Now showing items 1-2 of 2

    • 2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53 

      Mattiolo, Paolo; Barbero-Farran A.; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2014)
      2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ...
    • Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment 

      Ribas i Fortuny, Judit; Mattiolo, Paolo; Boix Torras, Jacint (Bentham Science, 2015-01-01)
      Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer ...