Browsing Articles publicats (IRBLleida) by Title
Now showing items 155-174 of 1060
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Cardiac troponin values in patients with acute coronary syndrome and sleep apnea: a pilot study
(Elsevier, 2018)Background: An analysis of cardiac injury markers in patients with OSA who sustain an episode of acute coronary syndrome (ACS) may contribute to a better understanding of the interactions and impact of OSA in subjects with ... -
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin.
(Elsevier, 2018-03-01)The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the ... -
Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
(BMC, 2021)Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence ... -
Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis
(John Wiley & Sons; Wiley-Blackwell, 2015)Carotenoids are health-promoting organic molecules that act as antioxidants and essential nutrients. We show that chickens raised on a diet enriched with an engineered corn variety containing very high levels of four key ... -
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
(Elsevier, 2005)Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma ... -
Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton
(Ferrata Storti Foundation, 2009)Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ... -
Catalan and Hungarian Validation of the Zuckerman- Kuhlman-Aluja Personality Questionnaire (ZKA-PQ)
(Universidad Complutense de Madrid and Colegio Oficial de Psicólogos de Madrid; Cambridge University Press, 2014)The goal of this study was to examine the cross-cultural validity and reliability of the Zuckerman-Kuhlman- Aluja Personality Questionnaire (ZKA-PQ) – a recently published instrument for assessing the Zuckerman’s ... -
CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model
(Frontiers, 2021-02-10)Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ... -
Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX
(Elsevier, 2014)PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ... -
Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage
(Frontiers Media, 2020-10-15)Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. ... -
Cell differentiation, caspase inhibition and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two cdk inhibitory drugs.
(Elsevier, 2004)Olomoucine and Roscovitine are two ATP-competing compounds described as specific inhibitors of cyclin-dependent kinases (CDK). Both drugs showed to induce apoptosis in SH-SY5Y, a neuroblastoma-derived cell line. In these ... -
Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment
(MDPI, 2021)Previous evidence links the formation of extranuclear inclusions of transcription factors, such as ERK, Jun, TDP-43, and REST, with oxidative, endoplasmic-reticulum, proteasomal, and osmotic stress. To further characterize ... -
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus
(Elsevier, 2017)Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ... -
Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress
(Hindawi Publishing Corporation, 2012)Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron ... -
Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome
(Public Library of Science, 2016)Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ... -
Characterisation of the inflammatory response triggered by topical ingenol mebutate 0.05% gel in basal cell carcinoma
(Wiley; Australasian College of Dermatologists, 2020-01-16)Background/Objective Ingenol mebutate gel is approved for actinic keratosis field therapy, but little has been published as a treatment of basal cell carcinoma (BCC). Our objective is to characterise the histopathological ... -
Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project
(BioMed Central, 2019-11-15)BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ... -
Characteristics of hospitalized cases of Pertussis in Catalonia and Navarra, two regions in the north of Spain
(Public Library of Science, 2015)Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis ... -
Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity
(Elsevier, 2003)After screening a Candida albicans genome database the product of an open reading frame (ORF) (CA2880) with 49% homology to the product of Saccharomyces cerevisiae YPL133c, a putative transcriptional factor, was identified. ... -
Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer
(Impact Journals, 2016)Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...