Now showing items 28-47 of 906

    • A TrkB/EphrinA Interaction Controls Retinal Axon Branching and Synaptogenesis 

      Marler, Katharine J. M.; Becker-Barroso, Elena; Martínez, Albert; Llovera i Tomàs, Marta; Wentzel, Corinna; Poopalasundaram, Subathra; Hindges, Robert; Soriano, Eduardo; Comella i Carnicé, Joan Xavier; Drescher, Uwe (Society for Neuroscience, 2008)
      Toward understanding topographically specific branching of retinal axons in their target area, we have studied the interaction between neurotrophin receptors and members of the Eph family. TrkB and its ligand BDNF are ...
    • Abdominal tuberculosis mimicking Crohn’s disease’s exacerbation: a clinical, diagnostic and surgical dilemma. A case report 

      Papis, Davide; Branchi, Vittorio; Gómez Quiles, Luis; Herrerias, Fernando; Vilardell, Felip; Gonzalez, Marta; Olsina Kissler, Jorge Juan (Elsevier, 2015)
      INTRODUCTION: Tuberculosis in Europe is a health public problem, which has increased constantly over the last few decades. The most common clinical manifestation of tuberculosis is pulmonary. The diagnosis of extrapulmonary ...
    • Aberrant regulation of the GSK-3b/NRF2 axis unveils a novel therapy for adrenoleukodystrophy 

      Ranea-Robles, Pablo; Launay, Nathalie; Ruiz, Montserrat; Calingasan, Noel Ylagan; Dumont, Magali; Naudí i Farré, Alba; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre; Beal, M. Flint; Fourcade, Stéphane; Pujol, Aurora (Wiley Open Access, 2018)
      The nuclear factor erythroid 2-like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early-appearing feature in X-linked adrenoleukodystrophy (X-ALD) patients and ...
    • Ability and non-ability traits in chess skill 

      Blanch Plana, Angel; Llaveria, Anton (Elsevier, 2021-04-05)
      Chess is an appropriate model to study ability and non-ability traits as related with performance because it bears intellectual and emotional demanding requirements. With a group of amateur chess players (n = 100), the ...
    • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease 

      Gomez Pastor, Rocio; Burchfiel, Eileen T.; Neef, Daniel W.; Jaeger, Alex M.; Cabiscol Català, Elisa; McKinstry, Spencer U.; Doss, Argenia; Aballay, Alejandro; Lo, Donald C.; Akimov, Sergey S.; Ross, Christopher A.; Eroglu, Cagla; Thiele, Dennis J. (Nature, 2017)
      Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery ...
    • Absence of substantial copy number differences in a pair of monozygotic twins discordant for features of autism spectrum disorder 

      Laplana Lafaja, Marina; Royo Sánchez-Palencia, José Luis; Aluja Fabregat, Antón; López, Ricard; Heine-Suñer, Damià; Fibla Palazón, Joan (Hindawi Publishing Corporation, 2014)
      Autism spectrum disorder (ASD) is a highly heritable disease (∼0.9) with a complex genetic etiology. It is initially characterized by altered cognitive ability which commonly includes impaired language and communication ...
    • Access and utilization of social and health services as a social determinant of health: The case of undocumented Latin American immigrant women working in Lleida (Catalonia, Spain) 

      Gea Sánchez, Montserrat; Gastaldo, Denise; Molina, Fidel; Otero García, Laura (John Wiley & Sons Ltd, 2015)
      Although Spain has social and healthcare systems based on universal coverage, little is known about how undocumented immigrant women access and utilise them. This is particularly true in the case of Latin Americans who are ...
    • Access to and use of sexual and reproductive health services provided by midwives among rural immigrant women in Spain: midwives’ perspectives 

      Otero García, Laura; Goicolea, Isabel; Gea Sánchez, Montserrat; Sanz-Barbero, Belen (Co-Action Publishing, 2013)
      Background: There is insufficient information regarding access and participation of immigrant women in Spain in sexual and reproductive health programs. Recent studies show their lower participation rate in gynecological ...
    • Accumulation of misfolded SOD1 in dorsal root ganglion degenerating propioceptive sensory neurons of transgenic mice with amyotrophic lateral sclerosis 

      Sábado, Javier; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Hindawi Publishing Corporation, 2014)
      Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease affecting upper and lower motoneurons (MNs). Although the motor phenotype is a hallmark for ALS, there is increasing evidence that ...
    • Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA 

      Narcís, Oriol J.; Tapia, Olga; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Nature Research, 2018)
      Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective ...
    • Acetylsalicylic acid prevents intermittent hypoxia-induced vascular remodeling in a murine model of sleep apnea 

      Suarez-Giron, Monique C.; Castro-Grattoni, Anabel L.; Torres, Marta; Farré, Ramon; Barbé Illa, Ferran; Sánchez de la Torre, Manuel; Gozal, David; Picado, Cesar; Montserrat i Capdevila, Josep; Almendros, Isaac (Frontiers Media, 2018)
      Study objectives: Chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA), induces accelerated atherogenesis as well as aorta vascular remodeling. Although the cyclooxygenase (COX) pathway ...
    • Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy 

      Morató, Laia; Ruiz, M.; Boada Pallàs, Jordi; Calingasan, Noel Ylagan; Galino, Jorge; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Serrano, M.; Portero Otín, Manuel; Beal, M. F.; Fourcade, Stéphane; Pujol, Aurora (Macmillan Publishers, 2015)
      Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the ...
    • Actualización de la depresión postictus: nuevos retos en pacientes con ictus minor o ataque isquémico transitorio 

      Carnes Vendrell, Anna; Deus Yela, Juan; Molina Seguin, Jessica; Pifarré Paredero, Josep; Purroy Garcia, Francisco (Viguera Editores, 2016)
      Introducción. El ictus es una de las principales causas de discapacidad en la población adulta. El desarrollo de síntomas depresivos es la complicación afectiva más frecuente. Hasta ahora, en la mayoría de los estudios ...
    • Adaptation and Validation of the Diabetic Foot Ulcer Scale-Short Form in Spanish Subjects 

      Martínez González, María Dolores; Dòria, Montserrat; Martínez Alonso, Montserrat; Alcubierre Calvo, Núria; Valls, Joan; Verdú-Soriano, José; Granado Casas, Minerva; Mauricio Puente, Dídac (MDPI, 2020)
      Diabetic foot ulcer (DFU) is a chronic complication that negatively affects the quality of life (QoL) of diabetic patients. In Spain, there is no specifically designed and validated instrument to assess the QoL of patients ...
    • Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential 

      Serrano Casasola, José Carlos Enrique; Baena-Fustegueras, Juan A; Martín Garí, Meritxell; Rassendren, Helene; Cassanyé, Anna; Naudí i Farré, Alba; López Cano, Carolina; Sánchez Peña, Enric; Fuente Juárez, Mari Cruz de la; Herrería González, Fernando; Olsina Kissler, Jorge Juan; Lecube Torelló, Albert; Portero Otín, Manuel (Wiley online library, 2019-05)
      Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ...
    • Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence 

      Moreno-Navarrete, José María; Liñares-Pose, Laura; Sabater, Mónica; Rial-Pensado, Eva; Comas, Ferran; Jové Font, Mariona; Latorre, Jèsica; Ortega Delgado, Francisco José; Ricart, Wifredo; Portero Otín, Manuel; López, Miguel; Fernández Real, José Manuel (Karger Publishers Open Access, 2018-11-18)
      Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ...
    • Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium 

      Chang, Alex R.; Grams, Morgan E.; Ballew, Shoshana H.; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M.; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J.; Li, Yuanying; Navaneethan, Sankar D.; Roderick, Paul J; Valdivielso Revilla, José Manuel; Visseren, Frank L. J.; Zhang, Luxia; Gansevoort, Ron T.; Hallan, Stein I.; Levey, Andrew S.; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark (BMJ Publishing Group, 2019)
      OBJECTIVE To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality. DESIGN ...
    • Advanced lipoprotein profle disturbances in type 1 diabetes mellitus: a focus on LDL particles 

      Amor, Antonio J.; Castelblanco Echavarría, Esmeralda; Hernández, Marta; Gimenez, Marga; Granado Casas, Minerva; Blanco, Jesús; Soldevila, Berta; Esmatjes, Enric; Conget, Ignacio; Alonso, Núria; Ortega, Emilio; Mauricio Puente, Dídac (BioMed Central, 2020)
      Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profle in T1DM individuals, and analysed ...
    • Adverse effects of a SOD1-peptide immunotherapy on SOD1(G93A) mouse slow model of amyotrophic lateral sclerosi 

      Sábado, J.; Casanovas i Llorens, Anna; Rodrigo, H.; Arqué, G.; Esquerda Colell, Josep (Elsevier, 2015-12-01)
      Previous reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). ...
    • Age-related macular degeneration in the aspect of chronic low-grade inflammation (Pathophysiological ParaInflammation) 

      Nita, Małgorzata; Grzybowski, Andrzej; Ascaso, Francisco J.; Huerva, Valentín (Hindawi Publishing Corporation, 2014)
      The products of oxidative stress trigger chronic low-grade inflammation (pathophysiological parainflammation) process in AMD patients. In early AMD, soft drusen contain many mediators of chronic low-grade inflammation such ...