Baseline residual kidney function and its ensuing rate of decline interact to predict mortality of peritoneal dialysis patients

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2016Author
Pérez Fontán, Miguel
Remón Rodríguez, César
Cunha Naveira, Marta da
Rodríguez Suárez, Carmen
Quirós Ganga, Pedro
Sánchez Álvarez, Emilio
Rodríguez Carmona, Ana
Suggested citation
Pérez Fontán, Miguel;
Remón Rodríguez, César;
Cunha Naveira, Marta da;
Borràs, Mercè;
Rodríguez Suárez, Carmen;
Quirós Ganga, Pedro;
...
Rodríguez Carmona, Ana.
(2016)
.
Baseline residual kidney function and its ensuing rate of decline interact to predict mortality of peritoneal dialysis patients.
Plos One, 2016, vol. 11, núm. 7, p. 1-11.
https://doi.org/10.1371/journal.pone.0158696.
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Background
Baseline residual kidney function (RKF) and its rate of decline during follow-up are purported
to be reliable outcome predictors of patients undergoing Peritoneal Dialysis (PD).
The independent contribution of each of these factors has not been elucidated.
Method
We report a multicenter, longitudinal study of 493 patients incident on PD and satisfying two
conditions: a glomerular filtration rate (GFR) 1 mL/minute and a daily diuresis 300 mL.
The main variables were the GFR (mean of urea and creatinine clearances) at PD inception
and the GFR rate of decline during follow-up. The main outcome variable was patient mortality.
The secondary outcome variables were: PD technique failure and risk of peritoneal
infection. The statistical analysis was based on a multivariate approach, placing an emphasis
on the interactions between the two main study variables.
Is part of
Plos One, 2016, vol. 11, núm. 7, p. 1-11European research projects
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