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dc.contributor.authorAbellán Ródenas, Antonio
dc.contributor.authorMedina Hernández, Loreta Mª
dc.date.accessioned2017-01-19T11:16:29Z
dc.date.issued2009
dc.identifier.issn0021-9967
dc.identifier.urihttp://hdl.handle.net/10459.1/59039
dc.description.abstractHere we studied the combinatory expression patterns of nine developmental regulatory genes and six markers of different neuronal subpopulations in the telencephalic subpallium of developing chicken, from early embryos until hatching, in order to better understand the formation and organization of the basal telencephalon and the origin of its different cell groups. The genes analyzed include those encoding for: the transcription factors Islet1, Lhx6, Lhx7/8, Nkx2.1, and Pax6; the signaling protein Sonic hedgehog; the LIM-only genes Lmo3 and Lmo4; the cell adhesion molecule cadherin-8; markers of -aminobutyric acid (GABA)ergic, cholinergic, or glutamatergic neurons; and markers of neuron subpopulations containing substance P, enkephalin, or neuropeptide Y. The combinatory expression patterns of these genes indicate that the chicken subpallium parcellates into eight molecularly different compartments during development (three striatal, three pallidal, and two preoptic subdivisions), and suggest that each compartment produces specific cell groups. Our data are particularly relevant for understanding the avian extended amygdala and suggest the existence of distinct central and medial extended amygdala complexes in the subpallium, as well as a pallial amygdalo-hypothalamic cell corridor, which are comparable to homonymous complexes of mammals based on similar embryonic origin, molecular features, and some connectivity patterns. Our data also indicate that the dorsal and ventral parts of the chicken basal ganglia originate in different striatal and pallidal compartments, and suggest a massive migration of neurons from the pallidal compartment into the medial striatum, which may explain the existence of pallidal-like cells within the medial striatum of birds. J. Comp. Neurol. 515:465–501, 2009.ca_ES
dc.description.sponsorshipGrant sponsor: the Spanish Ministry of Education and Science—Fondo Europeo de Desarrollo Regional (FEDER); Grant numbers: BFI2003-06453- C02-02 and BFU2006-14804-C02-02/BFI (to L.M.). Predoctoral fellowship to A.A.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICYT/PN2000-2003/BFI2003-06453- C02-02
dc.relationMIECI/PN2004-2007/BFU2006-14804-C02-02/BFI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/cne.22083ca_ES
dc.relation.ispartofThe Journal of Comparative Neurology, 2009, vol. 515, núm. 4, p. 465–501ca_ES
dc.rights(c) Wiley-Liss, Inc. 2009ca_ES
dc.subjectcLhx6ca_ES
dc.subjectcLhx7/8ca_ES
dc.subjectcLmo3ca_ES
dc.subjectcLmo4ca_ES
dc.subjectIslet1ca_ES
dc.subjectcPax6ca_ES
dc.subjectGABAca_ES
dc.titleSubdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during developmentca_ES
dc.typearticleca_ES
dc.identifier.idgrec013518
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/cne.22083
dc.date.embargoEndDate2025-01-01


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