Hydroxytyrosol and its complex forms (secoiridoids) modulate aorta and heart proteome in healthy rats: Potential cardio-protective effects
Catalán Santos, Úrsula
MetadataShow full item record
Scope Hydroxytyrosol (HT) is the major phenolic compound in virgin olive oil (VOO) in both free and complex forms (secoiridoids; SEC). Proteomics of cardiovascular tissues such as aorta or heart represents a promising tool to uncover the mechanisms of action of phenolic compounds in healthy animals.
Is part ofMolecular Nutrition & Food Research, 2016, vol. 60, núm. 10, p. 2114–2129
European research projects
Showing items related by title, author, creator and subject.
Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells Catalán Santos, Úrsula; López de las Hazas Mingo, María del Carmen; Rubió Piqué, Laura; Fernández Castillejo, Sara; Pedret, Anna; De la Torre, Rafael; Motilva Casado, Mª José; Solà, Rosa (Wiley, 2015)Scope Hydroxytyrosol (HT) is the major phenolic compound in virgin olive oil (VOO) in free and conjugated forms that may exert health benefits against atherosclerosis. The native form of HT is undetectable in plasma due ...
Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study) Pedret, Anna; Catalán Santos, Úrsula; Fernandez-Castillejo, Sara; Farràs, Marta; Valls, Rosa M.; Rubió Piqué, Laura; Canela, Núria; Aragonés, Gerard; Romeu, Marta; Castaner, Olga; De la Torre, Rafael; Covas Planells, María Isabel; Fitó, Montserrat; Motilva Casado, Mª José; Solà, Rosa (Public Library Science, 2015-06-10)The effects of olive oil phenolic compounds (PCs) on HDL proteome, with respect to new aspects of cardioprotective properties, are still unknown. The aim of this study was to assess the impact on the HDL protein cargo of ...
Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway Catalán Santos, Úrsula; López de las Hazas Mingo, María del Carmen; Piñol Felis, Carme; Rubió Piqué, Laura; Motilva Casado, Mª José; Fernández Castillejo, Sara; Solà, Rosa (Elsevier, 2018-01)The main aim of this work is to gain insight into the potential mechanisms of hydroxytyrosol (HT) and its mainplasmatic metabolites (HTmet) that improve the endothelial function. Feeding ApoE−/−mice with 10 mg/kg/day of ...