Now showing items 1-4 of 4

    • 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death 

      Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José); Garrofé Ochoa, Xènia; Meijer, Laurent; Esquerda Colell, Josep; Boix Torras, Jacint (Elsevier, 2008)
      The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ...
    • BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis 

      Garrofé Ochoa, Xènia; Melero Fernández de Mera, Raquel M; Fernández Gómez, Francisco J.; Ribas i Fortuny, Judit; Jordán Bueso, Joaquín; Boix Torras, Jacint (American Association for Cancer Research, 2008)
      In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ...
    • Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX 

      Mattiolo, Paolo; Barbero-Farran A.; Amigó J.; Ripamonti M.; Ribas i Fortuny, Judit; Boix Torras, Jacint (Elsevier, 2014)
      PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ...
    • Trancriptional modulation of apoptotis regulators by Roscovitine and related compounds 

      Garrofé Ochoa, Xènia; Cosialls, Ana M; Ribas i Fortuny, Judit; Gil, Joan; Boix Torras, Jacint (Springer Science Business Media, 2011)
      Chemical inhibitors of cyclin-dependent kinase (CDK), like roscovitine, are promising drugs in thecontext of new cancer therapies. Roscovitine and related compounds, like seliciclib and olomoucine, are effective inducers ...