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dc.contributor.authorArcidiacono, Maria V.
dc.contributor.authorMartínez Alonso, Montserrat
dc.contributor.authorBelart, Montserrat
dc.contributor.authorVilar, Ana
dc.contributor.authorMartín, Marisa
dc.contributor.authorCraver Hospital, Lourdes
dc.contributor.authorBetriu i Bars, M. Àngels
dc.contributor.authorMauricio Puente, Dídac
dc.contributor.authorValdivielso Revilla, José Manuel
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorBorràs, Mercè
dc.date.accessioned2017-06-16T07:50:18Z
dc.date.available2017-06-16T07:50:18Z
dc.date.issued2017-01-04
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/10459.1/59889
dc.description.abstractChronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefore, the aim of the study was to (1) evaluate if the carotid aVV in CKD patients increases in comparison to its physiological value of healthy patients; (2) explore which traditional or nontraditional risk factor including inflammation, bone and mineral metabolism, and anemia could be related to the aVV angiogenesis. CKD patients without previous cardiovascular events (44, stages 3-4; 37, stage 5D) and 65 healthy subjects were compared. The carotid aVV and the intima-media thickness (cIMT) were evaluated by ultrasound. CKD patients at stages 3-4 showed higher aVV of the right carotid artery even after adjusting for age. Importantly, a multiple linear regression model showed hemoglobin levels > 12.5 g/dL as the factor for an estimated higher aVV of the right carotid artery. In conclusion, the association of hemoglobin with higher aVV could suggest the role of high hemoglobin in the higher incidence of adverse cardiovascular outcomes in CKD patients.
dc.description.sponsorshipThis study was funded by the Health Institute Carlos III, Ministry of Economy and Competitiveness, Spain, Grants no. PI09/1999.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherHindawi
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1155/2017/3795142
dc.relation.ispartofMediators of Inflammation, 2017, vol. 2017, p. 1-11
dc.rightscc-by (c) Arcidiacono, Maria V. et al., 2017
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.subject.classificationInsuficiència renal crònica
dc.subject.classificationHemoglobina
dc.subject.classificationAngiogènesi
dc.subject.otherChronic renal failure
dc.subject.otherHemoglobin
dc.subject.otherNeovascularization
dc.titleHigh levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2017-06-16T07:50:18Z
dc.identifier.idgrec025262
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1155/2017/3795142


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cc-by (c) Arcidiacono, Maria V. et al., 2017
Except where otherwise noted, this item's license is described as cc-by (c) Arcidiacono, Maria V. et al., 2017