Now showing items 131-150 of 956

    • Calidad de vida global en personas con demencia 

      Lucas Carrasco, Ramona; Peró, Maribel; March Llanes, Jaume (Viguera Editores, 2011)
      Evaluar la calidad de vida (CV) global en personas con demencia e investigar las variables asociadas con la percepción subjetiva de la CV.
    • Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice 

      Jové Font, Mariona; Naudí i Farré, Alba; Ramírez-Núñez, Omar; Portero Otín, Manuel; Selman, Colin; Withers, Dominic J.; Pamplona Gras, Reinald (John Wiley & SonsAnatomical Society, 2014-10-01)
      Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects ...
    • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

      Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2014)
      Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
    • Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice 

      Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Periyakaruppiah, Ambika; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Verlag, 2018)
      Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ...
    • Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models 

      Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Hidalgo, Iván; Vivancos, Nuria; Romero-Guevara, Ricardo; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Nature, 2020-06-25)
      Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration of spinal cord motoneurons (MNs), progressive skeletal ...
    • Can eukaryotic cells monitor the presence of unreplicated DNA? 

      Torres Rosell, Jordi; Piccoli, Giacomo De; Aragón, Luis (BioMed Central, 2007)
      Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle ...
    • Capecitabine and bevacizumab as first-line treatment in elderly patients with metastatic colorectal cancer 

      Feliu, Jaime; Safont, M. J.; Salud Salvia, Maria Antonieta; Losa, F.; García-Girón, C.; Bosch, Carlos; Escudero, P.; López, R.; Madroñal, C.; Bolaños, M.; Gil, M.; Llombart, A.; Castro-Carpeño, J.; González-Barón, M. (Nature Publishing GroupCancer Research UK, 2010)
      BACKGROUND: The efficacy and safety of capecitabine and bevacizumab in elderly patients with metastatic colorectal cancer (mCRC) considered unsuitable for receiving first-line chemotherapy with an irinotecan or oxaliplatin-based ...
    • Capecitabine and irinotecan with bevacizumab 2-weekly for metastatic colorectal cancer: the phase II AVAXIRI study 

      Garcia-Alfonso, Pilar; Chaves, Manuel; Muñoz, Andrés; Salud Salvia, Maria Antonieta; García-Gonzalez, Maria; Grávalos, Cristina; Massuti, Bartomeu; González-Flores, Encarna; Queralt, Bernardo; López-Ladrón, Amelia; Losa, F.; Gómez, Maria Jose; Oltra, Amparo; Aranda, Enrique (BioMed Central, 2015)
      Background: The optimal sequence of chemotherapeutic agents is not firmly established for the treatment of metastatic colorectal cancer (mCRC). This phase II multi-centre study investigated the efficacy and tolerability ...
    • Características de los casos graves hospitalizados por gripe pandémica A (H1N1) 2009 en Cataluña 

      Godoy i García, Pere; Rodés, Anna; Alvarez, Josep; Camps, Neus; Barrabeig i Fabregat, Irene; Sala, Maria Rosa; Minguell, Sofia; Lafuente, Sarah; Pumarola, Tomás; Domínguez García, Àngela; Plasència, Antoni; CIBERESP Cases and Controls in Pandemic Influenza Working Group (Ministerio de Sanidad y Consumo, 2011)
      Fundamentos. Las pandemias de gripe pueden comportar una mayor gravedad. El objetivo fue determinar las características de los casos graves hospitalizados de gripe pandémica en Cataluña y estudiar factores de riesgo de ...
    • Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway 

      Beà Tàrrega, Aida; García Valero, Juan; Irazoki, Andrea; Lana, Carlos; López-Lluch, Guillermo; Portero Otín, Manuel; Pérez Galán, Patricia; Inserte Igual, Javier; Ruiz Meana, Marisol; Zorzano, Antonio; Llovera i Tomàs, Marta; Sanchis, Daniel (John Wiley & Sons, 2021)
      Cardiovascular diseases are the leading cause of death globally and more than four out of five cases are due to ischemic events. Cardiac fibroblasts (CF) contribute to normal heart development and function, and produce the ...
    • Cardiac troponin values in patients with acute coronary syndrome and sleep apnea: a pilot study 

      Sánchez de la Torre, Alicia; Soler, Xavier; Barbé Illa, Ferran; Florés, Marina; Maisel, Alan; Malhotra, Atul; Rué i Monné, Montserrat; Bertran, Sandra; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Lee, Chi-Hang; Turino, Cecilia; Galera, Estefanía; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel (Elsevier, 2018)
      Background: An analysis of cardiac injury markers in patients with OSA who sustain an episode of acute coronary syndrome (ACS) may contribute to a better understanding of the interactions and impact of OSA in subjects with ...
    • Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin. 

      Blasco Angulo, Natividad; Cámara, Yolanda; Núñez, Estefanía; Beà Tàrrega, Aida; Barés Junqué, Gisel; Forné Izquierdo, Carles; Ruiz Meana, Marisol; Girón, Cristina; Barba, Ignasi; García Arumí, Elena; García Dorado, David; Vázquez, Jesús; Martí, Ramón; Llovera i Tomàs, Marta; Sanchis, Daniel (Elsevier, 2018-03-01)
      The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the ...
    • Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease 

      Gorriz, Jose L.; Arroyo, David; D’Marco, Luis; Torra, Roser; Tomás, Patricia; Puchades, María Jesús; Panizo, Nayara; Pantoja, Jonay; Montomoli, Marco; Llisterri, José Luis; Pallares Carratalá, Vicente; Valdivielso Revilla, José Manuel (BMC, 2021)
      Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence ...
    • Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis 

      Nogareda, Carmina; Moreno, José A.; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (John Wiley & SonsWiley-Blackwell, 2015)
      Carotenoids are health-promoting organic molecules that act as antioxidants and essential nutrients. We show that chickens raised on a diet enriched with an engineered corn variety containing very high levels of four key ...
    • Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs 

      Ribas i Fortuny, Judit; Gómez Arbonés, Javier; Boix Torras, Jacint (Elsevier, 2005)
      Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma ...
    • Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton 

      Barbier, Sardine; Chatre, Laurent; Bras, Marlène; Sancho, Patricia; Roué, Gaël; Virely, Clémence; Yuste Mateos, Víctor J. (Víctor José); Baudet, Sylvie; Rubio, Manuel; Esquerda Colell, Josep; Sarfati, Marika; Merle-Béral, Hélène; Susin, Santos A. (Ferrata Storti Foundation, 2009)
      Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ...
    • Catalan and Hungarian Validation of the Zuckerman- Kuhlman-Aluja Personality Questionnaire (ZKA-PQ) 

      Surányi, Zsuzsanna; Aluja Fabregat, Antón (Universidad Complutense de Madrid and Colegio Oficial de Psicólogos de MadridCambridge University Press, 2014)
      The goal of this study was to examine the cross-cultural validity and reliability of the Zuckerman-Kuhlman- Aluja Personality Questionnaire (ZKA-PQ) – a recently published instrument for assessing the Zuckerman’s ...
    • CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model 

      Sala Solé, Ester; Vived Maza, Celia; Luna Salinas, Júlia; Saavedra Ávila, Noemí Alejandra; Sengupta, Upasana; Castaño, A. Raúl; Villar-Pazos, Sabrina; Haba, Laura; Verdaguer Autonell, Joan; Ropero, Ana Belén; Stratmann, Thomas; Pizarro, Javier; Vázquez-Carrera, Manuel; Nadal, Ángel; Lahti, Jill M.; Mora Giral, Concepció (Frontiers, 2021-02-10)
      Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ...
    • Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX 

      Mattiolo, Paolo; Barbero-Farran A.; Amigó J.; Ripamonti M.; Ribas i Fortuny, Judit; Boix Torras, Jacint (Elsevier, 2014)
      PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ...
    • Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage 

      Chicote, Javier; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Frontiers Media, 2020-10-15)
      Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. ...