of ...
    • Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer’s disease 

      Sáez, M. E.; González-Pérez, Antonio; Hernández-Olasagarre, B.; Beà Tàrrega, Aida; Moreno-Grau, S.; de Rojas, I.; Monté-Rubio, G.; Orellana, A.; Valero, S.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Ruiz, Agustín (Nature Publishing Group, 2019)
      Echocardiography has become an indispensable tool for the study of heart performance, improving the monitoring of individuals with cardiac diseases. Diverse genetic factors associated with echocardiographic measures have ...
    • Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain 

      Cullell, Natalia; Carrera, Caty; Muiño, Elena; Torres-Aguila, Nuria-Paz; Cárcel-Márquez, Jara; González-Sánchez, Jonathan; Gallego Fabrega, Cristina; Molina, Jessica; Besora, Sarah; Sotoca, Javier; Buongiorno, Maria-Teresa; Jiménez-Conde, Jordi; Giralt-Steinhauer, Eva; de Torres-Chacón, Reyes; Montaner, Joan; Mancha, Fernando; Cabezas, Juan A.; Martí Fàbregas, Joan; Prats Sánchez, Luis; Camps Renom, Pol; Purroy Garcia, Francisco; Cambray Carner, Serafí; Freijo, María del Mar; Vives-Bauzá, Cristòfol; Tur, Silvia; Font, Maria-Àngels; López-Cancio, Elena; Hernandez-Perez, Maria; Obach, Victor; Calleja, Ana; Arenillas, Juan; Rodríguez-Yáñez, Manuel; Castillo, José; Sobrino, Tomas; Fernández-Cádenas, Israel; Krupinski, Jerzy (Nature Publishing Group, 2020)
      Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms ...
    • Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population 

      Brebi, Priscilla; Maldonado, Leonel; Noordhuis, Maartje G.; Ili, Carmen; Leal, Pamela; Garcia, Patricia; Brait, Mariana; Ribas i Fortuny, Judit; Michailidi, Christina; Perez, Jimena; Soudry, Ethan; Tapia, Oscar; Guzman, Pablo; Muñoz, Sergio; Van Neste, Leander; Van Criekinge, Wim; Irizarry, Rafael; Sidransky, David; Roa, Juan C.; Guerrero-Preston, Rafael (Taylor & Francis, 2014-02-01)
      Cervical cancer is a major health concern among women in Latin America due to its high incidence and mortality. Therefore, the discovery of molecular markers for cervical cancer screening and triage is imperative. The aim ...
    • Genomic profiling of primary and recurrent adult granulosa cell tumors of the ovary 

      Gatius Calderó, Sònia; Cruz Paula, Arnaud Da; Silva, Edaise M. da; Segura, Sheila E.; Pareja, Fresia; Bi, Rui; Selenica, Pier; Kim, Sarah H.; Ferrando, Lorenzo; Vahdatinia, Mahsa; Soslow, Robert A.; Vidal, August; Przybycin, Christopher G.; Abu-Rustum, Nadeem R.; Matias-Guiu, Xavier; Rubin, Brian P.; Reis-Filho, Jorge S.; DeLair, Deborah F.; Weigelt, Britta (2020)
      Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97% of cases. These tumors are considered to have a favorable ...
    • Genotyping of common SIRPB1 copy number variant using Paralogue Ratio Test coupled to MALDI-MS quantification 

      Royo Sánchez-Palencia, José Luis; Pascual Pons, Mariona; Lupiañez, Arantxa; Sanchez Lopez, Isabel; Fibla Palazón, Joan (Elsevier, 2015)
      Copy number variant (CNV) regions have been proven to have a significant impact on gene expression. Some of them have been also found to be associated to different human diseases. CNV genotyping is often prone to error and ...