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dc.contributor.authorLópez de las Hazas Mingo, María del Carmen
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorKotronoulas, Aristotelis
dc.contributor.authorDe la Torre, Rafael
dc.contributor.authorSolà, Rosa
dc.contributor.authorMotilva Casado, Mª José
dc.date.accessioned2017-04-20T11:34:04Z
dc.date.available2017-04-20T11:34:04Z
dc.date.issued2015
dc.identifier.issn1613-4125
dc.identifier.urihttp://hdl.handle.net/10459.1/59519
dc.description.abstractHydroxytyrosol (HT) is the most prominent phenolic compound of virgin olive oil and due to its scientifically validated biological activities it is entering to the market as a potentially useful supplement for cardiovascular disease prevention. The aim of the present study was to investigate the relationship between the HT dose intake and its tissue uptake in rats, and thus, providing complementary information in relation to the target-dose relationship. Rats were given a refined olive oil enriched with HT at different doses (1, 10, and 100 mg/kg) and they were sacrificed after 5 h to ensure the cell tissue uptake of HT and its metabolites. Plasma samples and different organs as liver, kidney, heart and brain were obtained, and HT metabolites were analyzed by UPLC-MS/MS. The results showed that HT and its metabolites could be accumulated in a dose-dependent manner basically in the liver, kidney, and brain and were detected in these tissues even at nutritionally relevant human doses. The detection of free HT in liver and kidney was noteworthy. To date, this appears to be the only biologically active form, and thus, it provides relevant information for optimizing the potential applications of HT to prevent certain hepatic and renal diseases. In recent years, HT and its derivatives have led to a great interest from the virgin olive oil producers and manufacturers of nutraceutical supplements. The increasing interest in HT is mainly due to the European Food Safety Agency (EFSA) Panel on Dietetic Products, Nutrition, and Allergies (NDA) scientific opinion that established a cause-and-effect relationship between the consumption of olive oil polyphenols and protection of LDL particles from oxidative damage [1]. Based on this positive opinion, the health claim “Olive oil polyphenols contribute to the protection of blood lipids from oxidative stress” was included in the list of health claims [2], being the only authorized health claim in the European Union regarding polyphenols and health.ca_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Education and Science (AGL2012-40144-C03-03, AGL2012-40144- C03-02 and AGL2012-40144-C03-01 projects), by the University of Lleida through the M.C. L´opez de las Hazas and L. Rubi´o grant. CIBERobn is an iniciative of Instituto de Salud Carlos III (ISCIII). The authors are grateful for the generous gift of hydroxytyrosol from Seprox Biotech, Madrid, Spainca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICINN/PN2008-2011/AGL2012-40114-C03-01ca_ES
dc.relationMICINN/PN2008-2011/AGL2012-40114-C03-02ca_ES
dc.relationMICINN/PN2008-2011/AGL2012-40114-C03-03ca_ES
dc.relation.isformatofVersió postprint del document publicat a https://doi.org/10.1002/mnfr.201500048ca_ES
dc.relation.ispartofMolecular Nutrition & Food Research, 2015, vol. 59, núm. 7, p. 1395–1399ca_ES
dc.rights(c) Wiley-VCH Verlag, 2015ca_ES
dc.subjectBiodistributionca_ES
dc.subjectDose-uptakeca_ES
dc.subjectHydroxytyrosolca_ES
dc.subjectPhenol metabolitesca_ES
dc.subjectTissue dispositionca_ES
dc.titleDose effect on the uptake and accumulation of hydroxytyrosol and its metabolites in target tissues in ratsca_ES
dc.typearticleca_ES
dc.identifier.idgrec022585
dc.type.versionacceptedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/mnfr.201500048


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