Now showing items 940-959 of 1083

    • T-type Ca2+ Channels: T for Targetable 

      Crespí Sallán, Marta; Visa Pretel, Anna; Shaikh, Soni; Nàger Grifo, Mireia; Herreros Danés, Judit; Cantí Nicolás, Carles (Taylor & Francis, 2018-01-17)
      In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ...
    • T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1 

      Maiques Carlos, Oscar; Barceló Gómez, Carla; Panosa, Anaïs; Pijuan Marquilles, Jordi; Orgaz, Jose L.; Rodríguez Hernández, Irene; Matas Nadal, Clara; Tell, Gemma; Vilella, Ramón; Fabra, Angels; Puig, Susana; Sanz Moreno, Victoria; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (Wiley, 2018)
      Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ...
    • T-Type Calcium Channels: A Potential Novel Target in Melanoma 

      Barceló Gómez, Carla; Sisó, Pol; Maiques Carlos, Oscar; de la Rosa, Inés; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (MDPI, 2020)
      T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential ...
    • T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma 

      Visa Pretel, Anna; Crespí Sallán, Marta; Maiques Carlos, Oscar; Alza, Lía; Talavera, Elisabeth; López Ortega, Ricard; Santacana Espasa, Maria; Herreros Danés, Judit; Cantí Nicolás, Carles (American Association for Cancer Research, 2019)
      T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ...
    • Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes 

      Laplana Lafaja, Marina; Sánchez de la Torre, Manuel; Aguiló, Alicia; Casado, Ignasi; Flores, Miquel; Sánchez-Pellicer, Ramon; Fibla Palazón, Joan (Springer, 2010)
      Longevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by ...
    • Target of rapamycin activation predicts lifespan in fruit flies 

      Scialò, Filippo; Sriram, Ashwin; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Pamplona Gras, Reinald; Sanz, Alberto (Taylor & Francis, 2015-09)
      Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ...
    • Targeting T-type channels in cancer: what is on and what is off? 

      Visa Pretel, Anna; Alza, Lía; Casas Benito, Adrian; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2022)
      Over the last 20 years several studies have demonstrated a pivotal role of T‐type calcium channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers have been reported in vitro and in preclinical ...
    • Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calciuminduced cell death 

      Britti, Elena; Ros Salvador, Joaquim; Esteras, Noemi; Abramov, Andey Y. (Elsevier, 2020-03)
      Aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, Alzheimer’s disease; ...
    • TControl: A mobile app to follow up tobacco-quitting patients 

      Pifarré Montalà, Marc; Carrera Peruga, Adrián; Vilaplana Mayoral, Jordi; Cuadrado, Josep; Solsona, Sara; Abella i Pons, Francesc; Solsona Tehàs, Francesc; Alves, Rui (Elsevier, 2017-04)
      Background and Objective Tobacco smoking is a major risk factor for a wide range of respiratory and circulatory diseases in active and passive smokers. Well-designed campaigns are raising awareness to the problem and an ...
    • Techo de cristal y desigualdades de género en la carrera profesional de las mujeres académicas e investigadoras en ciencias biomédicas 

      Segovia Saiz, Carla; Briones Vozmediano, Erica Tula; Pastells Peiró, Roland; González María, Esther; Gea Sánchez, Montserrat (Elsevier, 2019)
      Objetivo: Identificar, en la literatura científica internacional, los obstáculos y factores potencialmente favorecedores para el avance durante su carrera profesional de las mujeres académicas e investigadoras en ciencias ...
    • Telomeric repeat factor 1 protein levels correlates with telomere length in colorectal cancer 

      Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Sociedad Española de Patología Digestiva; Arán Ediciones, 2012)
      Background: colorectal cancer is the third cancer cause of death in Spain. It is important to investigate new tumoral markers for early diagnosis, disease monitoring and prevention strategies. Telomeres protect the ...
    • Tenosynovitis with rice body formation presenting as a cutaneous abscess 

      Moreno, Sara; Forcada Calvet, Pau; Soria, Xavier; Altemir, Victoria; Gatius Calderó, Sònia; Gil, Mabel; Matias-Guiu, Xavier; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (John Wiley & Sons, 2014)
      A 62-year-old woman with a past medical history of rheumatoid arthritis was referred to the Department of Dermatology because of an enlarging cutaneous lesion on the right thumb which resembled a soft tissue infection. ...
    • Testosterone and disinhibited personality in healthy males 

      Aluja Fabregat, Antón; García Rodríguez, Luis Francisco; García, Oscar; Blanco, Eduardo (Elsevier, 2016-06-15)
      The relationship among testosterone (T), free testosterone (FT), bioavailable testosterone (BT) and personality were studied in a sample of 105 healthy males (26.71±9.68 years old). The possible effects of age and other ...
    • Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling 

      Visa Pretel, Anna; Alza, Lía; Cantí Nicolás, Carles; Herreros Danés, Judit (Elsevier, 2022-04-04)
      Mibefradil and NNC-55-0396, tetralol derivatives with a proven ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth ...
    • TGF-β-Induced transcription sustains amoeboid melanoma migration and dissemination 

      Cantelli, Gaia; Orgaz, Jose L.; Rodríguez Hernández, Irene; Karagiannis, Panagiotis; Maiques Carlos, Oscar; Matias-Guiu, Xavier; Nestle, Frank O.; Martí Laborda, Rosa Ma.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2015)
      Cell migration underlies metastatic dissemination of cancer cells, and fast “amoeboid” migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated ...
    • The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells 

      Martínez-Miguel, Patricia; Valdivielso Revilla, José Manuel; Medrano-Andrés, Diana; Román-García, Pablo; Cano-Peñalver, Jose Luis; Rodríguez-Puyol, Manuel; Rodríguez-Puyol, Diego; López-Ongil, Susana (American Physiological Society, 2014)
      Despite the presence of vitamin D receptor (VDR) in endothelial cells, the effect of vitamin D on endothelial function is unknown. An unbalanced production of vasoactive endothelial factors such as nitric oxide (NO) or ...
    • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
      The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...
    • The AMPK family member Snf1 protects Saccharomyces cerevisiae cells upon glutatione oxidation 

      Pérez Sampietro, María; Casas Herranz, Celia; Herrero Perpiñán, Enrique (Public Library of Science, 2013)
      The AMPK/Snf1 kinase has a central role in carbon metabolism homeostasis in Saccharomyces cerevisiae. In this study, we show that Snf1 activity, which requires phosphorylation of the Thr210 residue, is needed for protection ...
    • The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress 

      Amaral, Nuno; Vendrell, Alexandre; Maier, Michael; Kumar, Arun; Mendoza, Manuel; Funaya, Charlotta; Geli, María Isabel; Idrissi, Fatima-Zahra; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Nature, 2016)
      Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response ...
    • The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins 

      Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Csillag, Andras; Perkel, David J.; Reiner, Anton (Elsevier, 2011)
      The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five ...