In vitro metabolomic approaches to investigating the potential biological effects of phenolic compounds: an update

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2017Suggested citation
Catalán Santos, Úrsula;
Barrubés Piñol, Laura;
Maria Valls, Rosa;
Solà, Rosa;
Rubió Piqué, Laura;
.
(2017)
.
In vitro metabolomic approaches to investigating the potential biological effects of phenolic compounds: an update.
Genomics Proteomics Bioinformatics, 2017, vol. 15, núm. 4, p. 236-245.
https://doi.org/10.1016/j.gpb.2016.12.007.
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Show full item recordAbstract
Dietary phenolic compounds (PCs) have been receiving interest for their presumed roles in
disease prevention. However, there is a lack of studies on the underlying molecular mechanisms. In
this regard, in vitro metabolomic approaches are suitable for the investigation of the molecular
changes in response to PC exposure. Up to date, the biological effects of PCs have only been examined
for PCs from rosemary (Rosmarinus officinalis), olive oil, and resveratrol using cell-based metabolomic
approach, although transcriptomic and/or proteomic studies have also been conducted in
the same in vitro cell experiment in some cases. Our integral analysis of the reviewed studies suggest
that PCs may be involved not only in basic cellular processes or macro- and micro-nutrient metabolism,
but also in specific metabolic pathways that have been thoroughly investigated. These modulated
pathways could have a clinical impact on neurodegenerative diseases, type 2 diabetes, cancer,
and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional
information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order
to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are needed and
testing the physiological conjugated forms of PCs in these cell systems could be of special interest.
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Genomics Proteomics Bioinformatics, 2017, vol. 15, núm. 4, p. 236-245European research projects
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