Now showing items 500-519 of 1054

    • ICU-Acquired Pneumonia Is Associated with Poor HealthPost-COVID-19 Syndrome 

      Martín Loeches, Ignacio; Motos, Anna; Menéndez, Rosario; Gabarrús, Albert; González, Jessica; Fernández Barat, Laia; Ceccato, Adrián; Pérez Arnal, Raquel; García Gasulla, Dario; Ferrer, Ricard; Riera, Jordi; Lorente, José Ángel; Peñuelas, Oscar; Bermejo Martin, Jesús F.; de Gonzalo Calvo, David; Rodríguez, Alejandro; Barbé Illa, Ferran; Aguilera, Luciano; Amaya Villar, Rosario; Barberà, Carme; Barberán, José; Blandino Ortiz, Aaron; Bustamante Munguira, Elena; Caballero, Jesús; Carbajales, Cristina; Carbonell, Nieves; Catalán González, Mercedes; Galbán, Cristóbal; Gumucio Sanguino, Víctor D.; de la Torre, Maria del Carmen; Díaz, Emili; Gallego, Elena; García Garmendia, José Luis; Garnacho Montero, José; Gómez, José Manuel; Jorge García, Ruth Noemí; Loza Vázquez, Ana; Marin Corral, Judith; Martínez de la Gándara, Amalia; Martínez Varela, Ignacio; López Messa, Juan; Albaiceta, Guillermo M.; Novo, Mariana Andrea; Peñasco, Yhivian; Ricart, Pilar; Urrelo Cerrón, Luis; Sánchez Miralles, Angel; Sancho Chinesta, Susana; Socias, Lorenzo; Solé Violan, Jordi; Tamayo Lomas, Luis; Vidal, Pablo; Torres, Antoni (MDPI, 2021)
      Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to ...
    • Identification and validation of circulating miRNAs as endogenous controls in obstructive sleep apnea 

      Santamaría Martos, Fernando; Benítez, Iván; Zapater, Andrea; Girón, Cristina; Pinilla, Lucía; Fernandez-Real, Jose Manuel; Barbé Illa, Ferran; Ortega Delgado, Francisco José; Sánchez de la Torre, Manuel (Public Library of Science, 2019-03-13)
      microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness in clinical management. ...
    • Identification and validation of endogenous control miRNAs in plasma samples for normalization of qPCR data for Alzheimer's disease 

      Dakterzada, Farida; Targa, Adriano; Benítez, Iván; Romero El Khayat, Leila; de Gonzalo Calvo, David; Torres, Gerard; Moncusí Moix, Anna; Huerto Vilas, Raquel; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Piñol Ripoll, Gerard (BCM, 2020)
      Background. MicroRNAs (miRNAs) are noncoding RNAs that are highly relevant as disease biomarkers. Several studies that explored the role of miRNAs in Alzheimer’s disease (AD) demonstrated their usefulness in clinical ...
    • Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling 

      Comas, Jorge; Benfeitas, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Solsona Tehàs, Francesc; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Capell Capell, Teresa; Sandmann, Gerhard; Zhu, Changfu; Christou, Paul; Alves, Rui (Wiley online library, 2016)
      Plant synthetic biology is still in its infancy. However, synthetic biology approaches have been used to manipulate and improve the nutritional and health value of staple food crops such as rice, potato and maize. With ...
    • Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization 

      Guillén Gosálbez, Gonzalo; Miró, Antoni; Alves, Rui; Sorribas Tello, Albert; Jiménez Esteller, Laureano (BioMed Central, 2013)
      Background: Recovering the network topology and associated kinetic parameter values from time-series data are central topics in systems biology. Nevertheless, methods that simultaneously do both are few and lack ...
    • Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses 

      Guillén Gosálbez, Gonzalo; Sorribas Tello, Albert (BioMed Central, 2009)
      Background: Optimization methods allow designing changes in a system so that specific goals are attained. These techniques are fundamental for metabolic engineering. However, they are not directly applicable for investigating ...
    • Identifying the preferred subset of enzymatic profiles in nonlinear kinetic metabolic models via multiobjective global optimization and pareto filters 

      Pozo Fernández, Carlos; Guillén Gosálbez, Gonzalo; Sorribas Tello, Albert; Jiménez Esteller, Laureano (Public Library of Science (PLoS), 2012)
      Optimization models in metabolic engineering and systems biology focus typically on optimizing a unique criterion, usually the synthesis rate of a metabolite of interest or the rate of growth. Connectivity and non-linear ...
    • Identifying thoracic malignancies through pleural fluid biomarkers: a predictive multivariate model 

      Porcel Pérez, José Manuel; Esquerda, Aureli; Martínez Alonso, Montserrat; Bielsa Martín, Silvia; Salud Salvia, Maria Antonieta (Wolters Kluwer Health, 2016-03-01)
      The diagnosis of malignant pleural effusions may be challenging when cytological examination of aspirated pleural fluid is equivocal or noncontributory. The purpose of this study was to identify protein candidate biomarkers ...
    • IL-17A as a potential therapeutic target for patients on peritoneal dialysis 

      Marchant, Vanessa; Tejera Muñoz, Antonio; Marquez Exposito, Laura; Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Tejedor, Lucia; Santos Sanchez, Laura; Egido, Jesús; Valdivielso Revilla, José Manuel; Fraser, Donald J.; López Cabrera, Manuel; Selgas, Rafael; Ruiz-Ortega, Marta (MDPI, 2020)
      Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy ...
    • Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma 

      Maiques Carlos, Oscar; Macià Armengol, Anna; Moreno, Sara; Barceló Gómez, Carla; Santacana Espasa, Maria; Veà Jódar, Àlvar; Herreros Danés, Judit; Gatius Calderó, Sònia; Ortega Izquierdo, Maria Eugenia; Valls Marsal, Joan; Chen, Bo-Juen; Llovet Navàs, David; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Martí Laborda, Rosa Ma. (Wiley Online Library, 2016-10-08)
      BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca2+ channels (TTCs) are upregulated ...
    • Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer 

      Vrede, S. W.; Van Weelden, Willem Jan; Visser, N. C. M.; Bulten, Johan; van der Putten, Louis J. M.; van de Vijver, Koen; Santacana Espasa, Maria; Colàs Campàs, Laura; Gil-Moreno, Antonio; Moiola, Cristian P.; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, M.; Hausnerova, Jitka; van der Wurff, Anneke A. M.; Matias-Guiu, Xavier; Amant, Frederic; ENITEC Consortium; Snijders, Marc P. L. M.; Küsters-Vandevelde, Heidi V. N; Reijnen, Casper; Pijnenborg, Johanna M. A. (Elsevier, 2021)
      Objective Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ...
    • Impact of an Educational Program to Reduce Healthcare Resources in CommunityAcquired Pneumonia: The EDUCAP Randomized Controlled Trial 

      Adamuz, Jordi; Viasus, Diego; Simonetti, Antonella; Jiménez-Martínez, Emilio; Molero, Lorena; González-Samartino, Maribel; Castillo, Elena; Juvé-Udina, María-Eulalia; Alcocer, María-Jesús; Hernández, Carme; Buera, María-Pilar; Roel, Asunción; Abad, Emilia; Zabalegui, Adelaida; Ricart, Pilar; Gonzalez, Anna; Isla, Pilar; Dorca, Jordi; Garcia-Vidal, Carolina; Carratalà, Jordi (Public Library of Science, 2015)
      Background: Additional healthcare visits and rehospitalizations after discharge are frequent among patients with community-acquired pneumonia (CAP) and have a major impact on healthcare costs. We aimed to determine whether ...
    • Impact of obstructive sleep apnea on the levels of placental growth factor (PlGF) and their value for predicting short-term adverse outcomes in patients with acute coronary syndrome 

      Barceló Bennasar, Antònia; Bauçà, Josep Miquel; Yañez, Aina; Fueyo, Laura; Gomez, Cristina; Peña, Mónica de la; Pierola, Javier; Rodriguez, Alberto; Sánchez de la Torre, Manuel; Abad, Jorge; Mediano, Olga; Amilibia, Jose; Masdeu, María José; Terán, Joaquin; Montserrat i Capdevila, Josep; Mayos, Mercè; Sánchez de la Torre, Alicia; Barbé Illa, Ferran (Public Library of Science, 2016)
      Background Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea ...
    • Impact of One-Catheter Strategy with TIG I Catheter on Coronary Catheterization Performance and Economic Costs 

      Costa-Mateu, Joan; Fernández-Rodríguez, Diego; Rivera, Kristian; Casanova, Juan; Irigaray, Patricia; Zielonka, Marta; Pereyra-Acha, Eduardo; Aldomá, Albina; Worner, Fernando (Sociedade Brasileira de Cardiologia, 2019)
      Background: Coronary angiography with two catheters is the traditional strategy for diagnostic coronary procedures. TIG I catheter permits to cannulate both coronary arteries, avoiding exchanging catheters during coronary ...
    • Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme 

      Blanch, Jordi; Sala i Serra, Maria; Ibáñez, Josefa; Domingo, Laia; Fernández, Belén; Otegi, Arantza; Barata, Teresa; Zubizarreta, Raquel; Ferrer, Joana; Castells, Xavier; Rué i Monné, Montserrat; Salas, Dolores; Interval Cancer Study Group (Public Library of Science, 2014-10-21)
      Background: Interval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes ...
    • Impact of sleep health on self-perceived health status 

      Dalmases, Mireia; Benítez, Iván; Sapiña Beltrán, Esther; Garcia-Codina, Oriol; Medina-Bustos, Antonia; Escarrabill, Joan; Saltó, Esteve; Buysse, Daniel J.; Plana, Rosa E.; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Batlle Garcia, Jordi de (Nature Publishing Group, 2019-05)
      Although sleep habits have long been recognized as a promoter of health, the World Health Organization 2014 report on non-communicable diseases (NCDs) only listed smoking, alcohol intake, diet and physical activity (PA) ...
    • Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study 

      González, Jessica; Benítez, Iván; de Gonzalo Calvo, David; Torres, Gerard; Batlle Garcia, Jordi de; Gómez Falguera, Silvia; Moncusí Moix, Anna; Carmona, Paola; Santisteve, Sally; Monge Esqué, Aida; Gort Paniello, Clara; Zuil, María; Cabo Gambín, Ramón; Manzano Senra, Carlos; Vengoechea Aragoncillo, José Javier; Vaca, Rafaela; Minguez Roure, Olga; Aguilar, María; Ferrer, Ricard; Ceccato, Adrián; Fernández Barat, Laia; Motos, Anna; Riera, Jordi; Menéndez, Rosario; García Gasulla, Dario; Peñuelas, Oscar; Labarca Trucios, Gonzalo; Caballero, Jesús; Barberà, Carme; Torres, Antoni; Barbé Illa, Ferran (BCM, 2022)
      Question: We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials ...
    • Impact on polytrauma patient prehospital care during the first wave of the COVID‑19 pandemic: a cross‑sectional study 

      Solà, Silvia; Yuguero Torres, Oriol; Roig, Guillermo; Prieto Arruñada, José Antonio; Español, Jaume; Morales Álvarez, Jorge; Muñoz, Manuel; Verge, Juan José; Jiménez Fàbrega, Xavier (Springer, 2021)
      Background The extraordinary situation caused by the onset of COVID-19 has meant that at prehospital level, the number of treatments, profle and time taken to respond for treating time-dependent pathologies has been greatly ...
    • Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators 

      Pijuan Marquilles, Jordi; Marı́a, Carlos; Herrero Perpiñán, Enrique; Bellí i Martínez, Gemma (The Company of Biologists, 2015)
      Fe-S cluster biogenesis machinery is required for multiple DNA metabolism processes. In this work, we show that, in Saccharomyces cerevisiae, defects at different stages of the mitochondrial Fe-S cluster assembly machinery ...
    • Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy 

      López Erauskin, Jone; Galino, Jorge; Ruiz, M.; Cuezva, J. M.; Fabregat, I.; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Martínez, Juan José; Ferrer, Isidre; Pamplona Gras, Reinald; Villarroya, Francesc; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, A. (Oxford Journals, 2013)
      X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ...