Now showing items 139-158 of 906

    • Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton 

      Barbier, Sardine; Chatre, Laurent; Bras, Marlène; Sancho, Patricia; Roué, Gaël; Virely, Clémence; Yuste Mateos, Víctor J. (Víctor José); Baudet, Sylvie; Rubio, Manuel; Esquerda Colell, Josep; Sarfati, Marika; Merle-Béral, Hélène; Susin, Santos A. (Ferrata Storti Foundation, 2009)
      Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ...
    • Catalan and Hungarian Validation of the Zuckerman- Kuhlman-Aluja Personality Questionnaire (ZKA-PQ) 

      Surányi, Zsuzsanna; Aluja Fabregat, Antón (Universidad Complutense de Madrid and Colegio Oficial de Psicólogos de MadridCambridge University Press, 2014)
      The goal of this study was to examine the cross-cultural validity and reliability of the Zuckerman-Kuhlman- Aluja Personality Questionnaire (ZKA-PQ) – a recently published instrument for assessing the Zuckerman’s ...
    • CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model 

      Sala Solé, Ester; Vived Maza, Celia; Luna Salinas, Júlia; Saavedra Ávila, Noemí Alejandra; Sengupta, Upasana; Castaño, A. Raúl; Villar-Pazos, Sabrina; Haba, Laura; Verdaguer Autonell, Joan; Ropero, Ana Belén; Stratmann, Thomas; Pizarro, Javier; Vázquez-Carrera, Manuel; Nadal, Ángel; Lahti, Jill M.; Mora Giral, Concepció (Frontiers, 2021-02-10)
      Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ...
    • Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX 

      Mattiolo, Paolo; Barbero-Farran A.; Amigó J.; Ripamonti M.; Ribas i Fortuny, Judit; Boix Torras, Jacint (Elsevier, 2014)
      PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ...
    • Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage 

      Chicote, Javier; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Frontiers Media, 2020-10-15)
      Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. ...
    • Cell differentiation, caspase inhibition and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two cdk inhibitory drugs. 

      Ribas i Fortuny, Judit; Boix Torras, Jacint (Elsevier, 2004)
      Olomoucine and Roscovitine are two ATP-competing compounds described as specific inhibitors of cyclin-dependent kinases (CDK). Both drugs showed to induce apoptosis in SH-SY5Y, a neuroblastoma-derived cell line. In these ...
    • Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus 

      Tapia, Olga; Narcís, Oriol J.; Riancho, Javier; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Elsevier, 2017)
      Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ...
    • Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Gonzalo Benito, Hugo; Boada Pallàs, Jordi; Prat Corominas, Joan; Portero Otín, Manuel; Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2012)
      Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron ...
    • Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome 

      Florés, Marina; Batlle Garcia, Jordi de; Sánchez de la Torre, Alicia; Sánchez de la Torre, Manuel; Aldomá, Albina; Worner, Fernando; Galera, Estefanía; Seminario, Asunción; Torres, Gerard; Dalmases, Mireia; Montserrat i Capdevila, Josep; Garmendia, Onintza; Barbé Illa, Ferran (Public Library of Science, 2016)
      Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ...
    • Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project 

      Sánchez Peña, Enric; Betriu i Bars, M. Àngels; López Cano, Carolina; Hernández García, Marta; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Bermúdez López, Marcelino; Farràs-Sallés, Cristina; Barril, Silvia; Pamplona Gras, Reinald; Rius, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (BioMed Central, 2019-11-15)
      BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ...
    • Characteristics of hospitalized cases of Pertussis in Catalonia and Navarra, two regions in the north of Spain 

      Crespo, Inma; Toledo, Diana; Soldevila, Núria; Jordán, Iolanda; Solano, Rubén; Castilla, Jesús; Caylà, Joan A.; Godoy i García, Pere; Muñoz Almagro, Carmen; Domínguez García, Àngela (Public Library of Science, 2015)
      Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis ...
    • Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity 

      Moreno, Inmaculada; Pedreño, Yolanda; Maicas i Prieto, Sergio; Sentandreu, Rafael; Herrero Perpiñán, Enrique; Valentín, Eulogio (Elsevier, 2003)
      After screening a Candida albicans genome database the product of an open reading frame (ORF) (CA2880) with 49% homology to the product of Saccharomyces cerevisiae YPL133c, a putative transcriptional factor, was identified. ...
    • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

      Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández-Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarres, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
      Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
    • Characterization of sleep breathing pattern in patients with type 2 diabetes: sweet sleep study 

      Lecube Torelló, Albert; Sampol, Gabriel; Hernández, Cristina; Romero, Odile; Ciudin, Andreea; Simó, Rafael (Public Library of Science, 2015)
      Background: Although sleep apnea-hypopnea syndrome (SAHS) is highly prevalent in patients with type 2 diabetes (T2D), it is unknown whether or not subjects with and without T2D share the same sleep breathing pattern. ...
    • Characterization of the Cell Death Process Induced by Staurosporine in Human Neuroblastoma Cell Lines 

      Boix Torras, Jacint; Llecha Cano, Núria; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Elsevier, 1997)
      Staurosporine is a potent and non-specific inhibitor of protein kinases. There is also evidence of staurosporine being a potent inducer of apoptosis. In several human neuroblastoma cell lines (SH-SY5Y, NB69, IMR-5 and ...
    • Characterization of the CPAP-treated patient population in Catalonia 

      Turino, Cecilia; Bertran, Sandra; Gavaldá, Ricard; Teixidó Torrelles, Ivan; Woehrle, Holger; Rué i Monné, Montserrat; Solsona Tehàs, Francesc; Escarrabill, Joan; Colls, Cristina; García-Altés, Anna; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Public Library of Science, 2017)
      There are different phenotypes of obstructive sleep apnoea (OSA), many of which have not been characterised. Identification of these different phenotypes is important in defining prognosis and guiding the therapeutic ...
    • Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage 

      Serrano Casasola, José Carlos Enrique; Martín Garí, Meritxell; Cassanyé, Anna; Granado-Serrano, Ana Belén; Portero Otín, Manuel (Public Library of Science, 2017)
      Soybean is recognized as rich source of bioactive compounds for the improvement of glucose homeostasis. However, the post-prandial mechanisms of action have not been extensively described. The aim of this study is to ...
    • Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma 

      Sanegre, Sabina; Eritja Sánchez, Núria; De Andrea, Carlos; Diaz-Martin, Juan; Diaz-Lagares, Ángel; Jácome, María Amalia; Salguero-Aranda, Carmen; García Ros, David; Davidson, Ben; Lopez, Rafel; Melero, Ignacio; Navarro, Samuel; Ramon y Cajal, Santiago; Alava, Enrique de; Matias-Guiu, Xavier; Noguera, Rosa (Frontiers Media, 2021)
      The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular ...
    • Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Camats, Judith; David, Mónica Delia; Benguria, Alberto; Dopazo, Ana; Cantí Nicolás, Carles; Herreros Danés, Judit (Frontiers, 2013)
      Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that ...
    • Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS 

      Rando, Amaya; Torre, Miriam de la; Martinez-Muriana, Anna; Zaragoza, Pilar; Musaro, Antonio; Hernández i Estanyol, Sara; Navarro, X. (Xavier); Toivonen, Janne M.; Osta, Rosario (Public Library of Science, 2019)
      Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ...