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dc.contributor.authorMedina Hernández, Loreta Mª
dc.contributor.authorAbellán Ródenas, Antonio
dc.date.accessioned2017-01-19T11:28:19Z
dc.date.issued2009
dc.identifier.issn1084-9521
dc.identifier.urihttp://hdl.handle.net/10459.1/59040
dc.description.abstractThe neocortex is the most representative and elaborated structure of the mammalian brain and is related to the achievement of complex cognitive capabilities, which are disturbed following malformation or lesion. Searching for the evolutionary origin of this structure continues to be one of the most important and challenging questions incomparative neurobiology.However, this is extremely difficult because of the highly divergent evolution of the pallium in different vertebrates, which has obscured the comparison. Herein, we review developmental neurobiology data for trying to understand the genetic factors that define and underlie the parcellation of homologous pallial subdivisions in different vertebrates. According to these data, the pallium in all tetrapods parcellates during development into four major histogenetic subdivisions, whichare homologous as fields across species. The neocortex derives fromthe dorsal pallium and, as such, is only comparable to the sauropsidian dorsal pallium (avian hyperpallium and lizard/turtle dorsal cortex).We also tried to identify developmental changes in phylogeny that may be responsible of pallial divergent evolution. In particular, we point out to evolutionary differences regarding the cortical hem (an important signaling center for pallial patterning, that also is a source of Cajal–Retzius cells, which are involved in cortical lamination), whichmay be behind the distinct organization of the pallium in mammals and non-mammals. In addition, we mention recent data suggesting a correlation between the appearance and elaboration of the subventricular zone (a newgerminative cell layer of the developing neocortex), and the evolution of novel cell layers (the supragranular layers) and interneuron subtypes. Finally,we comment on epigenetic factors that modulate the developmental programs, leading to changes in the formation of functional areas in the pallium (within some constraints).ca_ES
dc.description.sponsorshipThis work was supported by grants to L.M. from the Spanish Ministry of Education and Science and FEDER (DGICYT-FEDER: BFU2006-14804-C02-02/BFI).ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMIECI/PN2004-2007/BFU2006-14804-C02-02/BFI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.semcdb.2009.04.008ca_ES
dc.relation.ispartofSeminars in Cell & Developmental Biology, 2009, vol. 20, núm. 6, p. 698–711ca_ES
dc.rights(c) Elsevier Ltd. 2009ca_ES
dc.subjectPatterningca_ES
dc.subjectParcellationca_ES
dc.subjectGenetic regulationca_ES
dc.subjectTranscription factorsca_ES
dc.titleDevelopment and evolution of the palliumca_ES
dc.typearticleca_ES
dc.identifier.idgrec013519
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.semcdb.2009.04.008
dc.date.embargoEndDate2025-01-01


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