Genetic structure of the Spanish population

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2010-05-25
Author
Gayán, Javier
Galan, José J.
González-Pérez, Antonio
Sáez, María Eugenia
Martínez-Larrad, María Teresa
Zabena, Carina
Rivero, M. Carmen
Salinas, Ana
Ramírez-Lorca, Reposo
Morón, Francisco J.
Royo Sánchez-Palencia, José Luis
Moreno-Rey, Concha
Velasco, Juan
Carrasco, José M.
Molero, Eva
Ochoa, Carolina
Ochoa, María Dolores
Gutiérrez, Marta
Reina, Mercedes
Pascual, Rocío
Romo-Astorga, Alejandro
Susillo-González, Juan Luis
Vázquez, Enrique
Real, Luis M.
Ruiz, Agustín
Serrano-Ríos, Manuel
Suggested citation
Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; ... Serrano-Ríos, Manuel. (2010) . Genetic structure of the Spanish population. Bmc Genomics, 2010, vol. 11, p. 1-15. https://doi.org/10.1186/1471-2164-11-326.
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Abstract
Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
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http://hdl.handle.net/10459.1/59988
DOI
https://doi.org/10.1186/1471-2164-11-326
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Bmc Genomics, 2010, vol. 11, p. 1-15
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cc-by (c) Gayán, Javier et al., 2010
Except where otherwise noted, this item's license is described as cc-by (c) Gayán, Javier et al., 2010