Show simple item record

dc.contributor.authorDávila, José Carlos
dc.contributor.authorReal, M. Ángeles
dc.contributor.authorOlmos, Luis
dc.contributor.authorLegaz, Isabel
dc.contributor.authorMedina Hernández, Loreta Mª
dc.contributor.authorGuirado, Salvador
dc.date.accessioned2017-01-20T10:15:10Z
dc.date.issued2005
dc.identifier.issn0021-9967
dc.identifier.urihttp://hdl.handle.net/10459.1/59055
dc.description.abstractWe analyzed the development of immunoreactive expression patterns for the neurotransmitter -aminobutyric acid (GABA) and the calcium-binding proteins calbindin, calretinin, and parvalbumin in the embryonic and postnatal mouse claustral complex. Each calcium-binding protein shows a different temporal and spatial pattern of development. Calbindin-positive cells start to be seen very early during embryogenesis and increase dramatically until birth, thus becoming the most abundant cell type during embryonic development, especially in the ventral pallial part of the claustrum. The distribution of calbindin neurons throughout the claustrum during embryonic development partly parallels that of GABA neurons, suggesting that at least part of the calbindin neurons of the claustral complex are GABAergic and originate in the subpallium. Parvalbumin cells, on the other hand, start to be seen only postnatally, and their number then increases while the density of calbindin neurons decreases. Based on calretinin expression in axons, the core/shell compartments of the dorsal claustrum start to be clearly seen at embryonic day 18.5 and may be related to the development of the thalamoclaustral input. Comparison with the expression of Cadherin 8, a marker of the developing dorsolateral claustrum, indicates that the core includes a central part of the dorsolateral claustrum, whereas the shell includes a peripheral area of the dorsolateral claustrum, plus the adjacent ventromedial claustrum. The present data on the spatiotemporal developmental patterns of several subtypes of GABAergic neurons in the claustral complex may help for future studies on temporal lobe epilepsies, which have been related to an alteration of the GABAergic activity.ca_ES
dc.description.sponsorshipGrant sponsor: Spanish Direccio´n General de Investigacio´n-Fondo Europeo de Desarrollo Regional (FEDER); Grant number: BFI2003-06453-C02-01/02; Grant sponsor: Fondo de Investigaciones Sanitarias-FEDER; Grant number: 01/0057-02; Grant sponsor: Se´neca; Grant number: PB/50/FS/02; Grant sponsor: Red Centro de Investigacio´n de Enfermedades Neurolo´gicas-Nodo 318.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICYT/PN2000-2003/BFI2003-06453-C02-01/02
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/cne.20347ca_ES
dc.relation.ispartofThe Journal of Comparative Neurology, 2005, vol. 481, núm. 1, p. 42–57ca_ES
dc.rights(c) Wiley-Liss, Inc. 2005ca_ES
dc.subjectCalcium-binding proteinsca_ES
dc.subjectDorsal claustrumca_ES
dc.subjectEndopiriform nucleusca_ES
dc.subjectImmunohistochemistryca_ES
dc.titleEmbryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complexca_ES
dc.typearticleca_ES
dc.identifier.idgrec011374
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/cne.20347
dc.date.embargoEndDate10000-01-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record