Now showing items 115-134 of 1060

    • Biblio-MetReS for user-friendly mining of genes and biological processes in scientific documents 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Alves, Rui; Solsona Tehàs, Francesc (PeerJ, 2014)
      One way to initiate the reconstruction of molecular circuits is by using automated text-mining techniques. Developing more efficient methods for such reconstruction is a topic of active research, and those methods are ...
    • Biblio-MetReS: A bibliometric network reconstruction application and server 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Valls Marsal, Joan; Faus i Torà, Xavier; Alves, Rui; Solsona Tehàs, Francesc (BioMed Central, 2011)
      Background: Reconstruction of genes and/or protein networks from automated analysis of the literature is one of the current targets of text mining in biomedical research. Some user-friendly tools already perform this ...
    • Bin-CE: A comprehensive web application to decide upon the best set of outcomes to be combined in a binary composite endpoint 

      Marsal Mora, Josep Ramon; Ferreira-González, Ignacio; Ribera, Aida; Oristrell, Gerard; Pijoan, Jose Ignacio; García-Dorado, David (Public Library of Science, 2018)
      The estimation of the Sample Size Requirement (SSR) when using a binary composite endpoint (i.e. two or more outcomes combined in a unique primary endpoint) is not trivial. Besides information about the rate of events for ...
    • Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin 

      Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2003)
      Grx5 is a yeast mitochondrial protein involved in iron- sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins. No member of this family has been biochemically charac- terized ...
    • Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness 

      Ruiz‑Plazas, Xavier; Rodríguez‑Gallego, Esther; Alves, Marta; Altuna Coy, Antonio; Lozano‑Bartolomé, Javier; Portero Otín, Manuel; García‑Fontgivell, Joan Francesc; Martínez‑González, Salomé; Segarra, José; Chacón, Matilde R. (BMC (part of Springer Nature), 2019)
      Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ...
    • Biofortification of crops with nutrients: factors affecting utilization and storage 

      Díaz Gómez, Joana; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
      Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
    • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

      Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
      X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
    • Biomarkers of aging in Drosophila 

      Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
      Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
    • Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer 

      Alonso-Alconada, Lorena; de la Fuente, Alexandre; Santacana Espasa, Maria; Ferreiros, Alba; Lopez Lopez, Rafael; Matias-Guiu, Xavier; Abal, Miguel (The Company of Biologists, 2020)
      Metastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for ...
    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae 

      Matias, Ana C.; Marinho, H. Susana; Cyrne, Luísa; Herrero Perpiñán, Enrique; Antunes, Fernando (Elsevier, 2011)
      Taking into account published contradictory results concerning the regulation of fatty acid synthase (Fas) by H2O2, we carried out a systematic study where two methods of H2O2 delivery (steady-state and bolus addition) ...
    • Biweekly cetuximab in combination with FOLFOX-4 in the first-line treatment of wild-type KRAS metastatic colorectal cancer: final results of a phase II, open-label, clinical trial (OPTIMIX-ACROSS Study) 

      Fernandez-Plana, Julen; Pericay, Carles; Quintero, Guillermo; Alonso, Vicente; Salud Salvia, Maria Antonieta; Mendez, Miguel; Salgado, Mercedes; Saigi, Eugeni; Cirera, Luis (BMC, 2014)
      Background: This phase II study aims to evaluate the efficacy and safety of biweekly cetuximab in combination with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) as first-line treatment of metastatic wild-type KRAS ...
    • Bodas de plata: 25 años de la primera demostración del efecto directo del fósforo en la célula paratiroidea 

      Bover, Jordi; Trinidad, Pedro; Jarac, Aquiles; Soler Majoral, Jordi; Martín Malo, Alejandro; Torrese, Armando; Frazão, João; Ureña-Torres, Pablo; Dusso Rosso, Adriana; Aranai, Carolt; Graterol, Fredzzia; Romero, Gregorio; Troya, Maribel; Samaniego, Diana; D’Marco, Luis; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira; Arenas, María Dolores; Torregrosai, Vicente; Navarro González, Juan F.; Lloret, María Jesús; Ballarín, José; Boschp, Ricardo J.; Górriz, José L.; Martin de Francisco, Angel Luis; Gutiérrez, Orlando; Ara, Jordi; Felsenfeld, Arnold; Canalejo, Antonio; Almadén, Yolanda (Elsevier, 2022)
      Aunque el fósforo es un elemento indispensable para la vida, en la naturaleza no se encuentra en estado nativo sino combinado en forma de fosfatos inorgánicos (PO43−), con niveles plasmáticos estrechamente regulados que ...
    • Both human and soya bean ferritins highly improve the accumulation of bioavailable iron and contribute to extend the chronological life in budding yeast 

      Pujol Carrión, Núria; González-Alfonso, Alma; Puig, Sergi; Torre Ruiz, M. A. de la (Society for Applied Microbiology; John Wiley & Sons Ltd., 2021)
      Ferritin proteins have an enormous capacity to store iron in cells. In search for the best conditions to accumulate and store bioavailable iron, we made use of a double mutant null for the monothiol glutaredoxins GRX3 and ...
    • BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics 

      Soria, Xavier; Vilardell, Felip; Maiques Carlos, Oscar; Barceló Gómez, Carla; Sisó, Pol; de la Rosa, Inés; Velasco Sánchez, Ana; Cuevas Sánchez, Dolors; Santacana Espasa, Maria; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Rodrigo, Alberto; Macià Armengol, Anna; Martí Laborda, Rosa Ma. (MDPI, 2021)
      Background: Cutaneous melanoma shows high variability regarding clinicopathological presentation, evolution and prognosis. Methods: Next generation sequencing was performed to analyze hotspot mutations in different areas ...
    • Brain structural correlates of emotion recognition in psychopaths 

      Pera Guardiola, Vanessa; Contreras-Rodríguez, Oren; Batalla, Iolanda; Kosson, David; Menchón, José M.; Pifarré Paredero, Josep; Bosque, Javier; Cardoner, N. (Narcís); Soriano-Mas, Carles (Public Library of Science, 2016)
      Individuals with psychopathy present deficits in the recognition of facial emotional expressions. However, the nature and extent of these alterations are not fully understood. Furthermore, available data on the functional ...
    • BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells 

      Grotsky, David A.; González-Suárez, Ignacio; Novell Álvarez, Anna; Neumann, Martin; Yaddanapudi, Sree C.; Croke, Monica; Martínez Alonso, Montserrat; Redwood, Abena B.; Ortega-Martinez, Sylvia; Feng, Zhihui; Lerma, Enrique; Ramon y Cajal, Teresa; Zhang, Junran; Matias-Guiu, Xavier; Dusso Rosso, Adriana; Gonzalo, Susana (The Rockefeller University Press, 2013)
      Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript ...
    • Breakdown in the brain network subserving moral judgment in criminal psychopathy 

      Pujol Salud, Jesús; Batalla, Iolanda; Contreras-Rodríguez, Oren; Harrison, Ben J.; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Real, Eva; Bosa, Laura; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Oxford University Press, 2012)
      Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in normal population, and has suggested the inappropriate network use in criminal psychopathy. We ...
    • Breast cancer incidence and overdiagnosis in Catalonia (Spain) 

      Martínez Alonso, Montserrat; Vilaprinyo Terré, Ester; Marcos-Gragera, Rafael; Rué i Monné, Montserrat (BioMed Central, 2010)
      Introduction: Early detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to ...
    • Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients 

      Molinero, Marta; Benítez, Iván; González, Jessica; Gort Paniello, Clara; Moncusí Moix, Anna; Rodríguez Jara, Fátima; García Hidalgo, María C.; Torres, Gerard; Vengoechea Aragoncillo, José Javier; Gómez Falguera, Silvia; Cabo Gambín, Ramón; Caballero, Jesús; Bermejo Martin, Jesús F.; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; García Gasulla, Dario; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Torres, Antoni; Barbé Illa, Ferran; de Gonzalo Calvo, David (Frontiers Media, 2022)
      Background: The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients ...