Genetic and experimental evidence supports the continuum of the central extended amygdala and a mutiple embryonic origin of its principal neurons
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Date
2011
Authors
Bupesh, Munisamy
Abellán Ródenas, Antonio
Medina Hernández, Loreta Mª
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Abstract
The central extended amygdala is the major output
center for telencephalic control of ingestion, fear
responses, stress, and anxiety. In spite of the abundant
data supporting the similarity in neurochemistry, connections,
and function along the extended amygdala,
embryological support for this continuum is lacking. By
using a combination of in vitro migration assays, in situ
hybridization, and immunostaining, here we show that
its major components, including central amygdala and
lateral bed nucleus of the stria terminalis (BST), are
mosaics formed by different proportions of dorsal lateral
ganglionic eminence (LGE)-, ventral LGE-, and
medial ganglionic eminence (MGE)-derived principal
neurons. The dorsal LGE produces Pax6-expressing neurons
that primarily populate lateral parts of the central
extended amygdala, including the capsular and part of
lateral central amygdala, but also produces a few cells
for the lateral BST. Based on correlation with preproenkephalin,
many of these cells are likely enkephalinergic.
The ventral LGE produces Islet1-expressing neurons
that populate primarily the central and medial parts of
the central amygdala but also produces numerous neurons
for the lateral BST. Correlation with corticotropinreleasing
factor suggests that these neurons express
this neuropeptide. The MGE produces the majority of
neurons of the lateral BST, but its ventrocaudal subdivision
also produces an important subpopulation of projection
neurons containing somatostatin for medial
aspects of the central amygdala. Thus, distinct principal
neurons originate in different embryonic domains, but
the same domains contribute neurons to most subdivisions
of the central extended amygdala, which may
explain the similarity in neurochemistry and connections
along the corridor.
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The Journal of Comparative, 2011, vol. 519, núm. 17, p. 3507-3531