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dc.contributor.authorGayán, Javier
dc.contributor.authorGalan, José J.
dc.contributor.authorGonzález-Pérez, Antonio
dc.contributor.authorSáez, María Eugenia
dc.contributor.authorMartínez-Larrad, María Teresa
dc.contributor.authorZabena, Carina
dc.contributor.authorRivero, M. Carmen
dc.contributor.authorSalinas, Ana
dc.contributor.authorRamírez-Lorca, Reposo
dc.contributor.authorMorón, Francisco J.
dc.contributor.authorRoyo Sánchez-Palencia, José Luis
dc.contributor.authorMoreno-Rey, Concha
dc.contributor.authorVelasco, Juan
dc.contributor.authorCarrasco, José M.
dc.contributor.authorMolero, Eva
dc.contributor.authorOchoa, Carolina
dc.contributor.authorOchoa, María Dolores
dc.contributor.authorGutiérrez, Marta
dc.contributor.authorReina, Mercedes
dc.contributor.authorPascual, Rocío
dc.contributor.authorRomo-Astorga, Alejandro
dc.contributor.authorSusillo-González, Juan Luis
dc.contributor.authorVázquez, Enrique
dc.contributor.authorReal, Luis M.
dc.contributor.authorRuiz, Agustín
dc.contributor.authorSerrano-Ríos, Manuel
dc.description.abstractBackground Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
dc.description.sponsorshipThis work was supported in part by Agencia IDEA, Consejería de Innovación, Ciencia y Empresa (830882); Corporación Tecnológica de Andalucía (07/124); Ministerio de Educación y Ciencia (PCT-A41502790-2007 and PCT-010000-2007-18); Programa de Ayudas Torres Quevedo del Ministerio de Ciencia en Innovación (PTQ2002-0206, PTQ2003-0549, PTQ2003-0546, PTQ2003-0782, PTQ2003-0783, PTQ2004-0838, PTQ04-1-0006, PTQ04-3-0718, PTQ06-1-0002). CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) is an ISCIII project.
dc.publisherBioMed Central
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofBmc Genomics, 2010, vol. 11, p. 1-15
dc.rightscc-by (c) Gayán, Javier et al., 2010
dc.subject.classificationGenètica de poblacions humanes
dc.subject.otherHuman population genetics
dc.titleGenetic structure of the Spanish population

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