Browsing Articles publicats (Grup de Recerca en Neurobiologia Cel·lular) by Subject "PES (2-phenylethynesulfonamide)"
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2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
(Elsevier, 2014)2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ... -
Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX
(Elsevier, 2014)PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ... -
Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment
(Bentham Science, 2015-01-01)Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer ...