Baseline residual kidney function and its ensuing rate of decline interact to predict mortality of peritoneal dialysis patients

Pérez Fontán, Miguel; Remón Rodríguez, César; Cunha Naveira, Marta da; Borràs, Mercè; Rodríguez Suárez, Carmen; Quirós Ganga, Pedro; Sánchez Alvarez, Emilio; Rodríguez Carmona, Ana

doi:https://doi.org/10.1371/journal.pone.0158696

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Issue date

2016

Author

Pérez Fontán, Miguel

Remón Rodríguez, César

Cunha Naveira, Marta da

Borràs, Mercè

Rodríguez Suárez, Carmen

Quirós Ganga, Pedro

Sánchez Alvarez, Emilio

Rodríguez Carmona, Ana

Abstract

Background Baseline residual kidney function (RKF) and its rate of decline during follow-up are purported to be reliable outcome predictors of patients undergoing Peritoneal Dialysis (PD). The independent contribution of each of these factors has not been elucidated. Method We report a multicenter,

longitudinal study of 493 patients incident on PD and satisfying two conditions: a glomerular filtration rate (GFR) 1 mL/minute and a daily diuresis 300 mL. The main variables were the GFR (mean of urea and creatinine clearances) at PD inception and the GFR rate of decline during follow-up. The main outcome variable was patient mortality. The secondary outcome variables were: PD technique failure and risk of peritoneal infection. The statistical analysis was based on a multivariate approach, placing an emphasis on the interactions between the two main study variables.