Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination
De Piccoli, Giacomo
Cortes Ledesma, Felipe
Cordon Preciado, Violeta
Clemente Blanco, Andrés
Vilella Mitjana, Felipe
Haber, James E.
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DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5–Smc6 complex is recruited to DSBs de novo to support their repair by homologous
recombination between sister chromatids. In addition, we demonstrate that Smc5–Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5–Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sisterchromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.
Is part ofNature Cell Biology, 2006, vol. 8, núm. 9, p. 1032-1034
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