Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial
Issue date
2017Author
Valls, Rosa M.
Farràs, Marta
Pedret, Anna
Fernández Castillejo, Sara
Catalán Santos, Úrsula
Romeu, Marta
Giralt, Montserrat
Sáez, Guillermo T.
Fitó, Montserrat
De la Torre, Rafael
Covas Planells, María Isabel
Solà, Rosa
Suggested citation
Valls, Rosa M.;
Farràs, Marta;
Pedret, Anna;
Fernández Castillejo, Sara;
Catalán Santos, Úrsula;
Romeu, Marta;
...
Rubió Piqué, Laura.
(2017)
.
Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial.
Journal of Functional Foods, 2017, vol. 28, p. 285–292.
https://doi.org/10.1016/j.jff.2016.10.032.
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Show full item recordAbstract
The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the endothelial function. In order to select the optimal phenolic dose in the improvement of ischemic reactive hyperemia (IRH), a dose-response study (n = 12, healthy subjects) was performed and the enrichment of 500 mg PC/kg oil was selected. In a 3-week cross-over sustained study (n = 33 hypercholesterolemic subjects), the consumption of 25 mL/day of two phenol-enriched olive oils (one enriched with its own PC and another combined with thyme PC) increased IRH and plasma concentrations of retinol, β-cryptoxanthin and α-tocopherol, compared to a control virgin olive oil. A positive post-intervention correlation was observed for IRH values and HDL-c, β-cryptoxanthin, lutein and α-tocopherol. Results suggest that preservation of plasmatic fat-soluble vitamins by PC from FVOOS could partially explain the endothelial function benefits.
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Journal of Functional Foods, 2017, vol. 28, p. 285–292European research projects
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