Now showing items 41-60 of 906

    • Adaptation and Validation of the Diabetic Foot Ulcer Scale-Short Form in Spanish Subjects 

      Martínez González, María Dolores; Dòria, Montserrat; Martínez Alonso, Montserrat; Alcubierre Calvo, Núria; Valls, Joan; Verdú-Soriano, José; Granado Casas, Minerva; Mauricio Puente, Dídac (MDPI, 2020)
      Diabetic foot ulcer (DFU) is a chronic complication that negatively affects the quality of life (QoL) of diabetic patients. In Spain, there is no specifically designed and validated instrument to assess the QoL of patients ...
    • Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential 

      Serrano Casasola, José Carlos Enrique; Baena-Fustegueras, Juan A; Martín Garí, Meritxell; Rassendren, Helene; Cassanyé, Anna; Naudí i Farré, Alba; López Cano, Carolina; Sánchez Peña, Enric; Fuente Juárez, Mari Cruz de la; Herrería González, Fernando; Olsina Kissler, Jorge Juan; Lecube Torelló, Albert; Portero Otín, Manuel (Wiley online library, 2019-05)
      Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ...
    • Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence 

      Moreno-Navarrete, José María; Liñares-Pose, Laura; Sabater, Mónica; Rial-Pensado, Eva; Comas, Ferran; Jové Font, Mariona; Latorre, Jèsica; Ortega Delgado, Francisco José; Ricart, Wifredo; Portero Otín, Manuel; López, Miguel; Fernández Real, José Manuel (Karger Publishers Open Access, 2018-11-18)
      Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ...
    • Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium 

      Chang, Alex R.; Grams, Morgan E.; Ballew, Shoshana H.; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M.; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J.; Li, Yuanying; Navaneethan, Sankar D.; Roderick, Paul J; Valdivielso Revilla, José Manuel; Visseren, Frank L. J.; Zhang, Luxia; Gansevoort, Ron T.; Hallan, Stein I.; Levey, Andrew S.; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark (BMJ Publishing Group, 2019)
      OBJECTIVE To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality. DESIGN ...
    • Advanced lipoprotein profle disturbances in type 1 diabetes mellitus: a focus on LDL particles 

      Amor, Antonio J.; Castelblanco Echavarría, Esmeralda; Hernández, Marta; Gimenez, Marga; Granado Casas, Minerva; Blanco, Jesús; Soldevila, Berta; Esmatjes, Enric; Conget, Ignacio; Alonso, Núria; Ortega, Emilio; Mauricio Puente, Dídac (BioMed Central, 2020)
      Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profle in T1DM individuals, and analysed ...
    • Adverse effects of a SOD1-peptide immunotherapy on SOD1(G93A) mouse slow model of amyotrophic lateral sclerosi 

      Sábado, J.; Casanovas i Llorens, Anna; Rodrigo, H.; Arqué, G.; Esquerda Colell, Josep (Elsevier, 2015-12-01)
      Previous reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). ...
    • Age-related macular degeneration in the aspect of chronic low-grade inflammation (Pathophysiological ParaInflammation) 

      Nita, Małgorzata; Grzybowski, Andrzej; Ascaso, Francisco J.; Huerva, Valentín (Hindawi Publishing Corporation, 2014)
      The products of oxidative stress trigger chronic low-grade inflammation (pathophysiological parainflammation) process in AMD patients. In early AMD, soft drusen contain many mediators of chronic low-grade inflammation such ...
    • Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue 

      Villarroya, Joan; Villarroya, Francesc; Gallego-Escuredo, José M.; Delgado‐Anglés, Alejando; Cairó, Montserrat; Moure, Ricardo; Mateo, Gracia M.; Domingo, Joan C.; Domingo, Pere; Giralt, Marta (Wiley Open Access, 2018)
      Fibroblast growth factor 21 (FGF21) has been proposed to be an antiaging hormone on the basis of experimental studies in rodent models. However, circulating FGF21 levels are increased with aging in rodents and humans. ...
    • AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia 

      Yang, Shuai; Zhao, Xinmei; Xu, Hui; Chen, Fan; Xu, Yitao; Li, Zhe; Sanchis, Daniel; Jin, Liang; Zhang, Yubin; Ye, Junmei (MDPI, 2017)
      The AKT (protein kinase B, PKB) family has been shown to participate in diverse cellular processes, including apoptosis. Previous studies demonstrated that protein kinase B2 (AKT2 − / − ) mice heart was sensitized to ...
    • Alopecias cicatriciales 

      Abal Diaz, Leandro; Soria, Xavier; Casanova i Seuma, Josep M. (Josep Manel) (Elsevier, 2012)
      Las alopecias cicatriciales constituyen un grupo de trastornos que dan lugar a una pérdida permanente de cabello como consecuencia de diversos procesos. En este artículo nos centraremos en las alopecias cicatriciales ...
    • El alta voluntaria y la fuga en los servicios de urgencias: un reto con implicaciones éticas y médico-legales 

      Yuguero Torres, Oriol; Pérez Pérez, Rosa María (Sociedad Española de Medicina de Urgencias y Emergencias (SEMES), 2018)
    • Alterations in one-carbon metabolism in celiac disease 

      Martin-Masot, Rafael; Mota Martorell, Natàlia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
      Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
    • Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy 

      Ruiz, Montserrat; Jové Font, Mariona; Schlüter, Agatha; Casasnovas, Carlos; Villarroya, Francesc; Guilera, Cristina; Ortega, Francisco J.; Naudí i Farré, Alba; Pamplona Gras, Reinald; Gimeno, Ramón; Fourcade, Stéphane; Portero Otín, Manuel; Pujol, Aurora (Oxford University Press, 2015)
      X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ...
    • Altered intracellular calcium homeostasis and endoplasmic reticulum redox state in Saccharomyces cerevisiae cells lacking Grx6 glutaredoxin 

      Puigpinós Roig, Judit; Casas Herranz, Celia; Herrero Perpiñán, Enrique (American Society for Cell Biology, 2015)
      Glutaredoxin 6 (Grx6) of Saccharomyces cerevisiae is an integral thiol oxidoreductase protein of the endoplasmic reticulum/Golgi vesicles. Its absence alters the redox equilibrium of the reticulum lumen toward a more ...
    • Ambulatory monitoring in the diagnosis and management of obstructive sleep apnoea syndrome 

      Corral-Peñafiel, Jaime; Pepin, Jean-Louis; Barbé Illa, Ferran (European Respiratory Society, 2013)
      Obstructive sleep apnoea (OSA) is a highly prevalent disorder associated with complications such as arterial hypertension, cardiovascular diseases and traffic accidents. The resources allocated for OSA are insufficient ...
    • Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst 

      Sangalli-Leite, Fernanda; Scorzoni, Liliana; Mesa-Arango, Ana Cecilia; Casas Herranz, Celia; Herrero Perpiñán, Enrique; Mendes Gianinni, Maria José Soares; Rodríguez-Tudela, Juan Luis; Cuenca-Estrella, Manuel; Zaragoza, Oscar (Elsevier, 2011)
      We studied the effects of Amphotericin B (AmB) on Cryptococcus neoformans using different viability methods (CFUs enumeration, XTT assay and propidium iodide permeability). After 1 h of incubation, there were no viable ...
    • An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain 

      Arrospide, Arantzazu; Forné Izquierdo, Carles; Rué i Monné, Montserrat; Torà, Núria; Mar, Javier; Baré, Marisa (BioMed Central, 2013)
      Background: The aim of this study was to evaluate the calibration and discriminatory power of three predictive models of breast cancer risk. Methods: We included 13,760 women who were first-time participants in the ...
    • An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death 

      Garcia-Belinchón, Mercè; Sánchez-Osuna, María; Martínez-Escardó, Laura; Granados-Colomina, Carla; Pascual-Guiral, Sònia; Iglesias-Guimarais, Victoria; Casanelles, Elisenda; Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José) (American Society for Biochemistry and Molecular Biology, 2015)
      Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling of ...
    • An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation 

      Bai, Chao; Rivera Vélez, Sol Maiam; Medina Piles, Vicente; Alves, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Canela i Garayoa, Ramon; Capell Capell, Teresa; Sandmann, Gerhard; Christou, Paul; Zhu, Changfu (Wiley, 2014)
      We have developed an assay based on rice embryogenic callus for rapid functional characterization of metabolic genes. We validated the assay using a selection of well-characterized genes with known functions in the carotenoid ...
    • An inducible knockout mouse to model the cellautonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias 

      Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Dosil, Maria Alba; Santacana Espasa, Maria; Pallares, Judit; Gatius Calderó, Sònia; Bergadà Bertran, Laura; Maiques Carlos, Oscar; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Company of Biologists, 2013)
      PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple ...