Show simple item record

dc.contributor.authorPurroy Garcia, Francisco
dc.contributor.authorCambray Carner, Serafí
dc.contributor.authorMauri-Capdevila, Gerard
dc.contributor.authorJové Font, Mariona
dc.contributor.authorSanahuja Montesinos, Jordi
dc.contributor.authorFarré, Joan
dc.contributor.authorBenabdelhak Abbou, Ikram
dc.contributor.authorMolina Seguin, Jessica
dc.contributor.authorColàs Campàs, Laura
dc.contributor.authorBegué Gómez, Robert
dc.contributor.authorGil, M. Isabel
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorPortero Otín, Manuel
dc.date.accessioned2017-01-24T11:48:31Z
dc.date.available2017-01-24T11:48:31Z
dc.date.issued2016
dc.identifier.issn2352-3964
dc.identifier.urihttp://hdl.handle.net/10459.1/59086
dc.description.abstractBackground: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite its relevance, magnetic resonance diffusionweighted imaging (DWI) is not always available in all hospitals that attend to TIA patients. Methods: Metabolomic analyses were performed by liquid chromatography coupled to mass spectrometry in order to establish the metabolomic patterns of positive DWI, DWI patterns and acute ischemic lesion volumes. We used these methods with an initial TIA cohort of 129 patients and validated them with a 2nd independent cohort of 152 patients. Findings: PositiveDWIwas observed in 115 (40.9%) subjects and scattered pearls in one arterial territory was the most frequent lesion pattern (35.7%). The median acute ischemic lesion volume was 0.33 (0.15–1.90) cm3. We detected a specific metabolomic profile common to both cohorts for positive DWI (11 molecules including creatinine, threoninyl-threonine, N-acetyl-glucosamine, lyso phosphatidic acid and cholesterol-related molecules) and ischemic lesion volume (10 molecules including lysophosphatidylcholine, hypoxanthine/threonate, and leucines). Moreover lysophospholipids and creatinine clearly differed the subcortical DWI pattern from other patterns. Interpretation: There are specific metabolomic profiles associated with representative neuroimaging features in TIA patients. Our findings could allow the development of serum biomarkers related to acute ischemic lesions and specific acute ischemic patterns.ca_ES
dc.description.sponsorshipThis work has been supported by the Government of Catalonia-Agència de Gestió d'Ajuts Universitaris i de Recerca [2009SGR-735 and 2014SGR-1418], the Spanish Ministry of Health [FIS 11-02033, 14-001115 and 14-00328] and the Marató of TV3 Foundation [95/C/2011]. It was also supported by the European Regional Development Fund (PI 14/01115) “A way to build Europe”.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.ebiom.2016.11.010ca_ES
dc.relation.ispartofEBioMedicine, 2016, vol. 14, p. 131–138ca_ES
dc.rightscc-by-nc-nd (c) Purroy et al., 2016ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDiffusion magnetic resonance imagingca_ES
dc.subjectMetabolomicsca_ES
dc.subjectTIAca_ES
dc.titleMetabolomics predicts neuroimaging characteristics of transient ischemic attack patientsca_ES
dc.typearticleca_ES
dc.identifier.idgrec024916
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.ebiom.2016.11.010


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

cc-by-nc-nd (c) Purroy et al., 2016
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Purroy et al., 2016