Now showing items 111-130 of 933

    • Biomarkers of aging in Drosophila 

      Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
      Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae 

      Matias, Ana C.; Marinho, H. Susana; Cyrne, Luísa; Herrero Perpiñán, Enrique; Antunes, Fernando (Elsevier, 2011)
      Taking into account published contradictory results concerning the regulation of fatty acid synthase (Fas) by H2O2, we carried out a systematic study where two methods of H2O2 delivery (steady-state and bolus addition) ...
    • Biweekly cetuximab in combination with FOLFOX-4 in the first-line treatment of wild-type KRAS metastatic colorectal cancer: final results of a phase II, open-label, clinical trial (OPTIMIX-ACROSS Study) 

      Fernandez-Plana, Julen; Pericay, Carles; Quintero, Guillermo; Alonso, Vicente; Salud Salvia, Maria Antonieta; Mendez, Miguel; Salgado, Mercedes; Saigi, Eugeni; Cirera, Luis (BMC, 2014)
      Background: This phase II study aims to evaluate the efficacy and safety of biweekly cetuximab in combination with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) as first-line treatment of metastatic wild-type KRAS ...
    • Brain structural correlates of emotion recognition in psychopaths 

      Pera Guardiola, Vanessa; Contreras-Rodríguez, Oren; Batalla, Iolanda; Kosson, David; Menchón, José M.; Pifarré Paredero, Josep; Bosque, Javier; Cardoner, N. (Narcís); Soriano-Mas, Carles (Public Library of Science, 2016)
      Individuals with psychopathy present deficits in the recognition of facial emotional expressions. However, the nature and extent of these alterations are not fully understood. Furthermore, available data on the functional ...
    • BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells 

      Grotsky, David A.; González-Suárez, Ignacio; Novell Álvarez, Anna; Neumann, Martin; Yaddanapudi, Sree C.; Croke, Monica; Martínez Alonso, Montserrat; Redwood, Abena B.; Ortega-Martinez, Sylvia; Feng, Zhihui; Lerma, Enrique; Ramon y Cajal, Teresa; Zhang, Junran; Matias-Guiu, Xavier; Dusso Rosso, Adriana; Gonzalo, Susana (The Rockefeller University Press, 2013)
      Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript ...
    • Breakdown in the brain network subserving moral judgment in criminal psychopathy 

      Pujol Salud, Jesús; Batalla, Iolanda; Contreras-Rodríguez, Oren; Harrison, Ben J.; Pera Guardiola, Vanessa; Hernández-Ribas, Rosa; Real, Eva; Bosa, Laura; Soriano-Mas, Carles; Deus Yela, Juan; López-Solà, Marina; Pifarré Paredero, Josep; Menchón, José M.; Cardoner, N. (Narcís) (Oxford University Press, 2012)
      Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in normal population, and has suggested the inappropriate network use in criminal psychopathy. We ...
    • Breast cancer incidence and overdiagnosis in Catalonia (Spain) 

      Martínez Alonso, Montserrat; Vilaprinyo Terré, Ester; Marcos-Gragera, Rafael; Rué i Monné, Montserrat (BioMed Central, 2010)
      Introduction: Early detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to ...
    • Brote de gastroenteritis por el consumo de agua de suministro público causado por Shigella sonnei 

      Godoy i García, Pere; Bartolomé, Rosa; Torres Puig-gros, Joan; Espinet, Lina; Escobar, Amàlia; Nuin Orrio, Carmen; Domínguez, Ángela (Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS)Elsevier, 2011)
      Objetivos: Investigar un brote de gastroenteritis que afectó a la población de València d’Àneu (Lleida). Métodos: Estudio de cohortes sobre el consumo de agua de la red, de agua embotellada y de agua de manantiales. La ...
    • Budget impact analysis of switching to digital mammography in a population-based breast cancer screening program: a discrete event simulation model 

      Comas, Mercè; Arrospide, Arantzazu; Mar, Javier; Sala i Serra, Maria; Vilaprinyo Terré, Ester; Hernández, Cristina; Cots, Francesc; Martínez, Juan; Castells, Xavier (Public Library of Science, 2014)
      Objective: To assess the budgetary impact of switching from screen-film mammography to full-field digital mammography in a population-based breast cancer screening program. Methods: A discrete-event simulation model was ...
    • Burnout and job satisfaction among nurses in three Spanish regions 

      Acea-López, Lorena; Pastor-Bravo, María del Mar; Rubinat, Esther; Bellon, Filip; Blanco Blanco, Joan; Gea Sánchez, Montserrat; Briones Vozmediano, Erica Tula (Wiley, 2021-05-15)
      Aims: To determine the levels of job satisfaction and burnout syndrome and related factors among nurses in three Spanish regions. Background: The nursing profession involves high work stress due to emotional involvement, ...
    • C-reactive protein and other predictors of poor outcome in patients hospitalized with exacerbations of chronic obstructive pulmonary disease 

      Ruiz González, Agustín; Lacasta García, José Daniel; Ibarz Escuer, Mercedes; Martínez Alonso, Montserrat; Falguera i Sacrest, Miquel; Porcel Pérez, José Manuel (Wiley, 2008)
      Background and objective: CRP is elevated in patients with acute exacerbations of COPD (AECOPD), but there is little information on whether this biomarker can help to identify adverse short-term clinical outcomes. Methods: ...
    • Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala 

      Hertel, Nicole; Redies, Christoph; Medina Hernández, Loreta Mª (Wiley, 2012)
      The amygdaloid complex represents a group of telencephalic nuclei and cortical areas that control emotional and social behavior. Amygdalar development is poorly understood. It is generally accepted that the structures of ...
    • Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(II), and Cd–metallothionein complexes 

      Espart Herrero, Anna; Artime, Sebastián; Tort Nasarre, Glòria; Yara Varón, Edinson (Royal Society of Chemistry, 2018)
      Cadmium (Cd) is a non-physiological heavy metal that can be harmful at low concentrations. Increasing anthropogenic activities are incrementing the risk of accumulation of this heavy metal in different organs and tissues ...
    • Calcium channel expression and applicability as targeted therapies in melanoma 

      Macià Armengol, Anna; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Cantí Nicolás, Carles (Hindawi Publishing Corporation, 2015)
      The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ...
    • Calcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetes 

      Ramírez-Morros, Anna; Granado Casas, Minerva; Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Real, Jordi; Castelblanco Echavarría, Esmeralda; Esquerda, Aureli; Cao, Gonzalo; Rubinat, Esther; Hernández, Marta; Alonso, Núria; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (Hindawi Publishing Corporation, 2017)
      Aims. To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined ...
    • Calcium-binding proteins, neuronal nitric oxide synthase, and GABA help to distinguish different pallial areas in the developing and adult chicken. I. Hippocampal formation and hyperpallium 

      Suárez, Juan; Dávila, José Carlos; Real, M. Ángeles; Guirado, Salvador; Medina Hernández, Loreta Mª (Wiley, 2006)
      To better understand the formation and adult organization of the avian pallium, we studied the expression patterns of gamma-aminobutyric acid (GABA), calbindin (CB), calretinin (CR), and neuronal nitric oxide synthase ...
    • Calculation of iris-claw IOL power for correction of late in-the-bag IOL complex dislocation 

      Huerva, Valentín; Ascaso, Francisco J.; Caral, Isabel; Grzybowski, Andrzej (BMC, 2017)
      Background: To assess the constants and formula for aphakia correction with iris-claw IOLs to achieve the best refractive status in cases of late in-the-bag IOL complex dislocation. Methods: A literature search was performed. ...
    • Calidad de vida global en personas con demencia 

      Lucas Carrasco, Ramona; Peró, Maribel; March Llanes, Jaume (Viguera Editores, 2011)
      Evaluar la calidad de vida (CV) global en personas con demencia e investigar las variables asociadas con la percepción subjetiva de la CV.
    • Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice 

      Jové Font, Mariona; Naudí i Farré, Alba; Ramírez-Núñez, Omar; Portero Otín, Manuel; Selman, Colin; Withers, Dominic J.; Pamplona Gras, Reinald (John Wiley & SonsAnatomical Society, 2014-10-01)
      Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects ...