Now showing items 448-467 of 935

    • Identification and validation of circulating miRNAs as endogenous controls in obstructive sleep apnea 

      Santamaría Martos, Fernando; Benítez, Iván; Zapater, Andrea; Girón, Cristina; Pinilla, Lucía; Fernandez-Real, Jose Manuel; Barbé Illa, Ferran; Ortega Delgado, Francisco José; Sánchez de la Torre, Manuel (Public Library of Science, 2019-03-13)
      microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness in clinical management. ...
    • Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling 

      Comas, Jorge; Benfeitas, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Solsona Tehàs, Francesc; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Capell Capell, Teresa; Sandmann, Gerhard; Zhu, Changfu; Christou, Paul; Alves, Rui (Wiley online library, 2016)
      Plant synthetic biology is still in its infancy. However, synthetic biology approaches have been used to manipulate and improve the nutritional and health value of staple food crops such as rice, potato and maize. With ...
    • Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization 

      Guillén Gosálbez, Gonzalo; Miró, Antoni; Alves, Rui; Sorribas Tello, Albert; Jiménez Esteller, Laureano (BioMed Central, 2013)
      Background: Recovering the network topology and associated kinetic parameter values from time-series data are central topics in systems biology. Nevertheless, methods that simultaneously do both are few and lack ...
    • Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses 

      Guillén Gosálbez, Gonzalo; Sorribas Tello, Albert (BioMed Central, 2009)
      Background: Optimization methods allow designing changes in a system so that specific goals are attained. These techniques are fundamental for metabolic engineering. However, they are not directly applicable for investigating ...
    • Identifying the preferred subset of enzymatic profiles in nonlinear kinetic metabolic models via multiobjective global optimization and pareto filters 

      Pozo Fernández, Carlos; Guillén Gosálbez, Gonzalo; Sorribas Tello, Albert; Jiménez Esteller, Laureano (Public Library of Science (PLoS), 2012)
      Optimization models in metabolic engineering and systems biology focus typically on optimizing a unique criterion, usually the synthesis rate of a metabolite of interest or the rate of growth. Connectivity and non-linear ...
    • Identifying thoracic malignancies through pleural fluid biomarkers: a predictive multivariate model 

      Porcel Pérez, José Manuel; Esquerda, Aureli; Martínez Alonso, Montserrat; Bielsa Martín, Silvia; Salud Salvia, Maria Antonieta (Wolters Kluwer Health, 2016-03-01)
      The diagnosis of malignant pleural effusions may be challenging when cytological examination of aspirated pleural fluid is equivocal or noncontributory. The purpose of this study was to identify protein candidate biomarkers ...
    • IL-17A as a potential therapeutic target for patients on peritoneal dialysis 

      Marchant, Vanessa; Tejera Muñoz, Antonio; Marquez Exposito, Laura; Rayego Mateos, Sandra; Rodrigues-Diez, Raul; Tejedor, Lucia; Santos Sanchez, Laura; Egido, Jesús; Valdivielso Revilla, José Manuel; Fraser, Donald J.; López Cabrera, Manuel; Selgas, Rafael; Ruiz-Ortega, Marta (MDPI, 2020)
      Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy ...
    • Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma 

      Maiques Carlos, Oscar; Macià Armengol, Anna; Moreno, Sara; Barceló Gómez, Carla; Santacana Espasa, Maria; Veà Jódar, Àlvar; Herreros Danés, Judit; Gatius Calderó, Sònia; Ortega Izquierdo, Maria Eugenia; Valls Marsal, Joan; Chen, Bo-Juen; Llovet Navàs, David; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Martí Laborda, Rosa Ma. (Wiley Online Library, 2016-10-08)
      BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca2+ channels (TTCs) are upregulated ...
    • Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer 

      Vrede, S. W.; van Weelden, W. J.; Visser, N. C. M.; Bulten, Johan; van der Putten, Louis J. M.; van de Vijver, Koen; Santacana, M.; Colas, L.; Gil-Moreno, Antonio; Moiola, Cristian P.; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, M.; Hausnerova, J.; van der Wurff, Anneke A. M.; Matias-Guiu, Xavier; Amant, Frederic; ENITEC Consortium; Snijders, Marc P. L. M.; Küsters-Vandevelde, H. V. N; Reijnen, C.; Pijnenborg, Johanna M. A. (Elsevier, 2021)
      Objective Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ...
    • Impact of an Educational Program to Reduce Healthcare Resources in CommunityAcquired Pneumonia: The EDUCAP Randomized Controlled Trial 

      Adamuz, Jordi; Viasus, Diego; Simonetti, Antonella; Jiménez-Martínez, Emilio; Molero, Lorena; González-Samartino, Maribel; Castillo, Elena; Juvé-Udina, María-Eulalia; Alcocer, María-Jesús; Hernández, Carme; Buera, María-Pilar; Roel, Asunción; Abad, Emilia; Zabalegui, Adelaida; Ricart, Pilar; Gonzalez, Anna; Isla, Pilar; Dorca, Jordi; Garcia-Vidal, Carolina; Carratalà, Jordi (Public Library of Science, 2015)
      Background: Additional healthcare visits and rehospitalizations after discharge are frequent among patients with community-acquired pneumonia (CAP) and have a major impact on healthcare costs. We aimed to determine whether ...
    • Impact of obstructive sleep apnea on the levels of placental growth factor (PlGF) and their value for predicting short-term adverse outcomes in patients with acute coronary syndrome 

      Barceló Bennasar, Antònia; Bauçà, Josep Miquel; Yañez, Aina; Fueyo, Laura; Gomez, Cristina; Peña, Mónica de la; Pierola, Javier; Rodriguez, Alberto; Sánchez de la Torre, Manuel; Abad, Jorge; Mediano, Olga; Amilibia, Jose; Masdeu, María José; Terán, Joaquin; Montserrat i Capdevila, Josep; Mayos, Mercè; Sánchez de la Torre, Alicia; Barbé Illa, Ferran (Public Library of Science, 2016)
      Background Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea ...
    • Impact of One-Catheter Strategy with TIG I Catheter on Coronary Catheterization Performance and Economic Costs 

      Costa-Mateu, Joan; Fernández-Rodríguez, Diego; Rivera, Kristian; Casanova, Juan; Irigaray, Patricia; Zielonka, Marta; Pereyra-Acha, Eduardo; Aldomá, Albina; Worner, Fernando (Sociedade Brasileira de Cardiologia, 2019)
      Background: Coronary angiography with two catheters is the traditional strategy for diagnostic coronary procedures. TIG I catheter permits to cannulate both coronary arteries, avoiding exchanging catheters during coronary ...
    • Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme 

      Blanch, Jordi; Sala i Serra, Maria; Ibáñez, Josefa; Domingo, Laia; Fernández, Belén; Otegi, Arantza; Barata, Teresa; Zubizarreta, Raquel; Ferrer, Joana; Castells, Xavier; Rué i Monné, Montserrat; Salas, Dolores; Interval Cancer Study Group (Public Library of Science, 2014-10-21)
      Background: Interval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes ...
    • Impact of sleep health on self-perceived health status 

      Dalmases, Mireia; Benítez, Iván; Sapiña Beltrán, Esther; Garcia-Codina, Oriol; Medina-Bustos, Antonia; Escarrabill, Joan; Saltó, Esteve; Buysse, Daniel J.; Plana, Rosa E.; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Batlle Garcia, Jordi de (Nature Publishing Group, 2019-05)
      Although sleep habits have long been recognized as a promoter of health, the World Health Organization 2014 report on non-communicable diseases (NCDs) only listed smoking, alcohol intake, diet and physical activity (PA) ...
    • Impact on polytrauma patient prehospital care during the first wave of the COVID‑19 pandemic: a cross‑sectional study 

      Solà, Silvia; Yuguero Torres, Oriol; Roig, Guillermo; Prieto Arruñada, José Antonio; Español, Jaume; Morales Álvarez, Jorge; Muñoz, Manuel; Verge, Juan José; Jiménez Fàbrega, Xavier (Springer, 2021)
      Background The extraordinary situation caused by the onset of COVID-19 has meant that at prehospital level, the number of treatments, profle and time taken to respond for treating time-dependent pathologies has been greatly ...
    • Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators 

      Pijuan Marquilles, Jordi; Marı́a, Carlos; Herrero Perpiñán, Enrique; Bellí i Martínez, Gemma (The Company of Biologists, 2015)
      Fe-S cluster biogenesis machinery is required for multiple DNA metabolism processes. In this work, we show that, in Saccharomyces cerevisiae, defects at different stages of the mitochondrial Fe-S cluster assembly machinery ...
    • Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy 

      López Erauskin, Jone; Galino, Jorge; Ruiz, M.; Cuezva, J. M.; Fabregat, I.; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Martínez, Juan José; Ferrer, Isidre; Pamplona Gras, Reinald; Villarroya, Francesc; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, A. (Oxford Journals, 2013)
      X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ...
    • Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Vall-llaura Espinosa, Núria; Vived Maza, Celia; Fernández Nogales, Marta; Lucas, José J.; Ferrer, Isidre; Cabiscol Català, Elisa (Springer Science, Business Media, 2016-06)
      Oxidative stress has been described as important to Huntington disease (HD) progression. In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are ...
    • Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development 

      Dolcet Roca, Xavier; Encinas Martín, Mario; Bozić Stanojević, Milica; Álvarez, Ángeles; Pablo, Carmen de; Sanchez-Niño, Maria-Dolores; Ortiz, Alberto; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Public Library of Science, 2015)
      Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation and progression of atherosclerosis. Vitamin D has cardioprotective actions, while its deficiency is a risk ...
    • Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients 

      Gonzalo Benito, Hugo; Nogueras Penabad, Lara; Gil-Sánchez, Anna; Vicente Hervás, José; Valcheva, Petya; González Mingot, Cristina; Martin-Gari, Meritxell; Canudes, Marc; Peralta Moncusí, Silvia; Solana Moga, M. José; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Brieva Ruiz, Luis (Frontiers Media, 2019)
      Literature suggests that oxidative stress (OS) may be involved in the pathogenesis of multiple sclerosis (MS), in which the immune system is known to play a key role. However, to date, the OS in peripheral lymphocytes and ...