Now showing items 523-542 of 903

    • Machine learning techniques for mortality prediction in critical traumatic patients: anatomic and physiologic variables from the RETRAUCI study 

      Servià Goixart, Lluís; Montserrat, Neus; Badia Castello, Mariona; Llompart-Pou, Juan Antonio; Barea-Mendoza, Jesús Abelardo; Chico-Fernández, Mario; Sánchez-Casado, Marcelino; Jiménez, José Manuel; Mayor, Dolores María; Trujillano Cabello, Javier (BMC, 2020-10-20)
      Interest in models for calculating the risk of death in traumatic patients admitted to ICUs remains high. These models use variables derived from the deviation of physiological parameters and/or the severity of anatomical ...
    • Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins 

      Irazusta, Verónica Patricia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2008)
      Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ...
    • Malignant pleural effusion: from bench to bedside 

      Psallidas, Ioannis; Kalomenidis, Ioannis; Porcel Pérez, José Manuel; Robinson, Bruce W.; Stathopoulos, Georgios T. (European Respiratory Society, 2016)
      Malignant pleural effusion (MPE) is a common but serious condition that is related with poor quality of life, morbidity and mortality. Its incidence and associated healthcare costs are rising and its management remains ...
    • Managing an online survey about influenza vaccination in primary healthcare workers 

      Toledo, Diana; Aerny, Nicole; Soldevila, Núria; Baricot, Maretva; Godoy i García, Pere; Castilla, Jesús; García-Gutiérrez, Susana; Torner Gràcia, Núria; Astray, Jenaro; Mayoral, José María; Tamames, Sonia; González-Candelas, Fernando; Martín, Vicente; Díaz, José; Domínguez García, Àngela (MDPI, 2015)
      Online surveys are increasingly used due to their speed and efficiency. The aim of this study was to analyze factors that may have contributed to the quality and speed of response of an online survey on influenza vaccination ...
    • Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms 

      Bahhir, Diana; Yalgin, Cagri; Ots, Liina; Järvinen, Sampsa; George, Jack; Naudí i Farré, Alba; Krama, Tatjana; Krams, Indrikis; Tamm, Mairi; Andjelković, Ana; Dufour, Eric; González de Cosar, Jose M.; Gerards, Mike; Parhiala, Mikael; Pamplona Gras, Reinald; Jacobs, Howard T.; Jõers, Priit (Public Library of Science, 2019-10-04)
      Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ...
    • Más allá de los parámetros lipídicos tradicionales en la enfermedad renal crónica 

      Bermúdez López, Marcelino; Betriu i Bars, M. Àngels; Valdivielso Revilla, José Manuel; Bretones del Pino, Teresa; Arroyo, David; Fernández i Giráldez, Elvira (Elsevier, 2018)
    • Measuring health-related quality of life in men with osteoporosis or osteoporotic fracture 

      Zwart, Marta; Azagra, Rafael; Encabo, Gloria; Aguyé, Amada; Roca, Genís; Güell, Sílvia; Puchol, Núria; Gene, Emili; López-Expósito, Francesc; Solà, Silvia; Ortiz, Sergio; Sancho, Pilar; Abado, Liz; Iglesias, Milagros; Pujol Salud, Jesús; Díez-Pérez, Adolf (BioMed Central, 2011)
      Background: Osteoporosis is a serious health problem that worsens the quality of life and the survival rate of individuals with this disease on account the osteoporotic fractures. Studies have long focused on women, and ...
    • Membrane lipid unsaturation as physiological adaptation to animal longevity 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Frontiers Media, 2013)
      The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and ...
    • Meningococcal disease and vaccines: still many questions and some answers 

      Godoy i García, Pere; Castilla, Jesús; Astray, Jenaro; Tuells, José; Barrabeig, Irene; Domínguez, Ángela (Sociedad Española de Salud Pública y Administración Sanitaria, 2020)
    • Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential 

      Prieto, Ignacio; Rubio Alarcón, Carmen; García-Gómez, Raquel; Berdún Hernández, Rebeca; Urgel, Tamara; Portero Otín, Manuel; Pamplona Gras, Reinald; Martínez-Ruiz, Antonio; Ruiz-Sanz, José Ignacio; Ruiz-Larrea, M. Begoña; Jové Font, Mariona; Cerdán, Sebastián; Monsalve, María (Elsevier, 2020-01-01)
      PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...
    • Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1 

      Moreno Cermeño, Armando J.; Alsina Obiols, David; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Elsevier, 2013)
      Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ...
    • Metabolomic and lipidomic profiling identifies the role of the RNA editing pathway in endometrial carcinogenesis 

      Altadill, Tatiana; Dowdy, Tyrone M.; Gill, Kirandeep; Reques, Armando; Menon, Smrithi S.; Moiola, Cristian P.; Lopez-Gil, Carlos; Coll, Eva; Matias-Guiu, Xavier; Cabrera, Silvia; Garcia, Angel; Reventos, Jaume; W. Byers, Stephen; Gil-Moreno, Antonio; Cheema, Amrita K.; Colás, Eva (Nature Publishing Group, 2017)
      Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
    • Metabolomics predicts stroke recurrence after transient ischemic attack 

      Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)
      Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
    • La metabolómica en el ictus isquémico, nuevos biomarcadores diagnósticos y pronósticos 

      Mauri-Capdevila, Gerard; Jové Font, Mariona; Suárez-Luis, Idalmis; Portero Otín, Manuel; Purroy Garcia, Francisco (Viguera Editores, 2013)
      El estudio de biomarcadores relacionados con el ictus isquémico está adquiriendo una mayor importancia en vistas de conocer mejor los cambios fisiopatológicos de la enfermedad cerebrovascular y facilitar un diagnóstico ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
    • Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women 

      Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Pamplona Gras, Reinald; Victor, Victor M.; Jové Font, Mariona (Nature Publishing Group, 2019-11-05)
      Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ...
    • Method for Improving EEG Based Emotion Recognition by Combining It with Synchronized Biometric and Eye Tracking Technologies in a Non-invasive and Low Cost Way 

      López Gil, Juan Miguel; Virgili Gomà, Jordi; Gil Iranzo, Rosa María; García González, Roberto; Guilera Lladós, Teresa; Batalla, Iolanda; Soler González, Jorge (Frontiers in Computational Neurosciencie, 2016)
      Technical advances, particularly the integration of wearable and embedded sensors, facilitate tracking of physiological responses in a less intrusive way. Currently, there are many devices that allow gathering biometric ...
    • Methods for and results from the study of design principles in molecular systems 

      Salvadó López, Baldiri; Karathia, Hiren; Usié Chimenos, Anabel; Vilaprinyo Terré, Ester; Omholt, Stig; Sorribas Tello, Albert; Alves, Rui (Elsevier, 2011)
      Most aspects of molecular biology can be understood in terms of biological design principles. These principles can be loosely defined as qualitative and quantitative features that emerge in evolution and recur more ...
    • Microangiopathy of common carotid vasa vasorum in type 1 diabetes mellitus 

      Rubinat, Esther; Ortega, Emilio; Traveset Maeso, Alicia; Arcidiacono, Maria V.; Alonso, Núria; Betriu i Bars, M. Àngels; Granado Casas, Minerva; Hernández García, Marta; Soldevila, Jordi; Puig-Domingo, Manuel; Jurjo Campo, Carmen; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (Elsevier, 2015-06-00)
      Objective: We hypothesize that in type 1 diabetes vasa vasorum (VV) are affected by microangiopathic changes. For this purpose, we assessed the status of the VV signal in patients with type 1 diabetes. Methods: The VV ...