Universitat de Lleida
    • English
    • català
    • español
  • English 
    • English
    • català
    • español
  • Login
Repositori Obert UdL
View Item 
  •   Home
  • Recerca
  • Ciències Mèdiques Bàsiques
  • Articles publicats (Ciències Mèdiques Bàsiques)
  • View Item
  •   Home
  • Recerca
  • Ciències Mèdiques Bàsiques
  • Articles publicats (Ciències Mèdiques Bàsiques)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility

Thumbnail
View/Open
016534.pdf (1.026Mb)
Sol·licita una còpia
Issue date
2011
Author
Fernández, Rosa M. H.
Ruiz Miró, Maria
Dolcet Roca, Xavier
Aldea, Martí
Garí Marsol, Eloi
Suggested citation
Fernández, Rosa M. H.; Ruiz Miró, Maria; Dolcet Roca, Xavier; Aldea, Martí; Garí Marsol, Eloi; . (2011) . Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility. Oncogene, 2011, vol. 30, p. 1936-1946. https://doi.org/10.1038/onc.2010.577.
Impact


Web of Science logo    citations in Web of Science

Scopus logo    citations in Scopus

Google Scholar logo  Google Scholar
Share
Export to Mendeley
Metadata
Show full item record
Abstract
Alterations in the levels of adhesion and motility of cells are critical events in the development of metastasis. Cyclin D1 (CycD1) is one of the most frequently amplified oncogenes in many types of cancers and it is also associated with the development of metastasis. Despite this, we still do not know which are all the relevant pathways by which CycD1 induces oncogenic processes. CycD1 functions can be either dependent or independent of the cyclin-dependent kinase Cdk4, and they affect several cellular aspects such as proliferation, cell attachment and migration. In this work, we reveal a novel function of CycD1 that fosters our understanding of the oncogenic potential of CycD1. We show that CycD1 binds to the small GTPases Ral A and B, which are involved, through exocyst regulation, in the progression of metastatic cancers, inducing anchorage-independent growth and cell survival of transformed cells. We show that CycD1 binds active Ral complexes and the exocyst protein Sec6, and co-localizes with Ral GTPases in trans-Golgi and exocyst-rich regions. We have also observed that CycD1–Cdk4 phosphorylates the Ral GEF Rgl2 ‘in vitro’ and that CycD1–Cdk4 activity stimulates accumulation of the Ral GTP active forms. In accordance with this, our data suggest that CycD1–Cdk4 enhances cell detachment and motility in collaboration with Ral GTPases. This new function may help explain the contribution of CycD1 to tumor spreading.
URI
http://hdl.handle.net/10459.1/59092
DOI
https://doi.org/10.1038/onc.2010.577
Is part of
Oncogene, 2011, vol. 30, p. 1936-1946
European research projects
Collections
  • Articles publicats (IRBLleida) [1161]
  • Publicacions de projectes de recerca del Plan Nacional [2948]
  • Articles publicats (Ciències Mèdiques Bàsiques) [580]

Contact Us | Send Feedback | Legal Notice
© 2023 BiD. Universitat de Lleida
Metadata subjected to 
 

 

Browse

All of the repositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

Statistics

View Usage Statistics

D'interès

Política institucional d'accés obertDiposita les teves publicacionsDiposita dades de recercaSuport a la recerca

Contact Us | Send Feedback | Legal Notice
© 2023 BiD. Universitat de Lleida
Metadata subjected to