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dc.contributor.authorCabré Cucó, Rosanna
dc.contributor.authorJové Font, Mariona
dc.contributor.authorNaudí i Farré, Alba
dc.contributor.authorAyala Jové, Ma. Victoria (Maria Victoria)
dc.contributor.authorPiñol Ripoll, Gerard
dc.contributor.authorGil Villar, M. Pilar
dc.contributor.authorDominguez Gonzalez, Mayelin
dc.contributor.authorObis Monné, Èlia
dc.contributor.authorBerdún Hernández, Rebeca
dc.contributor.authorMota Martorell, Natàlia
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorFerrer, Isidre
dc.contributor.authorPamplona Gras, Reinald
dc.description.abstractBrain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed to the great diversity among neuronal populations. Here we have determined the metabolomic profile of three healthy adult human brain regions—entorhinal cortex, hippocampus, and frontal cortex—using mass spectrometry-based technologies. Our results show the existence of a lessened energy demand, mitochondrial stress, and lower one-carbon metabolism (particularly restricted to the methionine cycle) specifically in frontal cortex. These findings, along with the better antioxidant capacity and lower mTOR signaling also seen in frontal cortex, suggest that this brain region is especially resistant to stress compared to the entorhinal cortex and hippocampus, which are more vulnerable regions. Globally, our results show the presence of specific metabolomics adaptations in three mature, healthy human brain regions, confirming the existence of cross-regional differences in cell vulnerability in the human cerebral cortex.ca_ES
dc.description.sponsorshipThis research was funded by the Spanish Ministry of Economy and Competitiveness, Institute Carlos III (FIS grants PI14/00757 and PI14/00328), and the Autonomous Government of Catalonia (2014SGR69 and 2014SGR168) to IF and RP. This study was co-financed by FEDER funds from the European Union (‘A way to build Europe’). RC received predoctoral fellowships from the Autonomous Government of Catalonia. We thank T. Yohannan for editorial help.ca_ES
dc.publisherFrontiers in Molecular Neurosciencieca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofFrontiers in Molecular Neuroscience, 2016, vol. 9, núm. 138, p. 1-13ca_ES
dc.rightscc-by (c) Cabré Cucó, Rosanna., et al. 2016ca_ES
dc.subjectEnergy metabolism,ca_ES
dc.subjectMammalian target of rapamycin (mTOR)ca_ES
dc.subjectMethionine cycleca_ES
dc.subjectMitochondrial stressca_ES
dc.subjectNucleotide metabolismca_ES
dc.subjectOne-carbon metabolismca_ES
dc.subjectSelective neuronal vulnerabilityca_ES
dc.titleSpecific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortexca_ES

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cc-by (c) Cabré Cucó, Rosanna., et al. 2016
Except where otherwise noted, this item's license is described as cc-by (c) Cabré Cucó, Rosanna., et al. 2016