Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial
Data de publicació2017
Valls, Rosa M.
Fernández Castillejo, Sara
Catalán Santos, Úrsula
Sáez, Guillermo T.
De la Torre, Rafael
Covas Planells, María Isabel
MetadadesMostra el registre d'unitat complet
The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the endothelial function. In order to select the optimal phenolic dose in the improvement of ischemic reactive hyperemia (IRH), a dose-response study (n = 12, healthy subjects) was performed and the enrichment of 500 mg PC/kg oil was selected. In a 3-week cross-over sustained study (n = 33 hypercholesterolemic subjects), the consumption of 25 mL/day of two phenol-enriched olive oils (one enriched with its own PC and another combined with thyme PC) increased IRH and plasma concentrations of retinol, β-cryptoxanthin and α-tocopherol, compared to a control virgin olive oil. A positive post-intervention correlation was observed for IRH values and HDL-c, β-cryptoxanthin, lutein and α-tocopherol. Results suggest that preservation of plasmatic fat-soluble vitamins by PC from FVOOS could partially explain the endothelial function benefits.
És part deJournal of Functional Foods, 2017, vol. 28, p. 285–292
Projectes de recerca europeus
Mostrant elements relacionats per títol, autor i matèria.
Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study) Pedret, Anna; Catalan, Ursula; Fernandez-Castillejo, Sara; Farràs, Marta; Valls, Rosa M.; Rubió Piqué, Laura; Canela, Núria; Aragonés, Gerard; Romeu, Marta; Castaner, Olga; De la Torre, Rafael; Covas Planells, María Isabel; Fitó, Montserrat; Motilva Casado, Mª José; Solà, Rosa (Public Library Science, 2015-06-10)The effects of olive oil phenolic compounds (PCs) on HDL proteome, with respect to new aspects of cardioprotective properties, are still unknown. The aim of this study was to assess the impact on the HDL protein cargo of ...
A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial Farràs, Marta; Arranz, Sara; Carrión Bolorino, Silvia; Subirana Cachinero, Isaac; Muñoz-Aguayo, Daniel; Blanchart, Gemma; Kool, Marjon; Solà, Rosa; Motilva Casado, Mª José; Escolà Gil, Joan Carles; Rubió Piqué, Laura; Fernández Castillejo, Sara; Pedret, Anna; Estruch Riba, Ramon; Covas Planells, María Isabel; Fitó, Montserrat; Hernáez Camba, Álvaro; Castañer, Olga (MDPI, 2019)The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) ...
Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A Randomized Controlled Trial Valls, Rosa M.; Farràs, Marta; Suárez, Manuel; Fernández Castillejo, Sara; Fitó, Montserrat; Konstantinidou, Valentini; Fuentes, Francisco; López-Miranda, José; Giralt, Montserrat; Covas Planells, María Isabel; Motilva Casado, Mª José; Solà, Rosa (Elsevier, 2015)The additional health-promoting properties of functional virgin olive oil (FVOO) enriched with its own phenolic compounds (OOPC) versus the parental virgin olive oil (VOO) must be tested in appropriate human clinical ...