Now showing items 1-20 of 57

    • 7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome 

      Gou Fàbregas, Myriam; Macià Armengol, Anna; Anerillas, Carlos; Vaquero, Marta; Jové Font, Mariona; Jain, Sanjay; Ribera i Calvet, Joan; Encinas Martín, Mario (Nature Publishing Group, 2016)
      Smith-Lemli-Opitz syndrome (SLOS) is a rare disorder of cholesterol synthesis. Affected individuals exhibit growth failure, intellectual disability and a broad spectrum of developmental malformations. Among them, renal ...
    • Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy 

      Morató, Laia; Ruiz, M.; Boada Pallàs, Jordi; Calingasan, Noel Ylagan; Galino, Jorge; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Serrano, M.; Portero Otín, Manuel; Beal, M. F.; Fourcade, Stéphane; Pujol, Aurora (Macmillan Publishers, 2015)
      Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the ...
    • Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy 

      Ruiz, Montserrat; Jové Font, Mariona; Schlüter, Agatha; Casasnovas, Carlos; Villarroya, Francesc; Guilera, Cristina; Ortega, Francisco J.; Naudí i Farré, Alba; Pamplona Gras, Reinald; Gimeno, Ramón; Fourcade, Stéphane; Portero Otín, Manuel; Pujol, Aurora (Oxford University Press, 2015)
      X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ...
    • Biofortification of crops with nutrients: factors affecting utilization and storage 

      Díaz Gómez, Joana; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
      Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
    • Biomarkers of aging in Drosophila 

      Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
      Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
    • Calcium channel expression and applicability as targeted therapies in melanoma 

      Macià Armengol, Anna; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Cantí Nicolás, Carles (Hindawi Publishing Corporation, 2015)
      The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ...
    • Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice 

      Jové Font, Mariona; Naudí i Farré, Alba; Ramírez-Núñez, Omar; Portero Otín, Manuel; Selman, Colin; Withers, Dominic J.; Pamplona Gras, Reinald (John Wiley & SonsAnatomical Society, 2014-10-01)
      Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects ...
    • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

      Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2014)
      Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
    • Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis 

      Nogareda, Carmina; Moreno, José A.; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (John Wiley & SonsWiley-Blackwell, 2015)
      Carotenoids are health-promoting organic molecules that act as antioxidants and essential nutrients. We show that chickens raised on a diet enriched with an engineered corn variety containing very high levels of four key ...
    • Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Gonzalo Benito, Hugo; Boada Pallàs, Jordi; Prat Corominas, Joan; Portero Otín, Manuel; Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2012)
      Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron ...
    • Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Camats, Judith; David, Mónica Delia; Benguria, Alberto; Dopazo, Ana; Cantí Nicolás, Carles; Herreros Danés, Judit (Frontiers, 2013)
      Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that ...
    • Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease 

      Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2010)
      Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ...
    • Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner 

      Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Granado-Serrano, Ana Belén; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Cabré Cucó, Rosanna; Nadal Rey, Gisela; Bellmunt i Curcó, Josepa; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Springer, 2014)
      The implication of lipid peroxidation in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) derive from high abundance of peroxidation- prone polyunsaturated fatty acids in central nervous system ...
    • Do primary health centres and hospitals contribute equally towards achievement of the transversal clinical competencies of medical students? Performance on the Objective Structured Clinical Examination (OSCE) in competency acquisition 

      Soler González, Jorge; Buti, Miquel; Boada Pallàs, Jordi; Ayala Jové, Ma. Victoria (Maria Victoria); Peñascal Pujol, Eduard; Rodriguez, Toni (Elsevier España, 2016)
      Objectives: The adaptation of the educational programmes of European faculties of medicine to the European Higher Education Area guidelines has focused curricula design on competence acquisition. Competencies are defined ...
    • Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS 

      Cacabelos Barral, Daniel; Ramírez-Núñez, Omar; Granado-Serrano, Ana Belén; Torres, Pascual; Ayala Jové, Ma. Victoria (Maria Victoria); Moiseeva, Victoria; Povedano, Mònica; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi (BioMed Central, 2016)
      Introduction: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with a gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunction ...
    • Effect of dietary bioactive compounds on mitochondrial and metabolic flexibility 

      Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Martín-Gari, Meritxell; Granado-Serrano, Ana Belén; Portero Otín, Manuel (MDPI, 2016-03)
      Metabolic flexibility is the capacity of an organism to adequately respond to changes in the environment, such as nutritional input, energetic demand, etc. An important player in the capacity of adaptation through different ...
    • Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA 

      Betriu i Bars, M. Àngels; Farràs, Cristina; Abajo, María; Martínez Alonso, Montserrat; Arroyo, David; Barbé Illa, Ferran; Buti, Miquel; Lecube Torelló, Albert; Portero Otín, Manuel; Purroy Garcia, Francisco; Torres, Gerard; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología, 2016)
      Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer ...
    • Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction 

      Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Caro, Pilar; Gomez, José; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Springer Verlag, 2013)
      Maillard reaction contributes to the chemical modification and cross-linking of proteins. This process plays a significant role in the aging process and determination of animal longevity. Oxidative conditions promote the ...
    • Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer 

      Granados Principal, Sergio; El-azem, Nuri; Pamplona Gras, Reinald; Ramirez Tortosa, Cesar; Pulido Moran, Mario; Vera Ramirez, Laura; Quiles, Jose L.; Sánchez Rovira, Pedro; Naudí i Farré, Alba; Portero Otín, Manuel; Pérez López, Patricia; Ramírez Tortosa, MCarmen (Elsevier, 2014)
      Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant ...
    • Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy 

      López Erauskin, Jone; Galino, Jorge; Ruiz, M.; Cuezva, J. M.; Fabregat, I.; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Martínez, Juan José; Ferrer, Isidre; Pamplona Gras, Reinald; Villarroya, Francesc; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, A. (Oxford Journals, 2013)
      X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ...