Now showing items 105-124 of 1083

    • B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse 

      Carrascal, Jorge; Carrillo, Jorge; Arpa i Puigdemont, Berta; Egia-Mendikute, Leire; Rosell Mases, Estela; Pujol Autonell, Irma; Planas, Raquel; Mora Giral, Concepció; Mauricio Puente, Dídac; Ampudia, Rosa Maria; Vives Pi, Marta; Verdaguer Autonell, Joan (Wiley online library, 2016)
      Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the ...
    • B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes 

      Egia-Mendikute, Leire; Arpa i Puigdemont, Berta; Rosell Mases, Estela; Corral Pujol, Marta; Carrascal, Jorge; Carrillo, Jorge; Mora Giral, Concepció; Chapman, Harold; Panosa, Anaïs; Vives Pi, Marta; Stratmann, Thomas; Serreze, David; Verdaguer Autonell, Joan (Frontiers Media, 2019)
      Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ...
    • B-Type Natriuretic Peptides Help in Cardioembolic Stroke Diagnosis: Pooled Data Meta-Analysis. 

      Llombart Sebastià, Víctor; Antolin-Fontes, Albert; Bustamante Rangel, Alejandro; Giralt Casellas, Dolors; Rost, Natalia S.; Furie, Karen; Shibazaki, Kensaku; Biteker, Murat; Castillo, José; Rodríguez-Yáñez, Manuel; Fonseca, Ana Caterina; Watanabe, Tetsu; Purroy Garcia, Francisco; Zhixin, Wu; Etgen, Thorleif; Hosomi, Naohisa; Kerman, Scott Reza Jafarian; Sharma, Jagdish C.; Knauer, Carolin; Santamarina Pérez, Estevo; Giannakoulas, George; García Berrocoso, Teresa; Montaner Villalonga, Joan (American Heart Association, 2015-03-12)
      Background and Purpose. Determining the underlying cause of stroke is important to optimize secondary prevention treatment. Increased blood levels of natriuretic peptides (B-type natriuretic peptide/N-terminal pro-BNP ...
    • Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells 

      Varano della Vergiliana, Julius F.; Lansley, Sally M.; Porcel Pérez, José Manuel; Bielsa Martín, Silvia; Brown, Jeremy S.; Creaney, Jenette; Temple, Suzanna E. L.; Waterer, Grant W.; Gary Lee, Y. C. (Public Library of Science, 2013)
      Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response ...
    • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

      Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
      β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
    • Barriers and facilitators to the implementation of a personalized breast cancer screening program: Views of Spanish health professionals 

      Laza-Vásquez, Celmira; Hernández-Leal, María José; Carles Lavila, Misericordia; Pérez Lacasta, María José; Cruz Esteve, María Inés; Rué i Monné, Montserrat (MDPI, 2022)
      Abstract:This study explored the barriers and facilitators to the implementation of a risk-basedbreast cancer screening program from the point of view of Spanish health professionals. A cross-sectional study with 220 ...
    • BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis 

      Garrofé Ochoa, Xènia; Melero Fernández de Mera, Raquel M; Fernández Gómez, Francisco J.; Ribas i Fortuny, Judit; Jordán Bueso, Joaquín; Boix Torras, Jacint (American Association for Cancer Research, 2008)
      In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ...
    • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

      Armero, Carmen; Forné Izquierdo, Carles; Rué i Monné, Montserrat; Forte, Anabel; Perpiñán, Hèctor; Gómez, Guadalupe; Baré, Marisa (Wiley, 2016)
      We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...
    • Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast 

      Ferrezuelo, Francisco; Aldea, Martí; Futcher, Bruce (Landes Bioscience, 2009)
      During the cell division cycle of the yeast Saccharomyces cerevisiae, the G1-to-S transition depends upon the activation of two transcription factors (SBF and MBF), which are responsible for the cell cycle-regulated ...
    • Benign and malignant nodular thyroid disease in acromegaly. Is a routine thyroid ultrasound evaluation advisable? 

      Reverter, Jordi L.; Fajardo, Carmen; Resmini, Eugenia; Salinas, Isabel; Mora, Mireia; Llatjós, Mariona; Sesmilo, Gemma; Rius, Ferran; Halperin, Irene; Webb, Susan M.; Ricart, Veronica; Riesgo, Pedro; Mauricio Puente, Dídac; Puig-Domingo, Manuel (Public Library of Science (PLoS), 2014)
      Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this ...
    • Bevacizumab plus preoperative chemotherapy in operable HER2 negative breast cancer: biomarkers and pathologic response 

      Sánchez Rovira, Pedro; Seguí, M. A.; Llombart, A.; Aranda, Enrique; Antón, Antonio; Sánchez, A.; Lomas, M.; Jaén, A.; Fernández, M.; Porras, I.; Dalmau, E.; Morales Murillo, Serafín; Haba-Rodríguez, J. de la (Springer, 2013)
      Purpose: The primary aim of this trial was to assess the rate of pathologic complete responses (pCR) of doxorubicin/cyclophosphamide (AC) followed by bevacizumab/docetaxel (BT), as neoadjuvant therapy for breast cancer ...
    • Biblio-MetReS for user-friendly mining of genes and biological processes in scientific documents 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Alves, Rui; Solsona Tehàs, Francesc (PeerJ, 2014)
      One way to initiate the reconstruction of molecular circuits is by using automated text-mining techniques. Developing more efficient methods for such reconstruction is a topic of active research, and those methods are ...
    • Biblio-MetReS: A bibliometric network reconstruction application and server 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Valls Marsal, Joan; Faus i Torà, Xavier; Alves, Rui; Solsona Tehàs, Francesc (BioMed Central, 2011)
      Background: Reconstruction of genes and/or protein networks from automated analysis of the literature is one of the current targets of text mining in biomedical research. Some user-friendly tools already perform this ...
    • Bin-CE: A comprehensive web application to decide upon the best set of outcomes to be combined in a binary composite endpoint 

      Marsal Mora, Josep Ramon; Ferreira-González, Ignacio; Ribera, Aida; Oristrell, Gerard; Pijoan, Jose Ignacio; García-Dorado, David (Public Library of Science, 2018)
      The estimation of the Sample Size Requirement (SSR) when using a binary composite endpoint (i.e. two or more outcomes combined in a unique primary endpoint) is not trivial. Besides information about the rate of events for ...
    • Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin 

      Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2003)
      Grx5 is a yeast mitochondrial protein involved in iron- sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins. No member of this family has been biochemically charac- terized ...
    • Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness 

      Ruiz‑Plazas, Xavier; Rodríguez‑Gallego, Esther; Alves, Marta; Altuna Coy, Antonio; Lozano‑Bartolomé, Javier; Portero Otín, Manuel; García‑Fontgivell, Joan Francesc; Martínez‑González, Salomé; Segarra, José; Chacón, Matilde R. (BMC (part of Springer Nature), 2019)
      Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ...
    • Biofortification of crops with nutrients: factors affecting utilization and storage 

      Díaz Gómez, Joana; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
      Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
    • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

      Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
      X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
    • Biomarkers of aging in Drosophila 

      Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
      Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
    • Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer 

      Alonso-Alconada, Lorena; de la Fuente, Alexandre; Santacana Espasa, Maria; Ferreiros, Alba; Lopez Lopez, Rafael; Matias-Guiu, Xavier; Abal, Miguel (The Company of Biologists, 2020)
      Metastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for ...