In vitro metabolomic approaches to investigating the potential biological effects of phenolic compounds: an update

Catalán Santos, Úrsula; Barrubés Piñol, Laura; Maria Valls, Rosa; Solà, Rosa; Rubió Piqué, Laura

doi:https://doi.org/10.1016/j.gpb.2016.12.007

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Issue date

2017

Author

Catalán Santos, Úrsula

Barrubés Piñol, Laura

Maria Valls, Rosa

Solà, Rosa

Rubió Piqué, Laura

Suggested citation

Catalán Santos, Úrsula; Barrubés Piñol, Laura; Maria Valls, Rosa; Solà, Rosa; Rubió Piqué, Laura; . (2017) . In vitro metabolomic approaches to investigating the potential biological effects of phenolic compounds: an update. Genomics Proteomics Bioinformatics, 2017, vol. 15, núm. 4, p. 236-245. https://doi.org/10.1016/j.gpb.2016.12.007.

Abstract

Dietary phenolic compounds (PCs) have been receiving interest for their presumed roles in disease prevention. However, there is a lack of studies on the underlying molecular mechanisms. In this regard, in vitro metabolomic approaches are suitable for the investigation of the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been examined for PCs from rosemary (Rosmarinus officinalis), olive oil, and resveratrol using cell-based metabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vitro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro- and micro-nutrient metabolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerative diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are needed and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

URI

http://hdl.handle.net/10459.1/59935

DOI

https://doi.org/10.1016/j.gpb.2016.12.007

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Genomics Proteomics Bioinformatics, 2017, vol. 15, núm. 4, p. 236-245

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Except where otherwise noted, this item's license is described as cc-by (c) Barrubés et al., 2017