Genetic structure of the Spanish population

Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; Rivero, M. Carmen; Salinas, Ana; Ramírez-Lorca, Reposo; Morón, Francisco J.; Royo Sánchez-Palencia, José Luis; Moreno-Rey, Concha; Velasco, Juan; Carrasco, José M.; Molero, Eva; Ochoa, Carolina; Ochoa, María Dolores; Gutiérrez, Marta; Reina, Mercedes; Pascual, Rocío; Romo-Astorga, Alejandro; Susillo-González, Juan Luis; Vázquez, Enrique; Real, Luis M.; Ruiz, Agustín; Serrano-Ríos, Manuel

doi:https://doi.org/10.1186/1471-2164-11-326

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Issue date

2010-05-25

Author

Gayán, Javier

Galan, José J.

González-Pérez, Antonio

Sáez, María Eugenia

Martínez-Larrad, María Teresa

Zabena, Carina

Rivero, M. Carmen

Salinas, Ana

Ramírez-Lorca, Reposo

Morón, Francisco J.

Royo Sánchez-Palencia, José Luis

Moreno-Rey, Concha

Velasco, Juan

Carrasco, José M.

Molero, Eva

Ochoa, Carolina

Ochoa, María Dolores

Gutiérrez, Marta

Reina, Mercedes

Pascual, Rocío

Romo-Astorga, Alejandro

Susillo-González, Juan Luis

Vázquez, Enrique

Real, Luis M.

Ruiz, Agustín

Serrano-Ríos, Manuel

Suggested citation

Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; ... Serrano-Ríos, Manuel. (2010) . Genetic structure of the Spanish population. Bmc Genomics, 2010, vol. 11, p. 1-15. https://doi.org/10.1186/1471-2164-11-326.

Abstract

Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the population

of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.

URI

http://hdl.handle.net/10459.1/59988

DOI

https://doi.org/10.1186/1471-2164-11-326

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Bmc Genomics, 2010, vol. 11, p. 1-15

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Except where otherwise noted, this item's license is described as cc-by (c) Gayán, Javier et al., 2010