Now showing items 574-593 of 903

    • N-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation 

      Purroy Garcia, Francisco; Suárez-Luis, Idalmis; Mauri-Capdevila, Gerard; Cambray Carner, Serafí; Farré, Joan; Sanahuja Montesinos, Jordi; Piñol Ripoll, Gerard; Quilez Martínez, Alejandro; González Mingot, Cristina; Begué Gómez, Robert; Gil, M. Isabel; Fernández i Giráldez, Elvira; Benabdelhak Abbou, Ikram (Wiley, 2014-06-25)
      BACKGROUND AND PURPOSE: The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study ...
    • Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells 

      Green, E. Allison; Wong, F. Susan; Eshima, Koji; Mora Giral, Concepció; Flavell, Richard A. (Rockefeller University Press, 2000)
      Neonatal islet-specific expression of tumor necrosis factor (TNF)-α in nonobese diabetic mice promotes diabetes by provoking islet-infiltrating antigen-presenting cells to present islet peptides to autoreactive T cells. ...
    • Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury 

      Casanovas i Llorens, Anna; Salvany, Sara; Lahoz, Víctor; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Sabater, Raimundo; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Nature, 2017)
      The electric activity of lower motor neurons (MNs) appears to play a role in determining cell-vulnerability in MN diseases. MN excitability is modulated by cholinergic inputs through C-type synaptic boutons, which display ...
    • Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice Correlations With Plaques, Tangles, and Oligomeric Species 

      López González, Irene; Schlüter, Agatha; Aso, Ester; García Esparcia, Paula; Ansoleaga, Belen; Llorens, Franc; Moreno, Jesús; Fuso, Andrea; Portero Otín, Manuel; Pamplona Gras, Reinald; Pujol, Aurora; Ferrer, Isidre; Carmona, Margarita (Oxford Journals, 2015)
      To understand neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease (sAD), we performed functional genomics analysis and analyzed messenger RNA (mRNA) expression by quantitative ...
    • Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV 

      Pérez García, María José; Gou Fàbregas, Myriam; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma. (American Society for Biochemistry and Molecular Biology, 2008)
      Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ...
    • Neuropsychiatric Symptoms and Quality of Life in Spanish Alzheimer's Disease Patients During COVID-19 Lockdown 

      Lara, Beatriz; Carnes, Anna; Dakterzada, Farida; Benitez, Ivan; Piñol Ripoll, Gerard (Wiley, 2020)
      Background and purpose: The COVID epidemic is affecting individuals worldwide, and Alzheimer's disease (AD) and amnesic mild cognitive impairment (MCI) patients are at risk due to their characteristics and age. We analysed ...
    • Neuropsychological profile in bipolar disorder: a preliminary study of monotherapy lithium-treated euthymic bipolar patients evaluated at a 2-year interval 

      Mur, Maria; Portella, Maria J.; Martínez-Aran, A.; Pifarré Paredero, Josep; Vieta i Pascual, Eduard, 1963- (Wiley, 2008)
      Objective: To investigate the cognitive impairment of a sample of euthymic bipolar patients treated with lithium monotherapy at baseline in a 2-year longitudinal study. Method: Fifteen DSM-IV-TR bipolar out-patients and ...
    • Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis 

      Bourne, C.; Aydemir, Ö.; Balanzá Martínez, V.; Bora, E.; Brissos, S.; Cavanagh, J. T. O.; Clark, L.; Cubukcuoglu, Z.; Videira Dias, V.; Dittmann, S.; Ferrier, I. N.; Fleck, D. E.; Frangou, S.; Gallagher, P.; Jones, L.; Kieseppä, T.; Martínez Aran, A.; Melle, I.; Moore, P. B.; Mur, Maria; Pfennig A, Raust A.; Senturk, V.; Simonsen, C.; Smith, D. J.; Bio, D. S.; Soeiro de Souza, M. G.; Stoddart, S. D. R.; Sundet K, Szöke A.; Thompson, J. M.; Torrent, C.; Zalla, T.; Craddock, N.; Andreassen, O. A.; Leboyer, M.; Vieta, E.; Bauer, M.; Worhunsky, P. D.; Tzagarakis, C.; Rogers, R. D.; Geddes, J. R.; Goodwin, G. M. (Wiley, 2013)
      An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study ...
    • Neuroticism is associated with reduced oxygenation levels in the lateral prefrontal cortex following exposure to unpleasant images 

      Balada, Ferran; Lucas, Ignacio; Blanch Plana, Angel; Blanco Calvo, Eduardo; Aluja Fabregat, Antón (Elsevier, 2019)
      The aim of this study was to explore the prefrontal cortex response to emotional salient stimuli in subjects with high scores in Neuroticism (and low in Sensation Seeking) or high scores in Sensation Seeking (and low in ...
    • New electrocardiographic criteria to differentiate acute pericarditis and myocardial infarction 

      Rosselló, Xavier; Wiegerinck, Rob F.; Alguersuari, Joan; Bardají, Alfredo; Worner, Fernando; Sutil, Mario; Ferrero, Andreu; Cinca, Juan (Elsevier, 2014)
      Objective Transmural myocardial ischemia induces changes in QRS complex and QT interval duration but, theoretically, these changes might not occur in acute pericarditis provided that the injury is not transmural. This ...
    • New Metrics to Assess Type 2 Diabetes after Bariatric Surgery: The “Time-Within-Remission Range” 

      de Hollanda, Ana; Lecube Torelló, Albert; Rubio, Miguel Ángel; Sánchez Peña, Enric; Vilarrasa, Núria; Gregorio Oliva, José; Fernández-Soto, María Luisa; Salas-Salvadó, Jordi; Ballesteros-Pomar, María D.; Ciudin, Andreea; Torres, Ferran; Vidal, Concepción; Morales, María José; Valdés, Sergio; Pellitero, Silvia; Miñambres, Inka; Masmiquel, Lluís; Goday, Albert; Suarez, Lorena; Flores, Liliam; Bueno Díez, Marta; Caixàs, Assumpta; Bretón, Irene; Cámara, Rosa; Olbeyra, Romina; Penso, Rona; de la Cruz, María José; Simó-Servat, Andreu; Pereyra-García, Francisca María; López-Mezquita, Elena Teresa; Gils, Anna; Fidilio, Enzamaria; Bandrés, Orosia; Martínez, Ángel; Abuín, Jose; Marques-Pamies, Montserrat; Tuneu, Laura; Arteaga, Magdalena; Castañer, Olga; Goñi, Fernando; Arrizabalaga, Cristina; Botana, Manuel Antonio; Calañas, Alfonso (MDPI, 2020)
      Almost one third of patients do not achieve type 2 diabetes remission after bariatric surgery or are unable to sustain this effect long term. Our objective was to delve further into the dynamic responses of diabetes after ...
    • New perspectives on CKD-induced dyslipidemia 

      Bermúdez López, Marcelino; Arroyo, David; Betriu i Bars, M. Àngels; Masana, Luis; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Taylor & Francis, 2017-08-27)
      Abstract INTRODUCTION: Chronic kidney disease (CKD) is a world-wide health concern associated with a significantly higher cardiovascular morbidity and mortality. One of the principal cardiovascular risk factors is the lipid ...
    • NF-κB signaling pathways: role in nervous system physiology and pathology 

      Tasheva, Stefka Mincheva; Soler i Tatché, Rosa Ma. (Sage, 2013-04)
      Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is ...
    • Night-time symptoms: a forgotten dimension of COPD 

      Agustí, Àlvar; Hedner, J.; Marin, J.M.; Barbé Illa, Ferran; Cazzola, M.; Rennard, S. (European Respiratory Society, 2011)
      Sleep quality is often poor in patients with chronic obstructive pulmonary disease (COPD), but these night-time symptoms are frequently unnoticed by physicians and/or not reported by patients themselves. Therefore, the ...
    • Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxindeficient yeast 

      Alsina Obiols, David; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2018)
      Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in ...
    • Nivel de conocimiento de la enfermedad de Alzheimer en cuidadores y población general 

      Jorge, C.; Cetó, M.; Arias, A.; Blasco, E.; Gil, M. P.; López, R.; Dakterzada, Farida; Purroy Garcia, Francisco; Piñol Ripoll, Gerard (Elsevier, 2019-05-11)
      Introducción El conocimiento de la enfermedad de Alzheimer es fundamental para el diagnóstico precoz y para reducir la sobrecarga del cuidador. El objetivo fue evaluar el grado de conocimiento de la enfermedad de Alzheimer ...
    • Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Pamplona Gras, Reinald (MDPI, 2013)
      Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes ...
    • Non-invasive imaging techniques and assessment of carotid vasa vasorum neovascularization: promises and pitfalls 

      Pereira, Tania; Betriu i Bars, M. Àngels; Alves, Rui (Elsevier, 2018)
      Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization ...
    • Notch signaling pathway is activated in motoneurons of spinal muscular atrophy 

      Cardona-Rossinyol, Andrea; Garcera, Ana; Torres-Benito, Laura; Soler i Tatché, Rosa Ma.; Tabares, Lucía; Lladó, Jerònia; Olmos, Gabriel; Caraballo-Miralles, Víctor (MDPI, 2013)
      Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. Notch signaling is a cell-cell communication ...
    • Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxins 

      Molina Navarro, Maria Micaela; Bellí i Martínez, Gemma; Torre Ruiz, M. A. de la; Rodríguez Manzanaque, Maria Teresa; Herrero Perpiñán, Enrique (The American Society for Biochemistry and Molecular Biology, 2004)
      Glutaredoxins are thiol oxidoreductases that regulate protein redox state. In Saccharomyces cerevisiae, Grx1 and Grx2 are cytosolic dithiol glutaredoxins, whereas Grx3, Grx4, and Grx5 are monothiol glutaredoxins. ...